Oncologia gastroenterologica

Since the publication of the previous edition of Tumors of the Esophagus and Stomach, great advances in many areas of tumor biology have led to a better understanding of the pathogenesis, pathology, and molecular biology of epithelial and stromal malignancies of the upper gastrointestinal tract. Many of these advances have led to specific improvements in diagnosis, prognosis, treatment, and thus, survival in patients affected by these tumors. This edition of the Fascicle was written to highlight these advances, and more specifically, to help pathologists diagnose diseases more accurately and understand how pathology contributes to clinical treatment in the new age of personalized and targeted therapy. Notable advances described in this publication include: 1) expansion of our understanding of the pathologic features and molecular pathogenesis of carcinomas of the esophagus and stomach, most of which develop through a chronic inflammation-metaplasia-dysplasia-carcinoma sequence. Important refinements in the classification of neoplastic precursor lesions have been made since the last AFIP series, including the morphologic and endoscopic subtypes, and this has led to improvements in surgical treatment with a strong trend toward minimization in the form of endoscopic mucosal and submucosal dissections 2) discovery of new diseases, such as gastric adenocarcinoma and proximal polyposis syndrome (GAPPS), a special variant of familial adenomatous polyposis, and significant advances in our knowledge regarding the molecular characterization of genetic polyposis syndromes 3) great expansion in the molecular-pathology correlation, morphologic diversity, classification, and therapeutic options of gastrointestinal stromal tumors (GISTs) 4) reclassification and refinement of prognostic factors related to neuroendocrine tumors 5) improvements in the role of cytology in the diagnosis of tumors of the upper gastrointestinal tract. This book has been written with the pathologist in mind first by using tables that illustrate salient pathologic, molecular, and differential diagnostic features of key entities that are often difficult to distinguish from each other. Specific color photographs of classic tumors and morphologic variants often difficult to recognize are used throughout.

Selected as a Doody's Core Title for 2022 and 2023! Closely mirroring the daily sign-out process, Atlas of Gastrointestinal Pathology: A Pattern Based Approach to Neoplastic Biopsies is a highly illustrated, efficient guide to accurate diagnosis. This practical reference uses a proven, pattern-based approach to clearly explain how to interpret challenging cases by highlighting red flags in the clinical chart and locating hidden clues in the slides. Useful as a daily “scope-side guide,” it features numerous clinical and educational features that help you find pertinent information, reach a correct diagnosis, and assemble a thorough and streamlined pathology report. More than 1,600 high-quality photomicrographs capture the subtle morphologic spectrum of neoplastic processes of the tubular GI tract. Each image is captioned with key diagnostic considerations and includes call-outs showing subtle features and diagnostic clues. Practical tools throughout the text include: Tables that emphasize salient clinicopathologic features, management implications, and therapeutic options o Discussions of how and when to incorporate molecular tools o Checklists for key elements of the diagnostic approach and sample notes for inclusion in pathology reports Relevant endoscopic images, photographs of select gross specimens, and medical figures Brief reviews of normal histology that provide contrast to succeeding patterns “Pearls and Pitfalls” and “Near Misses” sections with lessons from real life sign-out experience “Frequently Asked Questions” sections that discuss common diagnostic dilemmas “Sample Note” sections that offer a template of how to synthesize complicated or especially challenging topics Quizzes in every chapter that provide experience with high-yield, board-style teaching topics Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Volume grande formato (22 x 30) di 190 pagine, numerose illustrazioni a colori, e rilegato con copertina rigida stampata a colori e plastificata. La presente monografia si prefigge come obiettivo prioritario di mettere a disposizione del lettore, le più recenti conoscenze nel vasto campo pluridisciplinare del carcinoma colorettale, in particolare quelle relative all’epidemiologia, alla genetica, alla chemioprevezione, all’anatomia patologica, alla chirurgia, alla radioterapia, alla chemioterapia, alle terapie biologiche ed alle interazioni varie che si determinano velocemente e che sono in continuo sviluppo. Per l’ampiezza delle problematiche affrontate, la monografia è indirizzata allo studente in medicina che voglia approfondire questo specifico argomento, allo specialista oncologo, al chirurgo, al radioterapista, ma anche all’internista, all’epidemiologo ed al medico di base, cultore dell’argomento. In pochi altri tumori come quelli del colon-retto si sono sviluppate in così poco tempo nuove conoscenze biologiche da una parte e nuove strategie terapeutiche innovative dall’altra. Tutto ciò ha determinato un significativo miglioramento per quanto riguarda la prevenzione, la diagnostica da una parte e le strategie terapeutiche dall’altra (sia nelle fasi iniziali che avanzate della malattia). Infatti, negli ultimi 20-30 anni abbiamo assistito ad una rivoluzione nelle conoscenze sui tumori del grosso intestino, nel campo genetico-molecolare, nella ricerca traslazionale, nella diagnostica per immagini, nell’approccio multimodale e nelle terapie chirurgiche, tant’è, fino agli anni ’80 del secolo scorso una monografia sul carcinoma colorettale avrebbe affrontato quasi esclusivamente le problematiche della chirurgia, ad opera delle innovazioni introdotte da grandi maestri quali Lembert, Miles, Hartman, Goligher, Corman, Valdoni, Knight e Griffen, Heald e Ryall. Oggi il ruolo del chirurgo, benché sempre di primaria importanza, è ricollocato in un ambito multidisciplinare e le decisioni successive all’atto operatorio sono subordinate ad un “team” di esperti, in primo piano l’oncologo, che da angolature diverse valutano il tumore. Questo volume ha anche il pregio di voler sottolineare quanto è complessa ma essenziale l’interazione tra terapie chirurgiche e mediche nell’approccio a questi tumori, anche quando siano in fase metastatica, il che era senza dubbio più difficile da affrontare appena qualche anno fa. Ad esempio, oggi si può arrivare, grazie al supporto della terapia biologica, a rendere operabili pazienti che fino alla fine del secolo scorso sarebbero stati giudicati inoperabili in senso oncologicamente radicale. Sono altresì cadute le barriere discriminanti legate al fattore eta` ed a patologie quali l’infezione da HIV, sicché in queste categorie di pazienti la concomitanza di un carcinoma del colon-retto non è più una controindicazione a trattamenti con finalità curative. Inoltre, va ricordato come altri fattori, quali l’alimentazione e l’attività fisica, giochino un ruolo importante nello scenario di questa importante patologia e su tali fattori bisognerebbe intervenire mediante massicce campagne d’informazione volte ad “educare” la popolazione generale.Non bisogna dimenticare i fattori genetici che frequentemente vengono sottovalutati, tenendo conto che spesso i pazienti che si avvicinano per la prima volta all’oncologo, con una diagnosi di cancro del colon-retto, hanno familiari con lo stesso tipo di tumore e mai indirizzati ad uno screening appropriato. Mentre nel tumore della mammella e nel tumore del collo dell’utero le campagne di prevenzione hanno sensibilizzato la maggioranza della popolazione, per quanto riguarda il cancro del colon-retto in Italia siamo a percentuali inferiori al 10% della popolazione che si sottopone a screening. Fortunatamente abbiamo assistito negli ultimi anni a parecchie iniziative regionali per promuovere lo screening del carcinoma colorettale, ma occorre ancora da fare molto, ed anche in tal senso la nostra monografia vuole offrire un contributo culturale.

