Ematologia

Il Manuale di Medicina e Chirurgia nasce per offrirti una fonte di studio univoca nella preparazione ai Concorsi SSM e MMG, su

The latest edition of the key haematology text Haematology, the study and treatment of blood and bone marrow disorders, is a rich and complex discipline that consistently produces cutting-edge medical research. Since 1972, Hoffbrand’s Postgraduate Haematology has acted as the foundational overview and reference text for this subject, introducing generations of trainees and medical residents to the pathogenesis, clinical and laboratory features, and management of blood disorders. The eighth edition of Hoffbrand’s Postgraduate Haematology, now with a new editorial team including leading clinicians and researchers, promises to continue this tradition of excellence with a fully updated text. Lavishly illustrated, comprehensive, and thoughtfully referenced, it is an indispensable resource. Readers of the eighth edition of Hoffbrand’s Postgraduate Haematology will also find: Four-color illustrations and photomicrographs of blood cells and tissues throughout to support key topics New sections analysing recent advances in next generation sequencing, genome editing, clonal haematopoiesis, anticoagulant drugs, diagnostic laboratory tools, and more Companion website with downloadable figures and other tools Hoffbrand’s Postgraduate Haematology is ideal for all postgraduate trainees or residents in haematology, as well as for clinicians and practitioners looking for a reference work on the subject and a guide to the latest research.

Atrial fibrillation is the most frequent sustained cardiac arrhythmia, and represents a frequent cause of any ischemic stroke, as well as the leading cause of thromboembolic stroke. Correct approaches of oral anticoagulation are crucial to prevent atrial fibrillation-related thromboembolic events. This book provides practical indications on the strategies of oral anticoagulation for all settings of atrial fibrillation patients. The book is timely, as in particular it delivers information and suggestions on the use of direct oral anticoagulants in a variety of “difficult” clinical contexts derived from research data and their clinical use in the last 15 years. Newest antithrombotic treatments and contemporary non-pharmacological approaches to prevent thrombotic complications in patients with atrial fibrillation are also addressed in the book.

Discover a comprehensive and up-to-date reference resource for bone marrow pathology, complete with an extensive list of references The diagnosis and treatment of bone marrow pathologies is one of the most critical areas of medical research and care. For years, Bone Marrow Pathology has served as the essential reference and teaching tool in the field of haematology, with an authoritative treatment of the subject written by acknowledged leaders in the field. Now fully updated to reflect urgent new changes to the theory and practice of haematology, it promises to serve a new generation of practitioners. In the book, the characteristics and function of normal bone marrow are extensively discussed. Bone marrow pathology, including both aspirate films and trephine biopsy sections, is examined in a clinical context. The content is augmented by discussion of the peripheral blood findings and supplementary bone marrow tests. Readers of the sixth edition of Bone Marrow Pathology will also find: Lavish illustrations with high-quality images of bone marrow and other associated images Incorporation of new classifications including the WHO and International Consensus classifications, as well as new and expanded research areas Emphasis on practical tools including differential diagnosis and common problems and pitfalls A practical, integrated approach to diagnosis Perfect for trainee and consultant haematologists and haematopathologists, Bone Marrow Pathology will also prove itself invaluable for cytogeneticists, molecular geneticists and anyone working in immunophenotyping.

Developed by 149 experts in the field, The International Consensus Classification of Myeloid and Lymphoid Neoplasms provides key information for use at the microscope to assist in arriving at a swift and accurate diagnosis. Drs. Daniel Arber, Michael J. Borowitz, James Cook, Laurence de Leval, John Goodlad, Robert Hasserjian, Rebecca L. King, Hans-Michael Kvasnicka, and Attilio Orazi lead a team of authors who focus on diagnostic criteria and the clinical significance of each disease entity.   Offers up-to-date information developed through a Clinical Advisory Committee (CAC) process that included the authors and editors of the former 3rd, 4th, and revised 4th edition World Health Organization (WHO) classification of hematopoietic and lymphoid tumors Focuses on diagnostic criteria and includes guidelines as to the clinical significance of each disease authored by a clinician expert Provides essential information for pathologists and hematopathologists in practice and in training, as well as oncologists and hematologists who want to better understand the many disease categories that they encounter ,

