Hepatocellular cancer is the fifth most common cancer, with 600,000 new cases reported each year worldwide. Additionally, exciting changes in the science of HCC in the last four years have turned the practice of diagnosing and treating the disease upside down. In Hepatocellular Carcinoma: Diagnosis and Treatment, Second Edition, the leading experts in the field of HCC thoroughly update and expand upon the critically acclaimed first edition with all the latest developments in the diagnosis and treatment of primary liver cancer. The book details for physicians the diagnostic and therapeutic decision making process for dealing with such problems as incidental tumors in the liver transplant, the role of neo-adjuvant chemotherapy, intra-arterial vs intravenous therapy, the uses of embolization, and the significance of portal vein thrombus. New chapters discuss the introduction into clinical practice of cell cycle growth inhibitors, an expanded knowledge of Genomics and Proteomics, and novel ways of delivering intra-hepatic chemotherapy. This cutting-edge text is a vital resource and must have for today's hepatologists and medical and surgical oncologists.
Etiology and Epidemiology of Hepatocellular Carcinoma...1 Jawad Ahmad and Mordechai Rabinovitz Molecular Mechanisms of Hepatocellular Carcinoma: Insights to Therapy...23 Marie C. DeFrances and George K. Michalopoulos Clinical Features and Diagnostic Evaluation of Hepatocellular Carcinoma...59 David A. Sass and Kapil B. Chopra Pathologic Aspects of Hepatocellular Tumors...77 Hale Kirimlioglu, Anthony J. Demetris, and Michael A. Nalesnick Use of Imaging Techniques to Screen for Hepatocellular Carcinoma...117 Michael P. Ferderle Radiologic Evaluation of Hepatocellular Carcinoma...141 Michael P. Ferderle and Michael J. Payne Percutaneous Ethanol and Acetic Acid Ablation of Hepatocellular Carcinoma...153 Vibhu Kapoor and F. Leland Thaete Radiofrequency Ablation of Hepatocellular Carcinoma...171 Martin Goodman and David A. Geller Hepatic Resection for Hepatocellular Carcinoma...185 Katsuhiko Yanaga, Sadayuki Okudaira, Takashi Kanematsu, and J. Wallis Marsh Liver Transplantation for Hepatocellular Carcinoma...199 C. Andrew Bonham, Martin Goodman, Sydney D. Finkelstein, Igor Dvorchik, and J. Wallis Marsh Interventional Radiology Techniques for Intra-Arterial Chemo-Embolization...215 Nikhil B. Amesur, Albert B. Zajko, and Philip D. Orons Medical Therapy ofHepatocellular Carcinoma...233 Brian I. Carr Radiation Therapy for Hepatocellular Carcinoma...265 Andrew S. Kennedy New Chapters: 1. Live donor liver transplant for HCC. 2. Novel approaches to chemotherapy and embolization. 3. Molecular prognostication. 4. Clinical application of drugs for cell growth control. 5. Psychological factors in HCC treatment. 6. The new therapies and tumor response evaluation Putting It All Together: Practical guidelines And Considerations for Physicians...285 Brian I. Carr, J. Wallis Marsh, and David A. Geller