Oncologia

Il volume è stato pubblicato a cura della AUORL (Associazione Professori Universitari di Otorinolaringoiatria) la quale ha scelto un argomento particolarmente attuale come la biologia oncologica legata ai tumori del distretto cervico-facciale. Ormai tutti sono concordi nel ritenere vicino il momento in cui le scoperte della ricerca di base renderanno necessarie stadiazioni anche molecolari o integrazioni terapeutiche con prodotti offerti dalle biotecnologie ricombinanti. È importante quindi che il clinico o il chirurgo di questi distretti abbiano nozioni di biologia molecolare oncologica per poter affrontare in modo consapevole queste nuove realtà.

This 2nd edition provides up-to-date information on the diagnosis and treatment of cancers of the eye and orbit. The 1st edition has been significantly revised. The most recent data with respect to retinoblastoma, rhabdomyosarcoma, and melanoma are included, and there are a number of chapters by new contributors, lending this edition a more broadly based, international character. The presenting signs and symptoms of tumors are outlined, and indications for the various imaging modalities are analyzed. Treatment techniques, together with their results in respect of survival and local tumor control, are described in detail; throughout, special attention is paid to multimodality therapy. Potential complications of radiotherapy are described, and relevant information is provided on the management of radiation effects. The emphasis is on the need for a holistic approach to the patient that recognizes the wider role of irradiation of the eye now that more careful treatment planning is possible.

There has been an increase in oral cancer, related to the increase in consumption of tobacco, alcohol and other carcinogenic products. There has also been a significant reduction in mortality due to increasing awareness, early diagnosis and advances in treatments. The achievements made in reconstructive surgery have also had an important impact on improvements to the quality of life, and the functions of speech, mastication and swallowing in sufferers. Oral Cancer reviews all the research, clinical and rehabilitation aspects of the treatment of the orofacial cancer patient. Expert guidance is given on appropriate techniques in reconstructive surgery, as well as the latest developments in osseointegrated facial prostheses and speech therapy. This textbook will be of significant value to head and neck surgeons, maxillofacial surgeons, otolarygologists and plastic surgeons involved in oncologic surgery. Oral surgeons, dentists and other members of a dental team who provide care to patients with oral cancer will also find Oral Cancer useful.

This practical and concise publication explains how busy health professionals can integrate emotional support into the services offered to people with cancer. * Helps health professionals to develop the communication skills needed to understand and assist those affected by cancer. * Discusses the social and psychological problems faced by people with cancer. * Gives detailed information about the qualities and skills needed to act as a helper. * Provides practical tips on how to learn the skills discussed.

This book provides information on 28 conditions.

This trusted resource offers in-depth coverage of all aspects of breast cancer, from epidemiology and pathology through surgical and non-surgical management to psychological and legal issues. The meticulously updated and revised "New Edition" provides cutting-edge information on genetics, screening, mammography and sonography, lymphatic mapping and sentinel node biopsy, in situ carcinoma and early invasive carcinoma, biologic response modifiers, reconstruction, and much more!

The revelation that aspirin and aspirin-like compounds have notableantineo- plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op- portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical overview documents the scientific discovery ofCOX-2 and the pharma- ceutical development of nonsteroidal anti-inflammatory drugs (NSAIDs) designed for selective COX-2 inhibition. The process by which essential poly- unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and cancer development, and its interruption by COX-2 inhibition, is elucidated. This is followed by a section on the epidemiology of NSAIDs and cancers of the colon and breast, and other anatomic sites. These chapters reflect significant cancer protection owing to the regular use of common NSAIDs such as aspirin and ibuprofen. A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings which show that COX-2 blocking agents produce striking chemopreventive effects against colon cancer and breast cancer as well as other malignancies. Genetic models are presented confirming the critical role of COX-2 in carcinogenesis. Section IV then discusses the molecular biology of COX -2 vis-a-vis the role of COX -2 and, to a lesser extent, COX -1, in modulating a number of important processes in molecular carcinogenesis such as mutagen- esis, cell division, angiogenesis, cell differentiation, and apoptosis.

In "Cancer Neurology in Clinical Practice", leading neuro-oncologists from around the world comprehensively review the neurologic symptoms that cancer patients experience, and show how they should be interpreted and evaluated. Organized by both symptom and organ, the book carefully describes each diagnostic neurologic entity - from symptomatology to diagnostic studies to management and prognosis - and presents each major type of cancer in terms of it neurologic problems and how they should be handled. The role of surgery, radiation, chemotherapy, and other palliative measures are considered for each type of problem. Multidisciplinary and up-to-date, "Cancer Neurology in Clinical Practice" explains to the busy physicians treating cancer patients the latest findings in neuro-oncology that will help them to focus their differential diagnosis, diagnostic strategy, and treatment plan for the cancer patient with neurologic symptoms and findings.

Cytopathology of Bone and Soft Tissue Tumors provides the practising pathologist with a single reference for describing and illustrating the cytologic features of musculoskeletal tumours. Using fine-needle aspiration (FNA), the approach of this work is encyclopedic: both common and rare lesions are depicted. The chapters on soft-tissue lesions are organized by direction of differentiation. Summaries of clinical findings are given along with the histopathologic and cytologic description. Key diagnostic points (in table form) and a discussion of the differential diagnosis complete each section. The section on skeletal lesions is organized along predominant cell type seen in smears. This approach facilitates grouping of lesions into diagnostically useful categories, allowing the pathologist faced with an unfamiliar lesion to rapidly access the portion of the text most useful for differential diagnosis. Within each chapter, the organization is similar to that within the soft tissue chapters. The introduction discusses technical concerns, limitations of the technique, and a diagnostic approach in both tabular and narrative form. Information on grading of soft tissue sarcomas completes the introduction.