**Selected for 2026 Doody's Core Titles as an Essential Purchase in Surgical Pathology** Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative information in this fast-changing field. Edited by Dr. Elaine Jaffe and a team of globally renowned, expert co-editors, it offers a wealth of up-to-date information in an easily accessible format, equipping you to deliver more accurate and actionable pathology reports. Comprehensive in scope, this highly illustrated, practical text is a must-have resource for residents and practicing pathologists alike. Helps you navigate the latest changes in the classification of hematolymphoid neoplasms, providing guidance for use of both the International Consensus Classification (ICC) and 5th edition of the WHO classification Incorporates the latest molecular/cytogenetic information, regarding newly recognized entities and the latest diagnostic criteria Provides you with today's most effective guidance in evaluating specimens from the lymph nodes, bone marrow, peripheral blood, and more, with authoritative information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each Details the latest insights on the molecular biology of benign and malignant hematologic disorders Features more than 1,100 high-quality color images that mirror the findings you encounter in practice Uses an easy-to-navigate, templated format with standard headings in each chapter. Includes information on disease progression and prognosis, helping you better understand the clinical implications of diagnosis Shares the knowledge and expertise of new editors, Drs. Lisa Rimsza, Attilio Orazi, and Steven Swerdlow, providing expertise in molecular diagnostics, bone marrow and lymph node biopsies An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date

HOFFBRAND’S ESSENTIAL HAEMATOLOGY The Essentials is an international, best-selling series of textbooks, all of which are designed to support lecture series or themes on core topics within the health sciences. See www.wiley.com for further details. The definitive introductory textbook on haematology, covering basic science, diagnostic testing, clinical features, and patient management Hoffbrand’s Essential Haematology has helped medical students and trainee physicians understand the core principles of clinical and laboratory haematology for more than four decades. Original contributions by leading experts provide authoritative coverage of clinical and laboratory features and management within haematology, including the haematological aspects of systemic diseases, pregnancy, and the neonate. Hundreds of high-quality colour images illustrate various anaemias and white cell disorders, leukaemias, lymphomas and myeloma, bleeding and thrombotic disorders, and other blood diseases. Now in its ninth edition, this classic textbook incorporates current knowledge of the pathogenesis of blood diseases, the 5th WHO (2022) classification of haematological neoplasms, the detection of minimal residual disease, advances in the treatment of benign and neoplastic blood diseases. New sections focus on the haematological consequences of COVID-19 infection and vaccine -induced immune thrombotic thrombocy-topenia (VITT). Additional and expanded chapters describe non-Hodgkin lymphomas, amyloid, and haemophilia. Supported by a companion website with hundreds of MCQs and PowerPoint slides, Hoffbrand’s Essential Haematology, Ninth Edition, remains an indispensable resource for trainee haematologists and physicians.

Leukaemia Diagnosis Authoritative reference on classifying and diagnosing leukaemia, with practical guidance on using various laboratory techniques included Leukaemia Diagnosis is a practical reference on the principles of leukaemia diagnosis and classification that illustrates and explains in a user-friendly way how different laboratory techniques are used to achieve an accurate interpretation. To aid in reader comprehension, over 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma are included, supplemented by histological, cytogenetic and immunophenotyping images. This newly revised and updated Sixth Edition includes recent developments, highlights the growing importance of molecular genetics, and incorporates the recent 5th edition of the WHO guidelines and the International Consensus Classification for leukaemia diagnosis and classification throughout the text. Information on cytogenetic and molecular genetic abnormalities in leukaemia is also included, along with characteristic immunophenotypic characteristics of different categories of leukaemia. Written by world-renowned authors in the field, Barbara Bain and Mike Leach, Leukaemia Diagnosis covers sample topics such as: The nature of leukaemia, cytology, cytochemistry, and the morphological classification of acute leukaemia, with an index of commonly used abbreviations Immunophenotyping and cytogenetic/molecular genetic analysis, and integration of morphological, immunophenotypic and genetic information with the WHO classifications Acute lymphoblastic leukaemia, acute leukaemia of ambiguous lineage, and the myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms Chronic myeloid leukaemias, lymphoid leukaemias of mature B, T, and natural killer cells, and leukaemia diagnosis in resource-poor countries The Sixth Edition of Leukaemia Diagnosis is a highly valuable resource for trainee haematologists and laboratory scientists in haematology and related disciplines. The text also serves as a useful reference and teaching aid for those who already have expertise in this field.

