Oncologia

This concise, but comprehensive textbook sets out all the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology. The fully updated 3rd edition continues to discuss the basis of radiation therapy and presents the principles and significant scientific developments that underlie current attempts to improve the radiotherapeutic management of all cancers. New topics in the 3rd edition include chapters on volume effects in normal tissues and the L-Q approach in clinical practice, with major revisions to sections on cell proliferation, radiation cytogenetics, radiotherapy-related morbidity, hyperfractionation and individualisation of radiotherapy. The book continues to provide invaluable advice for trainee and practising radiation oncologists from a team of internationally respected contributors and draws on the considerable experience of the Editor, gained during his time as Course Director of the annual ESTRO course in Basic Clinical Radiobiology.

This text provides a concise, systematic account of what is currently known about the epidemiology and primary prevention for most forms of human cancer. Early chapters summarize the principles and methods of epidemiology, the biology of cancer, cancer genetics, the emerging potential biomarkers, and the burden of cancer around the world. Then chapters of uniform structure on over 20 types of cancer provide clinical and pathological outlines, descriptive epidemiology, and a comprehensive account of risk factors and their etiological importance. Specific sections address somatic and germ cell mutations that play a role in the occurrence of particular forms of cancer.

This volume provides a deeper understanding of the diagnosis of brain tumors by correlating radiographic image features to the underlying pathology. Theoretical considerations and illustrations depicting common and uncommon imaging characteristics of various brain tumors are presented. All modern imaging modalities are used to complete a diagnostic overview of brain tumors with emphasis on recent advances in diagnostic neuroradiology. The book has been designed as a clinical tool for radiologists and other clinicians interested in the current diagnostic approach to brain tumors.

In developing annual 20 the goal of the editors was to offer a timely critical review of the literature that has appeared in 2001 focusing mainly on novel therapeutic approaches in the areas of drugs and biologics.

Now in its Second Edition, this pioneering classic text contains the most complete discussion of DCIS available in the medical market. It includes a DCIS review and also covers biology, detection, diagnosis, pathology, psychology, and the treatment of the disease. Contributing surgeons, pathologists, radiation and medical oncologists, psychiatrists, and a medical geneticist write chapters in this multidisciplinary and comprehensive book. In cases where applicable, both sides of an issue are presented and followed by a summary or commentary from the editors. New to this edition are the deletion of four previous chapters and the addition of seven new chapters. There is a greater emphasis on screening and early detection that includes the increased role of genetics and molecular biology, as well as therapeutic options. The book also reviews standard treatment practices of many breast centers around the world.

The 7th edition of this classic text delivers comprehensive guidance on all aspects of leukaemia and the myelodysplastic diseases, detailing their aetiology, pathophysiology, diagnosis, treatment and prognosis. Every chapter has been revised and updated to reflect the latest advances and current therapies, including the use of new drugs.

Oncologic emergencies can relate either to the cancer itself or its treatment. As the number of cancer patients receiving treatment is increasing and the number of clinicians encountering emergencies is rising, optimal outcomes in these patients relies on the recognition of early symptoms and signs and the implementation of appropriate therapy. This book covers the broad spectrum of oncologic emergencies in the major systems ranging from cardiovascular emergencies to neurological emergencies, bone problems through to acute pain and psychiatric problems. The acute infectious and haematological emergencies, which are extremely common and life-threatening, are dealt with in detail. Each chapter provides a background to complications and clearly outlines the modern approach to treatment. For ease of reference the book contains algorithms as guidelines for the management of various emergency situations which will be of use to the practising clinician. Written by an international team of experts, Oncologic Emergencies provides clear, accessible guidelines to ensure effective and immediate treatment and management. This book is aimed at trainees in oncology and practising oncologists, and will also appeal to family doctors, specialist nurses and individuals working in emergency medicine.

When the first edition of this book published in 1994, the psychoimmunology of cancer was still emerging as a topic for serious scientific study. Now, less than ten years later, there is a huge quantity of academic literature about the relationships between psychological variables, the immune system and cancer growth, accompanied by a lively popular interest. In this new edition leading specialists have provided broad critical reviews of the different aspects. Part I, which presents the biological background, will be of particular interest to those with technical knowledge of the relevant laboratory based disciplines. It covers mechanisms mediating the effects of psychological status in the immune system, and anti-cancer mechanisms involving the immune system. Part II is clinically orientated, and accessible to a wide audience. Whether psychotherapeutic interventions can help patients live longer, as well as coping better, is obviously the key question and several contributors consider the clinical evidence for this. A new, speculative chapter on the spiritual context of immunity and cancer has also been added. The psychoimmunology of cancer involves many complex issues, understanding of which remains far from complete. However, the contributors, besides reviewing the current state of knowledge and the implications for cancer patients, offer predictions for the future and ideas about further research.

