Academic Press Inc

This highly engaging guide for clinical researchers provides a foundation for improving skills in the understanding of ethical requirements in the design and conduct of clinical research. It includes practical information on ethical principles in clinical research, designing appropriate research studies, writing consent and assent documents, getting protocols approved, special populations, confidentiality issues, and the reporting of adverse events. A valuable appendix includes a listing of web resources about research ethics as well as a glossary. This will be an invaluable resource for basic scientists collaborating in clinical trials, physician investigators, clinical research fellows, research nurse coordinators, residents, and anyone who wants a better understanding of the clinical trials process. It walks investigators and trainees through identification of the ethical aspects of each section of a clinical research protocol. It includes a chapter containing Case Histories. It contains information on conducting clinical research within the pharmaceutical industry. An appendix includes internet resources and world wide web addresses for important research ethics documents and regulations. Chapter on 'Study Design and Methodology' purposely expanded to explicitly address biostatistical considerations.

Most of the diseases of modern mankind involve either acute or chronic inflammation. "Measuring Immunity" integrates the current information available on biomarkers and surrogate assays into a single handbook. It highlights the principles behind various applications, gives a brief summary on how they are conducted and provides detailed and critical analyses of murine models of immunity, clinical trials, and tests to predict utility and benefit. "Measuring Immunity" is indispensable for scientists and clinicians interested in the clinical applications of modern immunobiology. It defines which assays of immune function are helpful in the assessment of clinical disorders involving inflammation and immunity. It assesses the dynamics of cellular and soluble factors in the peripheral blood using modern techniques. It includes basic science foundations as well as the approaches currently applied.

PET and SPECT are two of todays most important medical-imaging methods, providing images that reveal subtle information about physiological processes in humans and animals. "Emission Tomography: The Fundamentals of PET and SPECT" explains the physics and engineering principles of these important functional-imaging methods. The technology of emission tomography is covered in detail, including historical origins, scientific and mathematical foundations, imaging systems and their components, image reconstruction and analysis, simulation techniques, and clinical and laboratory applications. The book describes the state of the art of emission tomography, including all facets of conventional SPECT and PET, as well as contemporary topics, such as iterative image reconstruction, small-animal imaging, and PET/CT systems. This book is intended as a textbook and reference resource for graduate students, researchers, medical physicists, biomedical engineers, and professional engineers and physicists in the medical-imaging industry. Thorough tutorials of fundamental and advanced topics are presented by dozens of the leading researchers in PET and SPECT. SPECT has long been a mainstay of clinical imaging, and PET is now one of the worlds fastest growing medical imaging techniques, owing to its dramatic contributions to cancer imaging and other applications. "Emission Tomography: The Fundamentals of PET and SPECT" is an essential resource for understanding the technology of SPECT and PET, the most widely used forms of molecular imaging. The features are: contains thorough tutorial treatments, coupled with coverage of advanced topics; three of the four holders of the prestigious Institute of Electrical and Electronics Engineers Medical Imaging Scientist Award are chapter contributors; and includes color artwork.

This second edition of a very successful text reflects the tremendous pace of human genetics research and the demands that it places on society to understand and absorb its basic implications. The human genome has now been officially mapped and the cloning of animals is becoming a commonplace scientific discussion on the evening news. Join authors Julia Richards and Scott Hawley as they examine the biological foundations of humanity, looking at the science behind the sensation and the current and potential impact of the study of the genome on our society. The "Human Genome, Second Edition" is ideal for students and non-professionals, but will also serve as a fitting guide for the novice geneticist by providing a scientific, humanistic, and ethical frame of reference for a more detailed study of genetics. This edition has 60 per cent new material, including data from the Human Genome Project and the latest genetics and ethics discussions. Several new case studies and personal stories bring the concepts of genetics and heredity to life. There is simplified treatment of material for non-biology majors. There is new full-color art throughout the text. New co-author, Julia Richards, joins R. Scott Hawley in this revision.

The various cell types have traditionally been recognized and classified according to their appearance in the light microscope following the process of fixing, processing, sectioning, and staining tissues that is known as histology. Classical histology has been augmented by immunohistochemistry (the use of specific antibodies to stain particular molecular species in situ). Immunohistochemistry has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system. This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today, ensuring a wide audience for this book. This is the only book available that translates molecular genetics into cancer diagnosis. It provides the readers with tools necessary to perform and optimize sensitive, powerful techniques, including immunohistochemistry and fluorescence in situ hybridization, used in tumor diagnosis. Written by experts in this field, the book provides theoretical considerations as well as practical approaches to carry out effectively these techniques. It offers suggestions, tips, cautions, and guidelines to avoid artifacts and misdiagnosis. It introduces new techniques to detect genes and proteins involved in the initiation and progression of cancer. It covers the latest developments and a wide range of applications to the detection of antigens and single-copy DNA and RNA. It is written in a uniform format, each chapter includes an introduction, materials required, step-by-step detailed methods, results, discussion, and comprehensive up-to-date references.

This new edition includes material that can easily be downloaded to a PDA. Quick and easy to use for clinicians at the touch of a key, this title further incorporates the most up-to-date laboratory methods, techniques, and approaches for designing strategies and investigating the pathophysiology of bone and mineral metabolism. It presents current information in a succinct format that allows practitioners to find answers without delay or difficulty. It brings together up-to-date bone and mineral metabolism methods in one easily, accessible volume and provides a quick reference for bone and mineral disorders. It addresses problems likely to be seen at all ages, from the pre-term infant to the centenarian. It is ideal for practicing physicians, residents, medical students, and researchers.