Written by national recognized experts and senior fellows at leading research institutions, including the National Institutes of Health, and edited by Drs. Griffin P. Rodgers and Neal S. Young, The Bethesda Handbook of Clinical Hematology, 5th Edition, is a concise, comprehensive handbook designed for everyday clinical use. Organized in a quick-reference, portable format, it covers the clinical information you need to know for the diagnosis and treatment all of blood and bone marrow disorders. Readable and practical, the Bethesda Handbook features numerous tables, algorithms, illustrations, and bulleted lists throughout to help bridge the gap between cutting-edge science and everyday clinical practice. Provides clinically focused, authoritative, and current guidance in this complex area, logically organized by disease category Discusses the pathophysiology, natural history, risk factors, diagnosis, management, and follow-up of common hematological diseases Features new diagnostic and treatment strategies, updated references, and revised information throughout An ideal resource for practitioners at every level of training: students, residents, and fellows on a hematology or oncology service, as well as internists, hospitalists, family practitioners, pediatricians, and nurse practitioners whose practice includes patients with blood diseases

Gli Autori di questo libro si conoscono e collaborano insieme da moltissimi anni, formando una “squadra” di Specialisti che regolarmente si consultano, aiutano e scambiano nozioni. Tutto ciò sempre con l’obiettivo di studiare e curare le patologie vascolari della circolazione artero-venosa e linfatica con lo scopo di mantenere aggiornati i numerosi Medici che si devono districare tra mille problematiche quotidiane, spesso prevalentemente burocratiche. Questa è anche una occasione per salutare e ringraziare Prof. Giovanni B. Agus, che ci ha prematuramente lasciati a fine agosto e sarà purtroppo un vuoto incolmabile, soprattutto per chi come me lo ha avuto come Maestro per oltre 40 anni, iniziando dalla Scuola di Specializzazione di Chirurgia Vascolare all’Università di Milano. Come sempre e anche in questo libro, lo scopo è di far giungere le nozioni aggiornate pratiche ed essenziali, oggi si usa dire “agili”, che riguardano le patologie della coagulazione del sangue e dei vasi sanguigni, arteriosi e venosi. Viviamo in un’epoca dove internet ed i motori di ricerca sono i principali strumenti di “lavoro e consultazione”, sia da parte dei Medici che dei Pazienti. Se da un lato i primi sono frequentemente obbligati a fare i “tuttologi” i secondi spesso chiedono o suggeriscono trattamenti e terapie sulla base di “notizie lette su motori di ricerca”, e qui nasce e prolifera confusione, che si è intensificata dopo i due terribili anni della pandemia Covid. Lo scopo di questo libro è quindi di trattare il vasto capitolo delle patologie artero-venose ma soprattutto delle terapie mirate cioè sulle categorie di antitrombotici, anticoagulanti ed antiaggreganti, come affermato dallo stesso Titolo. Può essere assurdo, per non dire incredibile, quante volte si creano e tramandano terapie antiaggreganti con lo scopo di ottenere risultati anticoagulanti, e vice versa. Pure sugli antitrombotici c’è una nebulosa che offusca i veri meccanismi d’azione dei farmaci, a tal punto che questi vengono consigliati inappropriatamente. La confusione poi si complica quando non c’è distinzione tra “farmaci ed integratori”. Il problema forse maggiore risulta nell’uso e quindi prescrizione degli anticoagulanti, siano essi quelli iniettivi eparinici che quelli orali di ultima generazione. I Prodotti sono tutti validi, ma è il loro impiego, la posologia, la durata della terapia e la richiesta di esami ematochimici e strumentali inutili, a rendere complicato l’obiettivo primario: la guarigione del Pazienti con la spesa corretta e praticità reciproca per Medico e Paziente. Oggi per un paziente ottenere una terapia adeguata e prolungata, noto anche come “piano terapeutico” può significare un calvario di ore di attesa dopo settimane o mesi per ottenere un appuntamento. Le conseguenze spesso finiscono con sovraccarichi per i Pronto Soccorso. Questo libro racchiude l’esperienza di Professionisti con la conoscenza della Clinica, la Semeiotica e la Terapia sia essa medica, chirurgica o strumentale, con gli adeguati mezzi per raggiungere gli obiettivi e soprattutto evitando perdite di tempo e sprechi economici. Ricordiamoci sempre che non esiste Patologia, qualunque essa sia, che non abbia o potrebbe avere implicazioni o complicanze vascolari e quindi si deve sempre essere pronti ad affrontarle. Questo libro manuale nasce con lo scopo preciso di essere di facile e rapida consultazione anche per i Medici “non vascolari” e aiutarli ad orientarsi verso terapie appropriate.

