Academic Press Inc

For neuroscientists, particularly those studying neuroanatomy, neurophysiology, and molecular biology, a detailed atlas of the rat brain is essential for any laboratory. This updated edition of "Brain Maps: Structure of the Rat Brain" provides atlas maps aligned in 3-dimensional space and created using color photomicrographs of histological sections based on a single rat brain. Where other atlases use multiple brains as models, the use of a single brain allows for true 3-D reconstruction. The atlas employs color coding of the major parts of the brain and extends this coding system to the atlas levels, flatmaps, and nomenclature tables for easier reference. With systematic nomenclature tables, references to the primary research literature for all of the structures, coverage of the neuroanatomical methods and mapping, and an accompanying CD-ROM of all of the atlas maps, this is a reference every laboratory should have on-hand. It provides systematic treatment of the anatomy of the rat brain, based on a single brain model. It is updated to reflect new data about brain regionalization. It includes CD-ROM with all of the brain maps.

Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. "Gene Therapy of the Central Nervous System: From Bench to Bedside" represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis. This work presents gene transfer technologies with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells. It discusses preclinical areas that are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis. It includes 'insider' information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use.

"Pediatric Bone" is the first book to be published to deal exclusively with the biology and diseases of bone as they affect children. Rapid advances have been made in our understanding of the mechanisms and factors controlling the growth and development of bone, and these are discussed in detail in this book. Further, the various diseases of bone which are peculiar to children are highlighted and discussed in the light of our current knowledge with regard to the causation, clinical signs and treatment. The book is aimed to provide those clinicians interested in children's diseases and basic scientists with a comprehensive resource covering the various aspects of bone health and disease in children. It is fully referenced providing an appendix of usually difficult to find information on the investigation of pediatric bone disease and reference values. It covers both the physiology of bone and mineral homeostasis in children and diseases in one book. It also includes a CD-ROM of images.

This volume, the first of its kind ever, is designed to provide both laypersons and professionals with a detailed description of the occurrence of each common form of cancer in the ethnically, socially, and environmentally complex milieu of a modern urban complex. The place is Los Angeles County, and the patterns of 72 different malignancies are described according to race, age, sex, social class calendar time (since 1972) and most notably, individual neighborhood, using detailed maps of high risk. The book permits residents to screen the malignancies and identify those of special concern locally, and to identify other communities with similar concerns. The pattern of each malignancy is briefly discussed with reference to background knowledge of causation and the degree to which the observed pattern was expected on that basis. Persons residing outside Los Angeles County will identify patterns likely to prevail in their own communities. Physicians and scientific investigators in California and elsewhere can use the material provided to counsel patients and evaluate the consistency of any specific pattern of occurrence with each specific causal hypothesis. There is a detailed appendix that describes the source of data, provides the basis for the choices made in the production of the volume, and gives a perspective on the search for 'clusters' of malignancy. This title compares different types of cancers with respect to the degree of non-random occurrence. It contains numerous maps detailing the demographic and geographic pattern of cancer occurrence in Los Angeles County. It provides an empirical perspective to the search for disease 'clusters'.

Organogenesis of the kidney has been intensely studied for over a century. In recent years advances in molecular techniques have not only made great inroads into exploring the genetic regulation of this complex process but also began to unravel the molecular basis of many forms of congenital kidney disease. This book is a comprehensive study on these findings and the only book available with such in depth coverage of the kidney. It includes hundreds of color figures depicting key events in all aspects of kidney development and provides full coverage of the genetic and cellular basis of kidney development. It gives an analysis of the genetic basis of the major congenital kidney diseases.

By detailing experimental and basic research, from premalignancy to fully invasive tumors, this book has wide applicability to all human carcinomas. No other group of human cancers is better positioned for the application of recently developed novel and targeted therapies, and this book uniquely presents the unusual opportunities tumors of the head and neck that provide for clinical, translational, and basic science research. Cutting-edge and experimental treatment approaches are presented, along with future strategies and an evaluation of emerging technologies. It presents a multi-disciplinary perspective from authorities in diverse fields. It addresses state-of-the art approaches in cancer research as well as other scientific opportunities in this field, and provides comprehensive yet easily comprehendible source of information.