Oncologia

This practical, well-illustrated atlas covers areas ranging from neuroimaging, the use of crush and touch preps during introperative consultation, classic histological features of brain tumors, tumor variants, and a miscellaneous group of challenging tumors.

This book is designed to provide practising GPs with all the information needed to manage cancer patients. It deals with the full range of relevant issues from the point of diagnosis through treatment, recovery, rehabilitation and palliation where appropriate. This book covers the full breadth of cancer care in the community in one easy-to-access volume. In addition to the core text, this volume also contains a wealth of 'extras' which make all the difference, such as helpful tips, self-help strategies for patients, patient experience information, frequently asked questions, and links with quality payments available through the new GMS contract.

Thoroughly updated for its second edition, "Non-Hodgkin Lymphomas" is the definitive textbook on the biology, diagnosis, staging, and treatment of all forms of non-Hodgkin lymphomas. With backgrounds in medical and radiation oncology, molecular biology, and pathology, the editors and contributors provide an international, multidisciplinary approach to the topic. This edition is the first text using the new World Health Organization classification of non-Hodgkin lymphomas. The book offers complete coverage of the most current techniques for diagnosis, staging, and treatment, the approach to specific types of lymphoma, and special problems common to the management of patients with these disorders. A companion Website includes the fully searchable text and downloadable images.

Primary carcinomas of the liver are increasing in incidence in the developed world, probably due to dietary and environmental factors as well as the known role of infective agents such as Hepatitis C. They are usually diagnosed in the advanced stages and carry high morbidity and mortality. This volume summarises the latest developments in imaging of primary hepatic carcinomas, emphasising the multidisciplinary approach to the care of patients. In addition to extensive chapters on the radiological issues surrounding diagnosis and staging of the malignancies, individual chapters on epidemiology, pathology, and surgical and non-surgical treatment options are included. All treatment options are considered for both HCC and cholangiocarcinoma, including newer techniques such as TACE. Only by a well orchestrated multidisciplinary team approach including epidemiologists, diagnostic radiologists, hepatologists, oncologic surgeons, radiation oncologists, and pathologists can these complex malignancies be managed successfully.

Tumori maligni e malattie cardiovascolari rappresentano le prime due cause di morte nei Paesi sviluppati

Gastric adenocarcinoma is the second most common cancer worldwide. It is usually diagnosed at a late stage and prognosis is poor; even with modern diagnostic and treatment methods the 5-year survival is only 10%. Improvements in overall patient survival can only be achieved by earlier diagnosis and by tailored therapeutic strategies based on tumor type, location and stage at presentation. This volume provides a state-of-the-art, integrated diagnostic and therapeutic approach to patient management. The role of the upper GI series, endoscopy, endoscopic ultrasound, MDCT, MRI, and PET/CT in the diagnosis, staging and follow-up of patients with gastric cancer is emphasized. The relative strengths and limitations of these diagnostic examinations will be presented in context with the most recent epidemiologic, pathologic, and therapeutic concepts regarding this tumor. With expert contributions from members of an international multidisciplinary team, this is an invaluable guide to the diagnosis and management of gastric malignancies.

"The Atlas of Breast Surgical Techniques", edited by V. Suzanne Klimberg, MD, presents state-of-the-art visual guidance on today's full range of breast surgery techniques. In this title in Drs. Townsend and Evers' new "Surgical Techniques Atlas" series, esteemed international contributors offer you expert step-by-step advice on a wide array of surgical procedures, including the newest ablative and re constructive approaches, to help you expand your repertoire and hone your operative skills. Color surgical photos, biopsy specimens, and artists' renderings of key anatomy show you what to look for and how to proceed; and online access at expertconsult.com allows you to consult the book from any computer and watch surgical videos demonstrating how to execute key aspects of many procedures.

Each volume in the "Early Detection and Treatment of Cancer Series" is packed with practical, authoritative information designed to cover the full range of diagnostic procedures, including pathologic, radiologic, bronchoscopic, and surgical aspects. You'll be able to determine the safest, shortest, least invasive way to reach an accurate diagnosis; stage the disease; and, choose the best initial treatment for early stages. Based on current evidence in the literature, authors provide clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed to diagnose and stage each type of cancer. Practical, authoritative, and highly-illustrated, this volume in the brand new "Early Detection and Treatment of Cancer" series covers current protocols and the latest advances in diagnostic imaging and molecular and serologic markers for prostate cancer. Apply expert advice on the best 'next-step' plan for different presentations and tips for less invasive protocols. Get clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed for accurate diagnosis and staging. Clear figures, tables, and boxes illustrate step-by-step care of the full range of problems encountered. Better manage your patients with procedural video clips and more on the included CD-ROM. The small size and convenient format make this an ideal purchase for diagnostic reference.