High-risk acute myeloblastic leukemia (HR AML) is charac­terized by unfavorable biologic and clinical features impairing the efficacy of conventional treatments resulting in less than 40% short-term complete remission (CR) rate and poor median overall survival (OS). In addition, high-risk disease occurs, often, in elderly patients with high comorbidity burden and these findings induce poor tolerability to chemotherapy and reduced eligibility to allogeneic stem cell transplantation (HSCT), the only curative therapeutic option in this setting. Here, leading experts in the field cover all the novel aspects concerning the updated definition, the diagnosis, the management and future perspectives tor HR AML patients. Over the last decade the great progress in molecular and cell biology, medicinal chemistry far drug design and immunology have resulted in the development and approval of a large number of novel therapeutics for patients with AML. Although the definition of HR AML is evolving, the better understanding of the genetic and biological characteristics of leukemic cells and their microenviroment will significantly contribute towards novel therapeutic approaches.

Selected as a Doody’s Essential Title for 2025! Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.  Provides expert coverage of new topics, including COVID-19, palliative care and survivorship, transitioning from pediatric to adult care, and ethical issues in hematology such as management of individuals with religious/cultural objections to transfusion  Integrates WHO classifications of hematologic neoplasms and the latest knowledge in genetics and genomics, and includes focused chapters on hematopoietic cell transplantation, gene therapy, and immunotherapy  Emphasizes four components of diagnosis: the morphology of the peripheral smear, bone marrow, lymph nodes, and other tissues; flow cytometry; cytogenetics; and molecular markers and mutations  Offers fresh perspectives from new section editors Drs. John Leonard (Lymphoma) and Laura Michaelis (Leukemia/MPN), as well as numerous new contributing authors, many of whom provide international viewpoints on hematology  The VST Ebook includes weblinks directly to some of the other major resource centers int he field and also includes review questions in an interactive question bank weblinks to pages at sites such as NIH, ASCO, NCCN, and CancerResearch.org Enrich Your eBook Reading Experience  Read directly on your preferred device(s), such as computer, tablet, or smartphone.  Easily convert to audiobook, powering your content with natural language text-to-speech. 

**Selected for 2026 Doody's Core Titles in Transplantation Surgery** Led by authors from MD Anderson’s Stem Cell Transplantation and Cellular Therapy Department, the world’s largest and highly respected program at the forefront of rapidly advancing treatments in the field, Manual of Hematopoietic Cell Transplantation and Cellular Therapies is a comprehensive, focused reference covering the latest clinical developments and applications of stem cell transplant and cellular therapies for hematologic malignancies and solid tumors. This cutting-edge title, with a majority contribution from the MD Anderson Cancer Center and leading faculty from other academic institutions, covers breakthrough cell-based therapies for various diseases including lymphoma, multiple myeloma, leukemia, and select solid tumor and autoimmune diseases. This unique, definitive resource is essential for hematologists, fellows in hematology and immunotherapy, mid-level providers, pharmacists, and oncologists who refer patients for cell-based therapies. Addresses hematologic conditions including leukemia, lymphoma, and myeloma Offers guidance on hematopoietic cell transplantation for solid tumors Covers basic science principles, clinical aspects, pharmacology, radiation therapy, and disease-specific guidelines, including prevention and management of complications Discusses key topics such as hematopoietic cell collection, bone marrow harvesting, umbilical cord blood transplantation, CAR T-cell therapy, and patient/donor selection and preparation of HCT Features extensive summary boxes, bulleted content, and algorithms throughout for quick and easy reference Offers team-based, clinically-focused coverage from world-renowned leaders in the field An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud

An essential guide and introduction to the diagnosis, treatment and management of disorders across the breadth of clinical haematology Extensively revised, this 5th edition of ABC of Clinical Haematology covers all aspects of contemporary haematology, providing the basic science behind the disease and diagnostic aspects, along with up to date management. The text assumes little prior haematology knowledge, enabling clear understanding by non-experts, including medical students and nurses. Full colour illustrations and text boxes highlighting important learning points together enable more efficient reader comprehension. ABC of Clinical Haematology covers: Iron deficiency anaemia, macrocytic anaemia, hereditary anaemias, polycythaemia vera, essential thrombocythaemia, and myelofibrosis Chronic myeloid leukaemia, acute leukaemias, lymphoma, stem cell transplantation, cellular therapies, adult myelodysplastic syndrome, and myeloma Bleeding disorders, thrombosis, anticoagulation, and paediatric haematology, platelet disorders Amyloidosis, with focus on systemic light chain amyloidosis, and haematological emergencies New tests, treatments, and management solutions that are now available for certain conditions, especially common blood related disorders With contributions from leading experts in their respective fields, ABC of Clinical Haematology, Fifth Edition provides an ideal reference for primary care practitioners and other healthcare professionals working with patients who have blood related problems.

