Neurobiologia

Ideal for anyone with an interest in the increasing role of brain imaging in understanding pain perception and pain mechanisms, this unique, full-color resource thoroughly covers technical advances in the field as well as potential new applications. Dozens of worldwide experts first demystify the technological concepts that are crucial for proper understanding and interpretation of neuroimaging findings, then explore new advances in understanding brain mechanisms of pain, in human as well as animal models. Key Features: * Covers key topics in the field, including the historical perspective, technology, animal pain neuroimaging, acute pain, neuroplasticity of chronic pain, chronic pain, pain modulation, ethical conflicts, and future directions* Highlights strengths and weaknesses of specific neuroimaging techniques, and includes divergent views regarding outcomes and implications.* Provides a short commentary from Dr. Apkarian, covering significant advances and unanswered questions.* Ensures that both the experienced scientist and the general clinician will find the information they need to understand the current state of the field as well as potential future directions regarding the interaction between the brain and pain.* Discusses both acute and various chronic pain conditions from a functional/physiological, structural/anatomical perspective, and evaluates the tools with which new therapies should be developed for properly treating and/or preventing pain states.

Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. * Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment* Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain* Illustrated in full color* Each chapter provides in-text summary points, special feature boxes, and research questions* Provides an up-to-date synthesis of primary source material

Traumatic Brain and Spinal Cord Injury comprehensively covers the medical and pathological issues related to neurotrauma and its often devastating consequences. Written by globally renowned experts in the field, both clinicians and researchers will find this book invaluable to update their knowledge. This volume is divided into two sections, one covering the brain, the other the spinal cord. Each section discusses the following topics: * The demographic in the developed and developing world where neurotrauma is witnessing a massive expansion * Major clinical issues including advanced semi-experimental monitoring techniques utilized by neurosurgeons and intensivists and the potential use of identifying markers of tissue injury * Overview of major pathophysiological changes * The development of animal models; successes and limitations * Past, current and future therapeutic strategies including rehabilitative opportunities. Presenting the most up-to-date clinical and experimental research in neurotrauma, this volume is essential reading for neurologists, neurosurgeons, intensive care physicians and rehabilitative physicians.

In The Vestibular System: A Sixth Sense, leading experts present an integrative, comprehensive and innovative look at the sense that Aristotle missed. The vestibular system plays a vital role in everyday life, contributing to a surprising range of functions from reflexes to the highest levels of perception and consciousness. This text not only offers a thorough and fresh review of the basicssensory transduction, the neurophysiology of peripheral and central pathwaysand how vestibular signals are processed in the control of gaze and posture; it significantly moves the discussion forward with its attention to the current research and the field's revolutionary advances, such as the understanding of neural correlates of self-motion and the basis of clinical disorders. In addition, the objective presentation of existing controversies is exciting reading and an extremely important contribution to the text's completeness. Dynamic, intellectually challenging, and unique in its level of integration of the material, this book is essential for anyone interested in understanding the vestibular system.

Almost all bodily functions are dependent on the functioning of the autonomic nervous system - from the cardiovascular system, the gastrointestinal tract, the evacuative and sexual organs, to the regulation of temperature, metabolism and tissue defence. Balanced functioning of this system is an important basis of our life and well-being. This book gives a detailed description of the cellular and integrative organization of the autonomic nervous system, covering both peripheral and central aspects. It brings to light modern neurobiological concepts that allow understanding of why the healthy system runs so smoothly and why its deterioration has such disastrous consequences. This academic reference volume will appeal to advanced undergraduate and graduate students studying the neurobiology of the autonomic nervous system within the various biological and medical sciences and will give access to ideas propagated in psychosomatic and alternative medicines.

With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics, glycomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases. Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation, and more. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists.

The present edition of The Human Central Nervous System differs considerably from its predecessors. In previous editions, the text was essentially confined to a section dealing with the various functional systems of the brain. This section, which has been rewritten and updated, is now preceded by 15 newly written chapters, which introduce the pictorial material of the gross anatomy, the blood vessels and meninges and the microstructure of its various parts and deal with the development, topography and functional anatomy of the spinal cord, the brain stem and the cerebellum, the diencephalon and the telencephalon. Great pains have been taken to cover the most recent concepts and data. As suggested by the front cover, there is a focus on the evolutionary development of the human brain. Throughout the text numerous correlations with neuropathology and clinical n- rology have been made. After much thought, we decided to replace the full Latin terminology, cherished in all previous editions, with English and Anglicized Latin terms. It has been an emotional farewell from beautiful terms such as decussatio hipposideriformis W- nekinkii and pontes grisei caudatolenticulares. Not only the text, but also the p- torial material has been extended and brought into harmony with the present state of knowledge. More than 230 new illustrations have been added and many others have been revised. The number of macroscopical sections through the brain has been extended considerably. Together, these illustrations now comprise a complete and convenient atlas for interpreting neuroimaging studies.