High-dose therapy with allogeneic or autologous stem cell transplantation as well as additional supportive measures have brought important advances in the therapy of malignant diseases.Allogeneic and especially autologous peripheral blood stem cell grafting as opposed to allogeneic bone marrow transplantation is a subject of intensive research. * The scientific papers presented in this volume centre on haematological malignancies.* They are notable among the various current attempts to improve the therapy of cancer.* Novel treatment strategies are described, in which immunological techniques, the introduction of new pharmaceuticals, of biological factors and genetic engineering emerge as promising tools.The volume is a comprehensive account of the Workshop held in April 2001 in Bad Saarow/Berlin, Germany, the 5th of its kind in the past decade. With its international team of authors, the book presents the state of the art in the field of high-dose therapy of malignant and non-malignant diseases.

Cancer in the Nervous System, 2nd edition is a unique text for practising physicians, physicians-in-training, and other health care professionals who work with cancer patients. It is an edited book composed of integrated chapters on the management of specific cancers that affect the brain and spinal cord, the secondary effects of systematic cancers on the central and peripheral nervous system, the psychosocial impact of cancer and approaches to its management, the physical and cognitive rehabilitations of the cancer patient, and approaces to the control of pain in the cancer patient.

Ovarian cancer provides an up-to-date and comprehensive synthesis of clinical management and research progress in the field of epithelial ovarian cancer. The book has its origins in two separate but complementary initiatives. One initiative was a series of reviews commissioned to cover the spectrum of clinical management of ovarian cancer from prevention, screening and diagnosis to surgery, chemotherapy and palliative care. The reviews were invited from an international panel of clinicians with expertise in the management of ovarian cancer. The second initiative was co-ordinated by the Helene Harris Memorial Trust (HHMT) which has organised key biennial meetings on ovarian cancer for the last 12 years. Attendance at the meetings is by invitation to a small group of international authorities on research aspects of ovarian cancer. Setting the clinically focused reviews alongside the HHMT research focused chapters has created a unique book. First, the book is unusually up-to-date and presents recent advances not included in other books in this field. Second, the contents are comprehensive and cover aetiology, pathology, screening, prevention, diagnosis, prognostic techniques, surgery, adjuvant therapy and palliative care. Third, the review chapters are set alongside more detailed coverage of recent clinical and basic science developments. Examples of this are the coverage of familial cancer, prevention, screening, and current therapy which are consequently much more topical and exciting. Fourth, there are sections on 'tumour biology' and 'novel therapies' which have not been covered in comparable books about ovarian cancer. Finally, the contributions are from a representative spectrum of experts from both research and clinical backgrounds and with a truly international perspective.

In Tumor Targeting in Cancer Therapy, Dr. Michel Page and a panel of authoritative experts from the drug industry, clinics, and academia introduce the principles and techniques of tumor targeting and critically survey their applications from laboratory to bedside. By concisely synthesizing the many technical details, the authors illuminate this innovative technique, ranging from the fundamentals of drug targeting and in vivo and in vitro experimentation, to such emerging therapeutic uses as radioimmunotherapy, radioimmunodetection, therapy with cytotoxic antibodies, immunotoxins, enzyme prodrug immunotherapy, and immunotherapeutics with fusion proteins. There are also reviews of targeting tumors with radioimmunoconjugates, photodynamic therapy, and magnetic drugs, as well as discussions of the internalization of antibodies, bioconjugation and biodistribution, the use of cytotoxic drugs, and the pros and cons of targeting by antibody or ligand.

Recent years have witnessed major advances in our understanding of the pathogenesis of benign prostatic hyperplasia and prostate cancer at both the molecular and cellular levels. These developments were based essentially on fundamental research which as yet has not be substantially translated into clinical practice. In parallel, however, important breakthroughs have also been made in the development of new treatments with significant implications for the management of these diseases. The Prostate: New Developments and Concepts brings together experts and specialists in the field to review the advances underlying the mechanisms of proliferation and metastasis at the molecular level and chart the future for more effective modalities in the diagnosis and prognosis of prostate disease.