For more than 30 years, the highly regarded Secrets Series® has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Pediatric Hematology & Oncology Secrets, 2nd Edition, offers practical, up-to-date coverage of the full range of essential topics in this dynamic field. This highly regarded resource features the Secrets’ popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style - making inquiry, reference, and review quick, easy, and enjoyable. The proven Secrets Series® format gives you the most return for your time - succinct, easy to read, engaging, and highly effective Fully revised and updated, including discussions of supportive care of children with cancer and psychosocial aspects of care New chapters on Precision Medicine and Systems Biology; Health Equity and Disparities in Pediatric and Adolescent/Young Adult Oncology; Transfusion Medicine; Neoplastic Hematopathology; Hemophagocytic Lymphohistiocytosis; and more Top 100 Secrets and Key Points boxes provide a fast overview of the secrets you must know for success in practice and on exams Bulleted lists, mnemonics, practical tips from global leaders in the field - all providing a concise overview of important board-relevant content Portable size makes it easy to carry with you for quick reference or review anywhere, anytime Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices

Il volume propone un viaggio nel mondo oncoematologico, un dialogo tra professionalità diverse che accoglie la voce dei pazien

Practical Transfusion Medicine Practical Transfusion Medicine, Sixth Edition The pace of change in transfusion medicine is relentless, with new scientific and technological developments and continuing efforts to improve transfusion practice. This sixth edition of Practical Transfusion Medicine has been updated significantly to reflect the rapid changes in transfusion medicine since the fifth edition was published in 2017. The primary purpose of this edition remains the same as the first: to provide a comprehensive guide to transfusion medicine. This book contains more depth of information than standard handbooks on transfusion medicine, whilst being more concise and approachable than a standard reference text. This book covers the principles of transfusion medicine, the complications of transfusion, practice in blood centres and hospitals and clinical transfusion practice. This sixth edition includes a new section on patient blood management, cellular and tissue therapy, organ transplantation and the development of the evidence base for transfusion. It also features a new chapter on transfusion-associated circulatory overload to underline its importance as a complication of transfusion, and a reconfiguration of the section on clinical transfusion practice to allow consideration of the transfusion management of medical, surgical and haematology patients with and without bleeding. This sixth edition of Practical Transfusion Medicine provides accessible and comprehensive coverage of the field of transfusion medicine. It is a standalone text that will be useful to clinical and scientific staff: not only for trainees who require an overview of the field, but also for established practitioners who are involved in some aspect of transfusion medicine and require a comprehensive, accessible reference book.

ROSSI’S PRINCIPLES OF TRANSFUSION MEDICINE Transfusion Medicine impacts patients with hematologic, oncologic, and surgical conditions as well as all areas of critical care medicine and multiple areas of chronic care. This book aims to be the single best source for information related to any aspect or application of Transfusion Medicine. Contributors for the sixth edition have once again been drawn from various scientific, medical, and surgical disciplines. Thus, this book ranges from encouraging and managing donors, to collecting and preserving the blood, to matching it to the appropriate recipient, all the way to its clinical uses. It also extends these concepts to implantable tissue and regenerative medicine. Other sample topics covered within the work include: Contemporary issues in donation and transfusion: patient blood management, clinical and technical aspects of blood administration, and donor and patient Hemovigilance Blood components and derivatives: red blood cell metabolism, preservation and oxygen delivery, blood groups, and composition of plasma Apheresis, transplantation, and new therapies: hematopoietic growth factors, therapeutic phlebotomy and cellular apheresis, HLA antigens, alleles, and antibodies How Transfusion Medicine has been affected by the coronavirus pandemic, the role of pathogen reduction and other modern trends This book serves as a complete and comprehensive resource on Transfusion Medicine for clinicians who prescribe blood, students who expect to enter clinical practice, and for the scientists, physicians, nurses, technologists, and others who assure the quality and availability of blood services.