This text provides a comprehensive guide to anticoagulation in the hospital setting. Designed specifically for use by hospital-based clinicians and associated hospital-based staff (nurses, nurse practitioners, physician assistants), the book addresses the most commonly used anticoagulant agents and primary indications for their use. In addition, this evidence-based book carefully reviews the epidemiology and treatment of complications associated with anticoagulants, addresses the use of anticoagulants in special populations, discusses new advances in anticoagulation, and finally, discusses how to develop programs related to improving the administration and safety of anticoagulants.
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Preface vii Contributors ix 1. Pharmacology of Parenteral Anticoagulants 1 Kathleen H. McCool and Daniel M. Witt 2. Pharmacology of Vitamin K Antagonists 25 Jaekyu Shin and Steven R. Kayser 3. Antiplatelet Medications 47 Michael Kornfeld and Joseph R. Munsayac 4. Newer Oral Anticoagulants 67 Taki Galanis and Geno J. Merli 5. Prevention of Venous Thromboembolism in Medical Patients 81 Alex C. Spyropoulos and Charles E. Mahan 6. Prevention of Venous Thromboembolism in Surgical Patients 107 Nancy Torres Finnerty and Franklin Michota 7. Treatment of Acute Venous Thromboembolism in Hospitalized Patients 137 Tracy Minichiello, Lauren Doctoroff, and Elizabeth A. Farrell 8. Perioperative Management of Oral Anticoagulants and Antiplatelet Agents 161 Ramiro Jervis and Andrew Dunn 9. Prevention of Cardioembolic Stroke 179 Ali Mahajerin and Warren J. Manning 10. Antithrombotics for Ischemic Stroke 205 Fadi B. Nahab and Sakib Qureshi 11. Antithrombotic Therapy for Non-ST-Elevation Acute Coronary Syndrome 223 David Lao and Andrew Boyle 12. Parenteral Anticoagulants: Special Considerations in Patients with Chronic Kidney Disease and Obesity 241 Sarah A. Spinler, Millie Rajyaguru, Julie K. Atay, and John Fanikos 13. Hemorrhagic Complications of Anticoagulants in Hospitalized Patients 291 Allison Burnett, Jason Cohen, and David A. Garcia 14. Heparin-Induced Thrombocytopenia 331 David Feinbloom and John Fani Srour 15. Transitions in Care: Inpatient Anticoagulation 361 Neil Gupta, Diane Sliwka, and Margaret C. Fang 16. Optimizing Inpatient Anticoagulation: Strategies for Quality Improvement 377 Greg Maynard, Ian Jenkins, Brian Clay, Michael Montazeri, and Doug Humber Index 415
