Academic Press Inc

This volume of the "International Review of Neurobiology" was written to assist researchers without any previous experience with in situ hybridization, allowing them to follow the protocols and expect good results. It contains all the information required for newcomers to achieve successful in situ hybridization results, and methods for improving the technique of those already utilizing it. Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

This is the first text to examine the connection between virology and human disease. It is also the first book to integrate basic virology with pathophysiological conditions. By contrast, most virology textbooks focus on the molecular biology involved without adequate reference to physiology. "Viruses and Human Disease" is four-color throughout and contains clearly labeled figures and tables. It provides a concise overview of animal viruses, emphasizing those causing diseases in humans. It integrates discussion of molecular biology, epidemiology, and the history of human viruses. It presents treatment of prions, gene therapy, and vaccine development. It is illustrated in color by an expert virologist. It includes world maps depicting the current distribution of existing and newly emerging viruses.

Written by experts on the forefront of investigations of brain function, vision, and perception, the material presented is of an unparalleled scientific quality, and shows that analyses of enormous breadth and sophistication are required to probe the structure and function of brain regions. The articles are highly persuasive in showing what can be achieved by carrying out careful and imaginative experiments. "The Cat Primary Visual Cortex" should emerge as essential reading for all those interested in cerebral cortical processing of visual signals or researching or working in any field of vision. Key features include: comprehensive account of cat primary visual cortex; generous use of illustrations including color; coverage of research from structure to connections to functions; chapters by leaders in the field; and, topics presented on multiple, compatible levels.

"Febrile Seizures" is written by the most active researchers and clinicians in epilepsy research today. This book presents the latest developments in this field as well as the current state of knowledge in the following fields: new imaging tools and emerging data, visualizing effects of febrile seizures on the brain, new genetic methodologies, and the use of animal models to permit scientific analysis of the electrophysiology and molecular biology of the seizure. Its key feature is that it is the first book on febrile seizures in over 20 years! It covers the broad spectrum of approaches, from genetic and epidemiological to bench research using animal models and in vitro single-cell patch-clamp methods. It contains a comprehensive update of the topic, written by world leaders in the field. It features novel and newly discovered information based on up-to-the-minute methods, and uses an engaging style, that is accessible to the clinician, researcher, and the educated parent.

This book will be a resource for the experienced tissue engineer, a starting point for the student, and a guidebook for the next generation of tissue engineers. Contained in one volume is a comprehensive reference that combines the tools, experimental protocols, detailed descriptions, and "know-how" for the successful engineering of tissues and organs. The practical information contained in the numerous protocols covers every area of tissue engineering and will prove essential to scientists working in this field. Contributions by leaders in the latest areas of research will also be of interest to biotechnological and pharmaceutical researchers. The key features are: provides comprehensive protocols covering every area of tissue engineering, including polymer synthesis, cell culture, encapsulation, bioreactors, therapeutics, and the creation of tissues and organs; and, includes contributions by leaders in the latest areas of research, such as stem cells and fetal tissue engineering.

"Atlas of Ambulatory EEG" is a first-of-its-kind publication in clinical neurophysiology, an atlas that comprehensively depicts normal, abnormal, and artifactual findings from actual ambulatory EEG recordings in a convenient and easily accessible format. As the use of ambulatory EEG has increased in recent years, the need for a concise atlas of ambulatory EEG has grown significantly, since ambulatory EEG tracings are subject to their own unique issues and artifacts, often not discussed in standard EEG atlases.This book begins with several chapters that introduce the history, technology, and clinical utility of ambulatory EEG. The bulk of the atlas consists of a page-by-page display of high-quality ambulatory EEG excerpts that are easy to review and come with short annotations describing the relevant findings."Atlas of Ambulatory EEG" is a critical resource for anyone involved in the interpretation of ambulatory EEG studies. It is a handy reference describing EEG patterns in normal and abnormal subjects based upon continuous monitoring techniques from widely used ambulatory EEG equipment. A section of EEG patterns without accompanying explanation will test the reader's ability to interpret the waveforms and answers will be given in a separate section. It includes an unique accompanying CD, which provides a sample of EEG files. The files have been provided by Digitrace - a company which maintains a vast library of EEG files. It has Internationally renowned contributors in the field. It is suitable for a wide audience including researchers in neurophysiology and neuroscience, as well as neurologists.

Thoroughly updated and in a new two-color format, this well- respected text presents the fundamentals of biochemistry and related topics to students pursuing a one- or two-semester course in pre-med biochemistry or medical programs. The second edition is equally applicable to other health-related fields such as clinical chemistry, medical technology or pharmacology. "Medical Biochemistry, Fourth Edition" focuses on the foundations and clinically relevant applications of normal human biochemistry and pathology. It is abundantly illustrated with four-color plates. It includes revised chapters on molecular biology that reflect the latest research in the field. The reference quality appendices include practical information on clinical lab parameters used to diagnose a range of diseases.

The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by newer agents. "Principles of Clinical Pharmacology" focuses on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. The coverage of these principles in this book will be of particular benefit to individuals engaged either in the teaching or study of sound therapeutic technique or in the investigation of pharmacological agents. Key features include: the unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy; unusual cohesiveness of presentation that stems from author participation in an ongoing popular NIH course; instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study; and, wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry.

