Libri di Giuseppe Giaccone

Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.

World reknown basic scientists and clinical researchers update the wealth of new molecular knowledge that sees cancer as a 'disease process' involving key regulatory pathways. Emphasizing prevention, early diagnosis, prognosis, and treatment, these authoritative experts from around the world illuminate the variety of molecular markers to be found, interpret what is known about diseased regulatory pathways, and examine those future research directions likely to realize the promise of molecular therapy. From their presentations, readers will gain an understanding of the new processes now available to identify specific molecular targets for optimal therapeutic efficacy. Comprehensive and path-breaking, "Principles of Molecular Oncology, Second Edition" offers both basic and clinical oncologists not only a bold synthesis of the rapid and complex advances in molecular biology that are transforming our knowledge of cancer, but also a highly practical guide to today's strategies for its diagnosis and treatment.

In developing annual 20 the goal of the editors was to offer a timely critical review of the literature that has appeared in 2001 focusing mainly on novel therapeutic approaches in the areas of drugs and biologics.