Oncologia

"Neuro-Oncology" - a new title in the "Blue Books of Practical Neurology" series - is a concise and clinically applicable guide to this dynamic subspecialty. Jeremy Rees, PhD, MRCP and Patrick Y. Wen, MD present the most current information on the treatment and management of primary CNS tumors, secondary brain tumors, and the neurological complications of other cancers and their therapies in a format and scope appealing to both the general neurologist and the subspecialist.

The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation methods to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorigenesis, cancer researchers can uncover a series of new discoveries and biological insights. The First Cancer Systems Biology Book Designed for Computational and Experimental Biologists Unusual in its dualistic approach, Cancer Systems Biology discusses the recent progress in the understanding of cancer systems biology at a time when more and more researchers and pharmaceutical companies are looking into a systems biology approach to find drugs that can effectively be used to treat cancer patients. Includes Contributions from more than 30 International Experts Part I introduces basic concepts and theories of systems biology and their applications in cancer research, including case studies of current efforts in cancer systems biology. Part II discusses basic cancer biology and cutting-edge topics of cancer research for computational biologists. In contains an overview of genomics, cell signaling, and tumorigenesis, in addition to hot topics like molecular mechanisms of cancer metastasis and the molecular relationships between solid tumors, their microenvironments, and tumor blood vessels. Rounding out the book's solid coverage, Part III explores a variety of computational tools and public data resources that are useful for studying cancer problems at a systems level. Cancer systems biology is still in its infancy as a field of study, but it is fast becoming indispensable in the battle to defeat cancer and develop successful new treatments. Cancer Systems Biology marks an important step toward reaching that goal.

Nel 2000, è iniziato un processo educativo che ha portato a una rivoluzione culturale, educativa e sanitaria nel campo della m

Elsevier now offers a series of derivative works based on the acclaimed Meyler's Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing biomedical researcher and/or clinician. There has been significant progress in the development of targeted therapy drugs that act specifically on certain cancers, and that minimize damage to normal cells. Oncologists and cancer researchers will rely on this volume to determine effective drug treatments. * The only drug guide that includes clinical case studies and expert analysis * UNIQUE! Features not only anticancer drugs, but also all other drugs that act upon related organ systems affected by cancer * Most complete cross referencing of drug-drug interactions available * Latest content from the most highly regarded compilation of drug side effects: Side Effects of Drugs Annual serial

"Handbook for Principles and Practice of Gynecologic Oncology" provides a practical, comprehensive yet concise guide for fellows, residents, and specialist trainees in the diagnosis and management of gynecologic cancers. The book is easy to read and designed for quick reference, with streamlined data to support treatment recommendations. The chapters have been condensed from the key chapters in "Barakat, Markman and Randall's Principles and Practice of Gynecologic Oncology", Fifth Edition and are consistently organized to move from incidence to etiology to diagnosis and treatment. Helpful algorithms and reference tables are included where appropriate. Key points appear in shaded boxes within each chapter.

Worldwide, breast cancer is by far the most common cancer amongst women, with an incidence rate more than twice that of colorectal cancer and cervical cancer and about three times that of lung cancer. Whilst screening programmes have improved detection, this disease still places a very high burden on healthcare services worldwide. Over the last two decades, improved public awareness, the implementation of population screening by mammography, and the development of new technology for diagnosis have transformed the care of patients with breast cancer. In this volume, recognised experts discuss key current issues in the diagnosis and management of breast disease. The development and application of new diagnostic techniques is described as well as the use of sophisticated drugs for more effective treatment. Complex contentious topics including risk factors, borderline lesions, professional performance and quality assurance are thoroughly explored by an expert multidisciplinary team.

The consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists and others who treat cancer patients, Cancer Medicine 8 covers the ever-widening sphere of current cancer knowledge and clinical practice. In this new 8th edition an outstanding editorial team from world-renowned medical centers continues to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology, imaging and therapy. The book is a testament to the editorial panel's creed that innovative, comprehensive, multidisciplinary treatment of cancer patients must be grounded in a fundamental understanding of cancer biology. Cancer Medicine 8 does a superb job of bringing scientific principles into clinical practice. This text is the ultimate resource of new information providing the basis for better informed cancer therapy choices. Cancer Medicine 8 features hundreds of 4-color illustrations, photographs, tables, graphs and algorithms that make this text an invaluable clinical tool in recognizing characteristic appearances of both patient and tissue. The 137 tightly focused chapters are organized into 5 sections: I: Cardinal Manifestations of Cancer II: Scientific Foundations of Cancer III: Principles of Cancer Diagnosis IV: Principles of Therapeutic Modalities V: Principles of Multidisciplinary Management Major Revisions: Chapter 6: Oncogenes An entire section is devoted to oncogenes like kit, Ret, Braf, Akt genes and the new drugs that specifically target them. This chapter not only provides a list of these new therapies but also insight as to how they target the oncogenes and their mutations, as well as therapy response and efficacy. Chapter 11: Tumor Angiogenesis This chapter provides a wealth of new data and understanding of the mechanisms of angiogenesis and how it contributes to the malignancy of various cancers The Clinical Advancement section provides an extensive summary of new trials investigating numerous novel angiogenesis agents Chapter 33: Chemoprevention This chapter also provides a considerable amount of new information for a broad range of clinical trials such as the HPV vaccine trial Future, Select, Star, Approve and PreSAP. The rationales for these trials are discussed and resulting data from the completed trials are presented. Chapter 55: Cytokines Research on cytokines is another area that is exploding in magnitude. This chapter presents a wealth of new information on promising new therapeutic agents.There is also updated information on the therapeutic usage of currently available agents such as hemotopoietic growth factors (HGF), erythropoietin and thromobopoietic agents. Chapter 56: Monoclonal Serotherapy A considerable amount of research has been done in the past few years on therapeutic and targeted agents in cancer therapy. Updated information and data is provided from recent trials for therapies previously discussed in Cancer Medicine edition 7 covering therapeutic agents and targeted toxins. Chapter 77: Neoplasms of the Head and Neck There is a discussion of changes in treatment methods for certain cancers such as the recent shift from surgery to combined chemotherapy with radiotherapy for tonsillar cancer, nasal and paranasal sinuses cancers and laryngeal cancer. Chapter 78: Lung Cancer Advances in diagnostic techniques are described such as ultrasound-guided fine needle aspiration or electromagnetic navigation diagnostic bronchoscopy. Video assisted thoracoscopic surgery (VATS) discussion is updated. New sections are devoted to prognostic and predictive biomarkers.