Completely revised and expanded, this second edition of The Cytokine FactsBook is the most up-to-date reference manual available for all current well-characterized interleukins, cytokines, and their receptors. An additional 52 cytokines are included, doubling the number of entries from the previous edition. The key properties of each cytokine are described and presented in a very accessible format with diagrams for each of the receptors. The Cytokine FactsBook includes free online access to the regularly updated Cytokine Webfacts. Cytokine Webfacts is a web-based comprehensive compendium of facts about cytokines and their receptors that includes a variety of data representations, such as text, signal pathway diagrams and 3D images. This exciting resource is integrated into other databases via hypertext links to provide a unique network, and contains a web-enabled version of RasMol for viewing structures.

As we enter the 21st century, a new era of nutrition in the prevention and treatment of disease emerges. Clinical nutrition involves the integration of diet, genetics, environment, and behavior promoting health and well being throughout life. Expertly edited, "Nutrition in the Prevention and Treatment of Disease" provides overall perspective and current scientifically supported evidence through in-depth reviews, key citations, discussions, limitations, and interpretations of research findings. This comprehensive reference integrates basic principles and concepts across disciplines and areas of research and practice, while detailing how to apply this knowledge in new creative ways. "Nutrition in the Prevention and Treatment of Disease" is an essential part of the tool chest for clinical nutritionists, physicians, nurse practitioners, and dieticians in this new era of practice. This book prepares the clinical nutrition investigator or practitioner for a life-long commitment to learning. It contains information on: diet assessment methodologies; strategies for diet modification; clinical status of herbals, botanicals, and modified food products; preventing common diseases such as cardiovascular disease, diabetes, osteoporosis, and breast cancer through nutrition; the importance of genetic factors; understanding of cultural and socio-economic influences on eating and exercise behaviors and integrating that knowledge with biological or functional markers of disease.

First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Now edited by J.R. Baker (Royal School of Tropical Medicine and Hygiene, UK), R. Muller (International Institute of Parasitology, UK) and D. Rollinson (The Natural History Museum, UK), supported by an international Editorial Board, Advances in Parasitology includes medical studies on parasites of major influence, such as typanosomiasis and scabies, and reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. Eclectic volumes are supplemented by thematic volumes on such topics as Remote Sensing and Geographical Information Systems in Epidemiology. In 1999, the Institute for Scientific Information released figures showing that Advances in Parasitology has an Impact Factor of 4.913, placing it 2nd in the highly competitive category of Parasitology. This eclectic volume in the serial contains four reviews on the following topics: * Two reviews on the biology of trypanosomes (a parasitic protozoan) and trypanosomiasis (disease caused by the parasite, such as sleeping sickness and Chagas' disease), a topical area in public health, especially in Africa and South America, and much research in epidemiology and molecular biology/biochemistry. * A review summarizing the literature on the biology of Echinostomes (parasitic flatworms), focusing on descriptions and life cycle studies, experimental studies and physiology, and biochemistry and molecular biology. * A review on the importance of apoptosis (programmed cell death) in the interaction between host and parasite--how it is used in both the parasite 'attacking' the host, and in the host's defense mechanisms. This has implications in the evolution of parasite and host systems, and also in identifying the underlying causes of diseases caused by parasites.

This atlas provides a look at the golden hamster brain in stereotaxic coordinates, which is the grid that is used, much like a map, to ensure accuracy within the lab. It provides a pictorial synopsis of what is currently known about the structure and function of the brain, and provides a consistent anatomical definition and nomenclature (labeling) for areas in the brain. This is the first atlas to preset the golden hamster brain in stereotaxic coordinates. The authors use the brain of an adult male golden hamster, the most widely utilized hamster in neuroscience research. The brains of two different hamsters are used. The first brain is sectioned and stained, using cresyl violet, acetylcholinesterase, Sudan black, and NADPH-diaphorase. The second brain is stained using cresyl violet, luxol fast blue, serotonin immunoreactivity, and GABA/benzodiazepine receptor immunoreactivity. The key features include: provides the first atlas of the golden hamster brain, making it more accessible to researchers; presents accurate three-dimensional coordinates for stereotaxic surgery; brings together current information about hamster brain structure; and, promotes the use of the hamster for key areas of study - i.e., visual system development and regeneration and measurement of circadian behavioral rhythms.

Bryce Weir is a high-profile, respected neurologist. Dr. Macdonald is a colleague of Dr. Weir's and is a "rising star" in the field of neurology. This book is the first to cover all aspects of cerebral vasospasm in depth. It takes the reader from the first descriptions of this puzzling and deadly phenomenon to the latest laboratory evidence explaining its pathophysiology. Packed with clinical pearls, it is a must for neurosurgeons, interventional radiologists, neurologists, and neuropathologists. It examines the current understanding of vascular smooth muscle physiology. It provides in-depth overviews of symptoms and treatments. It is written by acknowledged experts on the subject. It is vividly illustrated with beautiful photographs and diagrams. It cites over 4,000 key papers on vasospasms and presents key data in an easy-to-use format.

Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Edited by the Associate Director of Analytical Research and Development for the American Association of Pharmaceutical Scientists, Analytical Profiles of Drug Substances and Excipients brings this information together in one source. The scope of the series has recently been expanded to include profiles of excipient materials.

"Human Growth and Development" pulls together information from leading experts in a variety of fields to create a one-volume resource on the human growth stages, environmental effects, and the research methods scientists should use. This text promises to be a great course-planning guide for instructors in various medical and scientific fields in addition to a thorough reference for further research. It contains: both biological and bio-medical approaches to human development; chapters on research methods of growth data collection; annotated reference lists for every chapter; and tremendous breadth of knowledge within a single source.