"Gastrointestinal Oncology" is an evidence-based, practical reference intended to assist in the diagnosis and management of patients with gastrointestinal malignancies. It is designed to be as user friendly as possible and is distinguished by the extremely practical, concrete nature of the information presented and by the multidisciplinary approach adopted. In addition to disease-oriented chapters spanning sites from the esophagus to the anus, non-anatomic subjects such as modern imaging techniques are also addressed. Translational science is supplied where useful in the decision-making process. All of the authors are internationally recognized experts. This book is an ideal resource for oncologists, surgeons, gastroenterologists, and primary-care providers looking for the latest and best information on how to deal with a wide variety of gastrointestinal neoplasms.

Written by a team of expert authors from all members of the multidisciplinary cancer care team, Pancreatic Cancer summarizes our current understanding of the epidemiology, genetics, imaging and treatment of these complex malignancies. Each imaging modality is reviewed, with an emphasis on MDCT, MRI and EUS; the key aspects of image interpretation are covered. Separate chapters focus on diagnosis and staging of ductal adenocarcinoma, cystic pancreatic neoplasms and neuroendocrine tumors; rare neoplasms and benign pancreatic disorders that mimic pancreatic cancer are also considered. All treatment options are discussed in detail, including surgery, chemotherapy and radiation therapy, and the multidisciplinary approach to patients with more advanced disease is fully reviewed. This volume is a state-of-the-art review of current practice and knowledge of pancreatic cancer.

Colorectal cancer is the second most common cause of cancer death in the developed world. The last five years have seen dramatic improvements in the multidisciplinary management of this malignancy. In this volume, experts at the forefront of these advances contribute their knowledge and experience on the major advances that have occurred in diagnosis, staging, preoperative and adjuvant therapy, surgery and follow-up assessment of patients with this disease. Imaging underpins all aspects of the clinical management of colorectal cancer and has been shown to play a critical role in improving outcomes for patients. About the series Each volume in Contemporary Issues in Cancer Imaging - A Multidisciplinary Approach is edited by an expert guest editor, with contributions from all members of the multidisciplinary team, bringing together expertise from many specialties to promote the understanding and application of modern imaging in overall patient management.

Esophageal cancer is a relatively uncommon but highly lethal malignancy. The incidence of adenocarcinoma is rapidly increasing and improved survival will depend on prevention, earlier diagnosis, improved staging and appropriate treatment. The multidisciplinary team approach toward patient care is critical in determining the management of patients with esophageal cancer. This volume provides a detailed review of new endoscopic methods of diagnosis, staging using both conventional and functional imaging and assessment of surgical and medical methods of therapy, providing all members of the team with a detailed overview of the diagnosis and management of this malignancy.

With the advent of endoscopic techniques, the gastrointestinal tract has now become more accessable to clinical investigators. Polyps are amongst the commonest abnormalities biopsed and submitted for histological assessment. The biological behavior of a polyp realtes entirely to its pathological nature and accurate histological diagnosis is therefore vital. While so many textbooks and atlases include polyps in sections on gastrointestinal tumours, none have been so comprehensively devoted to the polyp as Gastrointestinal Polyps. The layout of the book has been desigened sequentially to describe the commoner synonyms when appropriate, the prevalence, the endoscopic/macroscopic appearences and microscopic features followed bya section on the biological behaviour and associated conditions. There is a section on treatment, if applicable, and an invaluable list of key references. Profusely illustrated in full colour throughout, it is designed to be the complete companion: a bench book not only for the practising histopathologist who regularly examines oesophageal, gastric, duodenal and intestinal polyps as part of his or her daily work but also for the endoscopist who regularly biopsies them.