Oncologia

"Molecular Pathology in Clinical Practice: Oncology" is an authoritative and comprehensive guide that provides the general pathologist in clinical practice, as well as residents and fellows during their training, with the current standard in molecular oncology testing. It addresses all areas of molecular oncology testing including: molecular biology basics, inherited cancers, solid tumors, neoplastic hematopathology, identity testing and laboratory management. The book integrates the latest advancements in the field with the basic principles and practical applications.

Cancer and aging are integrally related. Cancer incidence and mortality increase with age, with most cancer diagnoses and deaths occurring in patients aged 65 and older. The aging of the Baby Boomer population, along with an overall increase in life expectancy, points to a doubling of the U.S. population over age 65 by the year 2030. This demographic shift, combined with the known association of cancer and aging, is expected to bring about a rapid growth in the older cancer-patient population. It is clear that geriatric principles must become part of oncology care. The evaluation and development of treatment recommen- tions for an older adult with cancer can be challenging for many reasons. Tumor biology and response to therapy are affected by age. In addition, age-related factors may impact treatment patterns, tolerance, and efficacy. These age-related factors include functional status declines, comorbid conditions, changes in cognitive function, weakening of organ function, decreases in physiologic reserve, and faltering social support.

This evidence-based text brings together the theory and practice of palliative care. It examines at all aspects of palliative care i.e. psycho social, spiritual and physical in a highly practical way. The evidence base for cancer care has been developed within the Hospice Movement over the past 50 years and, in the main, it transfers across to patients dying of diseases other than cancer. The book addresses the palliative needs of any patient with any disease in any care setting, which gives it a generic approach. This is in line with current government directives. Contributions to care and treatment are considered in a multidisciplinary and complementary way.

Radiation Toxicity: A Practical Guide provides insight into the management of day-to-day aspects of radiotherapy. Most radiation oncologists and radiation oncology nurses spend a large percentage of their time dealing with the effects of radiotherapy. This book describes the biology behind each sites acute and long-term responses to radiotherapy, including the best current knowledge regarding radiation tolerance, and fills a needed void in the literature that is available on radiation oncology.

Addressing a major field of interest for oncologists, cell biologists, and other biomedical researchers, Beyond Apoptosis provides an overview of how different biological mechanisms of cell death, senescence and mitotic catastrophe stop the growth of tumor cells treated with anticancer agents. Written by internationally renowned contributors, this text includes: morphological illustrations, as well as a DVD containing documents and video clips from various time-lapse microscopic studies of cell death and mitotic catastrophe the role and limitations of apoptosis as a determinant of the toxicity of anticancer agents alternative mechanisms of the antiproliferative actions of anticancer drugs and radiation, such as non-apoptotic cell death, cell senescence, and mitotic catastrophe non-apoptotic forms of cell death, such as necrosis, paraptosis, autophagic cell death, and others morphological and kinetic differences of the various forms of cell death

Interventional oncology has joined surgical, radiation, and medical oncology as the fourth pillar of cancer care. Advances in imaging and image guidance for the detection, characterization, targeting, and therapy of cancer now allow for minimally invasive image-guided treatment of many solid tumors without the morbidity of open surgery or the toxicity of chemotherapy and radiation. The editors have brought together the accrued experience of pioneers and leaders in image-guided cancer therapy from around the globe to create the first comprehensive text for this emerging field. Covering the biology, techniques, clinical applications, and outcomes of interventional oncologic procedures for the treatment and palliation of solid tumors throughout the body, this practical reference will be indispensable for physicians across specialties who seek to provide collaborative, leading-edge care to cancer patients.

"Radiation Oncology: An Evidence-Based Approach (ROEBA)" is a reference book designed to enable radiation oncologists, including those in training, to make diagnostic and treatment decisions on the basis of the best available scientific evidence. Ease of use is ensured by a structured, reader-friendly format that offers rapid access to evidence-based recommendations. "ROEBA"'s orientation is entirely practical, in that the focus is solely on diagnostic/staging and treatment issues. Detailed diagnostic and therapeutic guidelines are provided for multidisciplinary cancer management as well as radiation therapy techniques. The evidence underlying each recommendation is clearly and concisely explained, and the strength of the recommendations and evidence is systemically graded. Furthermore, diagnostic and treatment algorithms are provided for the commonly diagnosed cancers. This ground-breaking text on radiation oncology is an essential tool for physicians in their daily clinical practice.

Orthopaedic Oncology: Diagnosis and Treatment is a complete reference for handling the full range of musculoskeletal tumors frequently encountered in the clinical setting, from osseous tumors in the upper extremity, to soft-tissue tumors of the pelvis. The first section presents the principles of initial assessment, guiding the clinician through key questions for developing the differential diagnosis and selecting the imaging modality and surgical technique. The second part of this book presents sarcoma case reports that cover tumor pathologies in different anatomic locations. Each case report contains succinct descriptions of presenting history, differential diagnosis, anatomic and imaging issues, biopsy techniques, pathologic diagnosis and grading, treatment options, surgical details, preferred treatment, pearls, and pitfalls. Features: * A comprehensive collection of cases presented according to anatomic location * Special emphasis on the significance of a tumor's initial presentation and its implications for surgical treatment * Clinical insights for tailoring treatment plans to the patient's particular condition, such as determining when neoadjuvant chemotherapy and adjuvant chemotherapy are indicated * Current information about the use of positron emission tomography (PET) for tumor grading * Recommendations for avoiding complications and managing potential pitfalls * More than 300 images and illustrations that demonstrate key concepts This book is an indispensable resource for orthopedists, oncologists, as well as radiologists and pathology specialists treating patients with bone and soft-tissue tumors.