With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics, glycomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases. Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation, and more. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists.
Indice testuale
1. INTRODUCTION Microarrays in Translational Neuroscience - from Laboratory to Clinical Applications 2. REACTIONS OF PERIPHERAL NERVE TO TRAUMATIC INJURY AND AXON REGENERATION The Potential of Genomewide Expression Profiling in Models of Peripheral Nervous System Injury and Repair Largescale Screening for Regeneration-Associated Neural Proteins and Genes Patterns of Genetic Regulation and Target Remodelling in Response to Molecular Signals to Neurons Microarray Analysis to Decipher Peripheral Nerve Myelination Unravelling the Mechanism of Neuropathic Pain using cDNA Arrays Comparison of Axotomy-induced Neuronal Gene Expression Profiles in Regenerating Peripheral Nerve and Non-regenerating CNS Fiber Tract 3. CENTRAL NERVOUS SYSTEM TRAUMA AND NEURODEGENERATION Single Cell Gene Expression and cDNA Microarray Analysis to Study Molecular Events in TBI, Neurological Degeneration and Restoration Gene Expression Changes Induced by Blocking or Ablation of Nogo A in Spinal Cord Injury and Brain Microarray Hybridization to Search for Genes Involved in Inhibition and Promotion of Spinal Cord Regeneration Proteomics Technology Applied to Traumatic Brain Injury: Implications for the Identification of Diagnostic Predictors and New Therapeutic Targets Molecular Changes in Neurodegenerative Disorders and Oxidative Stress Responses in Brain Injury Proteomics in Molecular Medicine: Applications to CNS Diseases 4. GLYCOMIC TECHNOLOGIES APPLIED TO NERVOUS SYSTEM FUNCTION Glycomic Approaches to Analyze Neural Functions of Glacosaminoglycans and Proteoglycans Glycoproteomics and Glycan Profiling: Implications for Nervous System Function and Repair