Much of the diversity of head and neck diseases is due to the large number and broad function of the organs within this region. The surgical pathologist must become proficient in this subspecialty area in order to identify and categorize many different subtypes of lesions and diseases, including those affecting the thyroid and salivary glands. This book from the Cambridge Illustrated Surgical Pathology series comprehensively covers all of the methods utilized by pathologists to accurately diagnose diseases affecting all organs in the head and neck region. Coverage is not limited to findings from the light microscope but also includes other genetic, molecular, and immunologic diagnostic modalities, and the unique orientation allows the reader to follow the progression of disease states from incipient to advanced. This book is illustrated with more than 300 color photomicrographs and accompanied by a CD-ROM of all images in downloadable format.

"The Consultant Pathology" series is designed to disseminate the knowledge of expert surgical pathology consultants in the analysis and diagnosis of difficult cases to the full community of pathology practitioners. The volumes are based on actual consultations and presented in a format that illustrates the expert's process of evaluating the case, including indications for consultation, the consultant's findings and comment, and discussion of the entity that amplifies the case description. Each volume in the "Consultant Pathology" series is authored by international experts with extensive case experience in the areas covered. Surgical neuropathology is a challenging arena for many pathologists, due in large part to a relative lack of experience of most pathologists in this area compared to other areas of surgical pathology. "Consultant Pathology: Brain Tumors" is intended to address this need with cases drawn from the surgical neuropathology practices of the authors. This volume provides examples of over 100 brain tumors, running the gamut from the very common to the rare. Each example is presented in a case based format and the wide variety of cases presented covers the entire scope of brain tumors and offers the opportunity to review both the basics for the beginner or relatively inexperienced pathologist and also offers experienced pathologists the chance to see some of the rare entities. Each case is formatted as if it were a consult case and includes a brief clinical history, description of the pathologic findings with numerous illustrations, the line diagnosis, discussion of the entity, and the diagnostic thought process as well pertinent references for further reading. When relevant, current practical applications of immunohistochemistry and molecular pathology are discussed.

Much work over the last two decades has firmly established that loss of cell cycle checkpoint regulation, and resultant unabated cellular proliferation, is an inherent characteristic of cancer. This loss may occur through aberration in any single component involved in signal transduction pathways that orchestrate checkpoint regulation, which may manifest through either a failure to activate the checkpoint or a failure to respond to the activated checkpoint. In normal cells, checkpoint pathways are activated when genetic or cellular homeostasis is compromised, and signals are then transduced to re-stabilize homeostasis, and, failing this, to activate the apoptotic machinery to induce a cellular suicidal response. This implies that both survival and cell death pathways are induced following checkpoint activation, and that the final decision is dependant on the net result of integrating the two sets of signals. It is intriguing that checkpoint pathways are also critical in cancer therapy to provide an apoptotic stimulus when cellular damage induced by the therapeutic agent is detected by the sensor system. Therefore, it is not surprising that failure in pro-survival checkpoint response will render tumor cells hypersensitive to cytotoxics and, conversely, failure in pro-apoptotic checkpoint response will induce genetic instability and/or therapeutic resistance. Understanding the intricacies of checkpoint response is, therefore, central to the design of therapeutic regimen that will enhance antitumor effects. Although early versions of this design entail combination of cytotoxic agents with cell cycle or checkpoint inhibitors, a greater understanding of the concepts could make such combinations clinically more effective. The contributions in this book will consolidate the current state of knowledge on checkpoint responses that may lay the foundation for hypothesis-driven rational approaches in advancing the management of cancer. The immediate attraction of the book to the scientific community is that it represents a timely opportunity to build upon existing concepts of checkpoints to expand our understanding of the inner workings of the critical checkpoint machinery. The present understanding has provided ample appreciation that response to checkpoint activation is manifested through coordinated inhibition of cyclin-dependent kinase (CDK) complexes in G1, S and/or the G2 phase in order to arrest the cell cycle. Kinase inhibition can occur through several mechanisms, including inhibitory phosphorylation of CDK, destruction of the cognate cyclins, and recruitment of CDK inhibitors from the INK and WAF1/CIP1 families. However, the wealth of information from recent discoveries needs to be examined critically to consolidate our conceptual knowledge of checkpoints. At the same time, there is acute awareness in the diversity of checkpoint response between cytotoxic agents, and this serves as a reminder of the magnitude of complexity that is inherent in checkpoint regulation. This volume is intended to bring the cancer research community closer toward an improved understanding of this regulation, how checkpoint abnormalities can impact negatively on cancer therapy, and emerging strategies to target checkpoint response as a therapeutic end-point.

Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being steadily made into understanding why they resist therapies. This makes it an especially opportune time to assemble some of the best investigators in the field to review the "state of the art" in the various arenas that comprise the assault on CNS tumors. The breadth of this effort by the clinical and basic neuro-oncology community is quite simply amazing. To a large extent, it evolves from the knowledge of the human genome and its regulation that has been hard won over the past two decades.