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Cancer: Principles & Practice of Oncology: Primer of the Molecular Biology of Cancer

Steven A. Rosenberg, Theodore S. Lawrence
e altri

editore: Lippincott Williams and Wilkins

pagine: 536

Understand and apply the scientific advances that are revolutionizing cancer research and practice with Cancer: Principles and Practice of Oncology: Primer of the Molecular Biology of Cancer. Derived from DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology - widely hailed as the definitive clinical reference in oncology - the second editon of this popular Primer focuses on the molecular biology information that is of critical importance to research scientists and clinical oncologists alike.* Get up-to-date, dependable coverage of every important frontier in aspect of the molecular biology of cancer with contributions from a noteworthy roster of leading scientists and clinicians, featuring an updated version of the classic "Hallmarks of Cancer" by Hanahan and Weinberg* See how molecular biology advances are impacting clinical practice with separate chapters on each of the 19 most common cancer types.* Navigate the challenges and ethical dilemmas of cancer genetics with a thorough section chapters on genetic counseling and genetic testing.Now with the print edition, enjoy the bundled interactive eBook edition, offering tablet, smartphone, or online access to:*Complete content with enhanced navigation* A powerful search that pulls results from content in the book, your notes, and even the web*Cross-linked pages, references, and more for easy navigation*Highlighting tool for easier reference of key content throughout the text* Ability to take and share notes with friends and colleagues*Quick reference tabbing to save your favorite content for future use
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Un medico d'avanguardia. Gianni Bonadonna e la chemioterapia dei tumori

Domenico Ribatti

editore: Carocci

pagine: 125

Gianni Bonadonna è stato un pioniere della ricerca sui tumori e ha rivoluzionato la storia dell'oncologia clinica mondiale. Laureato a Milano, rientrato in Italia nel 1964, dopo un tirocinio al Memorial Sloang Kettering Cancer Center di New York, ha sempre lavorato presso l'Istituto nazionale dei Tumori di Milano, dove nel 1976 è stato nominato direttore della Divisione di Oncologia medica e, successivamente, direttore del Dipartimento di Medicina oncologica. Le sue ricerche di maggior rilievo comprendono le prime valutazioni cliniche sull'efficacia dell'adriamicina, vari studi sulla chemioterapia adiuvante e primaria del carcinoma mammario, sulla malattia di Hodgkin, per il cui trattamento ha messo a punto una nuova combinazione di farmaci, nota come ABVD. Nel 1995, un ictus ha interrotto bruscamente la sua carriera professionale. Nel 2013, ha lasciato definitivamente l'Istituto dei Tumori di Milano, per dedicarsi alle attività della "Fondazione Michelangelo", organizzazione non lucrativa di utilità sociale per l'avanzamento dello studio e della cura dei tumori, che egli stesso ha fondato nel 1999. L'American Society of Clinical Oncology ha istituito il "Gianni Bonadonna Award and Lecture" come riconoscimento dell'importante attività clinico-scientifica svolta dal grande medico. Bonadonna ha ricevuto varie onorificenze nazionali e internazionali e nel 2004 è stato insignito della laurea honoris causa in Medicina dall'Università di Torino.
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CANCER AND ITS MANAGEMET

TOBIAS J. , HOCHHAUSER D.

editore: Wiley-Blackwell

pagine: 608

90,00 76,50

Il male curabile. La sfida di Mauro Ferrari, il matematico italiano che sta rivoluzionando la lotta ai tumori

Michele Cucuzza

editore: Rizzoli

pagine: 227

Ci sono momenti nella vita di ognuno che sembrano segnare la fine, dolori da cui pare impossibile riprendersi. Invece sono l'inizio di grandi imprese. La storia di Mauro Ferrari è eccezionale. Laureato in matematica, dopo un master a Berkeley ottiene un posto di professore associato all'università della California. Si sposa e ha tre figli. Poi, di colpo, la tragedia. La moglie Marialuisa muore di tumore. Da allora Ferrari si dedica anima e corpo alla battaglia contro il cancro, che affronta con un approccio assolutamente originale basato sull'applicazione delle nanotecnologie alla medicina. Ghiandole artificiali capaci di rilevare il cancro e somministrare autonomamente il medicinale; nanovaccini che risvegliano il sistema immunitario; diagnosi effettuate attraverso una semplice analisi delle proteine; robot chirurghi e sofisticati manichini-pazienti su cui fare pratica. Non è fantascienza, ma solo una parte di quanto si sta sperimentando al Methodist Hospital Research Institute di Houston, Texas, diretto da Ferrari, che spiega: "Con la chemioterapia solo una cellula medicinale su 100 mila raggiunge il bersaglio. Noi lanciamo minuscoli missili multistadio simili a quelli usati nei programmi spaziali, carichi di farmaci che centrano solo le cellule tumorali senza disperdere sostanze tossiche nell'organismo". In questo reportage Michele Cucuzza racconta del suo incontro a Houston col professore e la sua équipe di giovani collaboratori provenienti da tutto il mondo.
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Cancer: Principles & Practice of Oncology