Knowledge about the etiology and diagnosis as well as treatment concepts of neu- oncologic diseases is rapidly growing. This turnover of knowledge makes it dif? cult for the physician engaged in the treatment to keep up to date with current therapies. This book sets out to close the gap and pursues several innovative concepts. As a comprehensive text on neuro-oncology, its chapters are interconnected, but at the same time some chapters or subdivisions are so thoroughly assembled that the whole volume gives the impression of several books combined into one. Neuropathology is treated in an extensive and clearly structured section. The int- ested reader ? nds for each tumor entity the latest well-referenced consensus rega- ing histologic and molecular pathology. Through this "book-in-the-book" concept, information on neuropathology is readily at hand in a concise form and without ov- loading the single chapters. Pediatric neuro-oncology differs in many entities from tumors in adult patients; also, certain tumors of the CNS are typically or mainly found only in the child. Therefore, pediatric neuro-oncology was granted its own, book-like section. Tumor entities that are treated differently in children and adults are included both in the pediatric neuro-oncology section and in the general section. Entities that typically occur only in the child and adolescent are found in the pediatric section in order to avoid redundancies.

Il nuovo paradigma concettuale e operativo dell'oncologia si chiama Green Oncology. Superato il tradizionale modello biomedico centrato sull'interesse del singolo paziente e sul suo rapporto esclusivo con il medico, la Green Oncology promuove un paradigma etico più evoluto e complesso. Secondo questo modello le azioni critiche sono frutto della partecipazione dei pazienti, vengono condivise tra i vari operatori sanitari e sono ecoresponsabili rispetto all'impatto attuale e futuro sull'ambiente umano, professionale, strutturale, tecnologico e organizzativo in cui si originano, nonché sulla biosfera.

La sedazione del dolore non può essere considerata come un compito sussidiario del personale sanitario, ma assume rilevanza etica e deontologica, oltre che clinica. Il trattamento del dolore oncologico implica il passaggio dal concetto di curare al concetto di prendersi cura, spostando l'attenzione dalla malattia al malato. Su tali convinzioni si basa questo manuale di facile consultazione, per infermieri e studenti che si trovano a gestire il trattamento sia farmacologico che fisico del paziente con dolore. Il volume, dopo aver trattato i vari tipi di dolore, la loro incidenza e la loro valutazione, ne analizza i meccanismi neurofisiologici. Ampio spazio è dedicato alle schede di presentazione dei farmaci più usati dei quali sono descritti, oltre alla composizione qualitativa e quantitativa, indicazioni terapeutiche e controindicazioni, modi e precauzioni d'uso, effetti indesiderati. In appendice viene anche riportata e presentata la più recente normativa, particolarmente rilevante per tutte le figure professionali impegnate nell'assistenza e oggetto di specifica attenzione da parte delle istituzioni che si occupano di politica sanitaria.

Questo testo, finalizzato al recupero di una visione antropologica dell'assistenza medica e infermieristica, si rivolge agli studenti delle Facoltà di Medicina di ogni profilo, agli studenti delle Facoltà di Scienze della formazione e ai professionisti della salute e della formazione. Alla sua stesura hanno contribuito esperti delle Associazioni AMO (Associazione italiana infermieri di oncologia) e CIPOMO (Collegio dei primari oncologi medici ospedalieri) e altri professionisti appartenenti all'Istituto italiano di Bioetica, in particolare antropologi, psicologi, bioeticisti, sociologi ed esperti in diritto e di aspetti biolegali.

In 2002, Lippincott published the Manual of Breast Diseases, edited by Professor Ismail Jatoi. The current book, Management of Breast Diseases, is an adaptation of that manual, with Professor Manfred Kaufmann of the Goethe-University of Frankfurt serving as co-editor. Most of the chapters from the original manual have been either extensively revised or discarded, and several new chapters added. This text contains more material than the original manual, but it is still intended as a basic guide for the wide spectrum of clinicians (surgeons, gynecologists, oncologists, radiation onco- gists, internists, general practitioners) who treat breast diseases, both benign and malignant. To compile this text, we assembled experts from throughout the world. Thus, this text provides not only a broad overview of breast diseases, but also highlights diff- ent perspectives from different parts of the world. Yet, it is worth noting that the management of breast cancer is now largely predicated on evidence-based medicine. Several large, randomized prospective trials have demonstrated the ef? cacy of breast cancer screening and chemoprevention. Other large trials have addressed the impact of systemic therapy, radiotherapy, and variations in local therapy on breast cancer mortality. Many of these landmark trials are discussed in this text, and they clearly have had a bene? cial effect. Indeed, since about 1990, breast cancer mortality rates have declined substantially in most industrialized countries, and this trend is expected to continue in the years ahead.