Primer of the Molecular Biology of Cancer

Steven A. Rosenberg, Theodore S. Lawrence
e altri

editore: Lippincott Williams and Wilkins

pagine: 456

Drawn from the content of the new Ninth Edition of Cancer: Principles and Practice of Oncology, this unique publication brings together the basic scientific information on the molecular biology of cancer. The format is designed to be useful both to research scientists interested in the study of cancer and to oncologists who need to understand these new developments that are having a profound impact on the care of patients with cancer. Leading scientists and clinicians in the field of molecular biology and clinical oncology have lent their expertise to this project. The text has been divided into two parts. Part I includes thirteen chapters that deal with the general principles of the molecular biology of cancer that provide the basic framework for an understanding of the behavior of cancer cells. Part II includes an up-to-date description of how this new information has affected the understanding of the biology of 19 of the most common cancers, with an emphasis on how these new findings have been translated to impact the management of cancer patients. This distinctive text provides a single concise source of information for scientists and clinicians in this rapidly developing field.
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Biologia molecolare del cancro. Meccanismi, bersagli, terapie

Lauren Pecorino

editore: Zanichelli

pagine: 308

Questo manuale traccia un percorso parallelo tra i concetti fondamentali della biologia molecolare del cancro e le sue promett
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Pharmaceutical Perspectives of Cancer Therapeutics

Ram I. Mahato, Yi Lu

editore: Springer-Verlag New York Inc.

pagine: 712

Pharmaceutical Perspectives of Cancer Therapeutics covers a wide variety of therapeutic approaches including gene therapy, immunological therapy; cancer vaccines; strategy for solid tumors as well as for hematological cancers; methods to suppress tumor angiogenesis and metastasis; development and utilization of relevant animal models; introduction of new concepts such as cancer stem cells and new technologies, such as DNA and tissue microarrays; and RNA interference. In addition, clinical application, the development of DNA diagnosis biomarkers and cancer prevention, as well as the utilization of imaging in cancer therapy are also discussed. The use of synthetic carriers, such as lipids, polymers, and peptides for delivery and targeting of small molecules, proteins, and nucleic acids to cancer cells in vivo are discussed. Pharmaceutical Perspectives of Cancer Therapeutics also includes cancer therapy modality in surgery, chemotherapy, and radiotherapy, as well as in combination or multi-modality, giving our book a more focused view of cancer therapy.
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Il cancro e la ricerca del senso perduto

P. Mario Biava

editore: Springer Verlag

pagine: 129

La malattia tumorale può essere avvicinata con l'obiettivo di uccidere le cellule malate oppure con quello di far fare loro a
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Cancer Chemoprevention

Caroline C. Sigman, Ernest T. Hawk
e altri

editore: Humana Press Inc.

pagine: 568

Despite significant advances in cancer treatment and measures of neoplastic progression, drug effect (or early detection, overall cancer incidence has increased, pharmacodynamic markers), and markers that measure cancer-associated morbidity is considerable, and overall prognosis as well as predict responses to specific therapy. cancer survival has remained relatively flat over the past All these biomarkers have the potential to greatly augment several decades (1,2). However, new technology the development of successful chemoprevention therapies, allowing exploration of signal transduction pathways, but two specific types of biomarkers will have the most identification of cancer-associated genes, and imaging of immediate impact on successful chemopreventive drug tissue architecture and molecular and cellular function is development-those that measure the risk of developing increasing our understanding of carcinogenesis and cancer invasive life-threatening disease, and those whose mo- progression. This knowledge is moving the focus of cancer lation can "reasonably predict" clinical benefit and, therapeutics, including cancer preventive treatments, to therefore, serve as surrogate endpoints for later-occurring drugs that take advantage of cellular control mechanisms clinical disease. Thus far, the biomarker that best measures to selectively suppress cancer progression. these two phenomena is intraepithelial neoplasia (IEN) Carcinogenesis is now visualized as a multifocal, because it is a near obligate precursor to cancer.
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Sintomi "segnale" in oncologia clinica

Fisiopatologia, diagnosi e terapia

Lelli, G.

editore: Monduzzi

pagine: 376

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COX-2 Blockade in Cancer Prevention and Therapy

Randall E. Harris

editore: Humana Press Inc.

pagine: 381

The revelation that aspirin and aspirin-like compounds have notableantineo- plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op- portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical overview documents the scientific discovery ofCOX-2 and the pharma- ceutical development of nonsteroidal anti-inflammatory drugs (NSAIDs) designed for selective COX-2 inhibition. The process by which essential poly- unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and cancer development, and its interruption by COX-2 inhibition, is elucidated. This is followed by a section on the epidemiology of NSAIDs and cancers of the colon and breast, and other anatomic sites. These chapters reflect significant cancer protection owing to the regular use of common NSAIDs such as aspirin and ibuprofen. A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings which show that COX-2 blocking agents produce striking chemopreventive effects against colon cancer and breast cancer as well as other malignancies. Genetic models are presented confirming the critical role of COX-2 in carcinogenesis. Section IV then discusses the molecular biology of COX -2 vis-a-vis the role of COX -2 and, to a lesser extent, COX -1, in modulating a number of important processes in molecular carcinogenesis such as mutagen- esis, cell division, angiogenesis, cell differentiation, and apoptosis.
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Cancer Screening

A Practical Guide for Physicians

George Y. Wu, K. Aziz

editore: Humana Press Inc.

pagine: 342

In Cancer Screening: A Practical Guide for Physicians, a panel of highly experienced clinicians and researchers from around the world present their up-to-date screening techniques for a wide variety of cancers. The techniques range from screening for breast, gynecological, and gastrointestinal cancers, to testing for urogenital, dermatological, and respiratory cancers. In addition to providing the busy practitioner with quick access to guidelines for particular cancers, the epidemiology and biology of the various cancers, as well as the sensitivity and specificity of the methods, are discussed in detail. Authoritative and physician-friendly, Cancer Screening: A Practical Guide for Physicians offers to all internists, oncologists, various subspecialists, and primary care physicians a concise practical review of cancer screening designed specifically for daily use in the consulting room.
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