Wiley-VCH Verlag GmbH
Tutti i libri editi da Wiley-VCH Verlag GmbH
Handbook of Therapeutic Antibodies
Technologies, Emerging Developments and Approved Therapeutics
Stefan Dubel
editore: Wiley-VCH Verlag GmbH
pagine: 1250
Antibodies are an essential part of the immune system in vertebrates. Their generation involves a random mutation and rearrangement process and they can be in principle directed against any biological compound. In the last years biotechnological processes have been developed allowing for the selection of any antibody with a specific target and the subsequent large scale production of this antibody. This most comprehensive reference source for the development, production and therapeutic application of antibodies is now available as a paperback edition. It includes general chapters presenting established technologies and clinical applications, chapters on emerging technologies, new therapeutic concepts, and clinical studies and detailed and specific information about currently approved therapeutic antibodies, including clinical data. This is a must-have resource for academic researchers and decision makers in the industry, as well as healthcare professionals in the clinic.
Medical Biostatistics for Complex Diseases
Frank Emmert-Streib , Matthias Dehmer
editore: Wiley-VCH Verlag GmbH
pagine: 412
A collection of highly valuable statistical and computational approaches designed for developing powerful methods to analyze large-scale high-throughput data derived from studies of complex diseases. Such diseases include cancer and cardiovascular disease, and constitute the major health challenges in industrialized countries. They are characterized by the systems properties of gene networks and their interrelations, instead of individual genes, whose malfunctioning manifests in pathological phenotypes, thus making the analysis of the resulting large data sets particularly challenging. This is why novel approaches are needed to tackle this problem efficiently on a systems level. Written by computational biologists and biostatisticians, this book is an invaluable resource for a large number of researchers working on basic but also applied aspects of biomedical data analysis emphasizing the pathway level.
Atherosclerosis
Molecular and Cellular Mechanisms
Jason Johnson , Sarah Jane George
editore: Wiley-VCH Verlag GmbH
pagine: 420
Covering the most devastating disease in the Western world, this handbook and ready reference provides a comprehensive account of the different stages and factors in the development of the atherosclerotic plaque. Each chapter is written by experts in the field and highlights the role of specific mediators of atherosclerotic plaque development, as well as potential therapeutic targets. A large amount of this up-to-date information is conveyed by way of tables and schematic figures, in a readily comprehensible manner. A must-have for master and PhD students, researchers, MDs and lecturers in vascular biology and cardiology, as well as for academics and scientists in the pharmaceutical industry.
Epigenetics and Human Health
Linking Hereditary, Environmental and Nutritional Aspects
Alexander Haslberger , Sabine Gressler
editore: Wiley-VCH Verlag GmbH
pagine: 316
After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.
Diagnostic Samples
From the Patient to the Laboratory
Bernd Zawta
,
Hermann Wisser
e altri
editore: Wiley-VCH Verlag GmbH
pagine: 124
This fourth, updated edition contains the latest developments in preanalytical knowledge. An international team of authors summarizes the information on biological influences, analytical interferences and on the variables affecting the collection, transport and storage, as well as preparation of samples. In so doing, they cover age, gender, race, pregnancy, diet, exercise and altitude, plus the effects of stimulants and drugs. National and international standards are described for sampling procedures, transport, sample identification and all safety aspects, while quality assurance procedures are shown for total laboratory management. In addition, this practical book is rounded off by a glossary explaining all terms being used. This book is a must-have for everyone involved in patient care and using or performing laboratory tests.
Sepsis and Non-infectious Systemic Inflammation
From Biology to Critical Care
Christophe Adrie , Jean-Marc Cavaillon
editore: Wiley-VCH Verlag GmbH
pagine: 446
Providing definitions, clinical features and epidemiology, this handbook and reference adopts a comprehensive approach, describing in detail the various physiological systems involved. As such, it is the first to combine sepsis and non-infectious SIRS, reviewing both the biological and medical aspects of these two important syndromes. The whole is rounded off with a discussion of past, present and future therapies.
Neural Degeneration and Repair
Gene Expression Profiling, Proteomics and Systems Biology
Hans Werner Muller
editore: Wiley-VCH Verlag GmbH
pagine: 249
With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics, glycomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases. Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation, and more. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists.
Neurotransmitters and Neuromodulators
Handbook of Receptors and Biological Effects
Oliver Von Bohlen Und Halbach , Rolf Dermietzel
editore: Wiley-VCH Verlag GmbH
pagine: 402
A complete update of the highly acclaimed handbook with data on all neurotransmitters and the majority of neuromodulators. The coverage is now even more comprehensive, with 15% more entries on neuropeptides, "classic" neurotransmitters and related substances in a clear, alphabetical format. The methodological section has been expanded by 50% and now includes color figures, plus new chapters on genomics, proteomics, databases, microarrays, MALDI-TOF, neutrophins, FGF, endocannabinoids and neuroimaging. The text provides clearly structured information on the biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system, with all substances uniformly treated for an easy comparison of data. Furthermore, introductory chapters on receptors, transporters, and the blood-brain barrier make this an indispensable tool for researchers, teachers, and advanced students, as well as a must-have for every neuroscientist.
A Statistical Approach to Genetic Epidemiology
Concepts and Applications
Andreas Ziegler , Inke R. Konig
editore: Wiley-VCH Verlag GmbH
pagine: 361
'There are not so many books on statistical methods focused on genetic epidemiology. This contribution fills a gap with a good selection of topics presented in a concise format that will be useful for biostatisticians starting in the field and geneticists or epidemiologists that want to master the specialized statistics used in genetics' - "ISCB NEWS". Covering the latest developments, this advanced textbook introduces the relevant statistical methods applied in this field. This title provides a concise introduction to genetic fundamentals. It explains both linkage analysis and association analysis in detail. It features more than 100 problems and solutions. It includes a foreword by Robert C. Elston, Director, Division of Genetic and Molecular Epidemiology at the Case Western Reserve University, Cleveland, Ohio. Written by the prize-winning scientist Andreas Ziegler, President of the German Region of the International Biometric Society, and Inke Koenig, who contributes several years of teaching experience, this is an ideal text for all epidemiologists, geneticists, statistics specialists, biomathematicians, and graduate students.
Nutritional Genomics
Impact on Health and Disease
Hans-Georg Joost , Regina Brigelius-Flohe
editore: Wiley-VCH Verlag GmbH
pagine: 470
"Nutritional Genomics" paves the way for novel applications in medicine and human nutrition, and this volume presents the latest data on how genetic variation is associated with dietary response and how nutrients influence gene expression. In doing so, it brings together the various disciplines involved in this field of research, making this essential reading for nutritionists, biochemists and molecular biologists.
Organometallics
Christoph Elschenbroich
editore: Wiley-VCH Verlag GmbH
pagine: 804
The textbook on organometallic chemistry. Comprehensive and up-to-date, the German original is already a classic, making this third completely revised and updated English edition a must for graduate students and lecturers in chemistry, inorganic chemists, chemists working with/on organometallics, bioinorganic chemists, complex chemists, and libraries. Over one third of the chapters have been expanded to incorporate developments since the previous editions, while the chapter on organometallic catalysis in synthesis and production appears for the first time in this form.
The Chemistry of Heterocycles: Structure, Reactions, Synthesis, and Applications
Theophil Eicher , Siegfried Hauptmann
editore: Wiley-VCH Verlag GmbH
pagine: 632
Basic One- and Two-Dimensional NMR Spectroscopy
editore: Wiley-VCH Verlag GmbH
pagine: 418
This is the fifth edition of the highly successful, classic textbook for bachelor and master courses, with over 20 % new material and the contents completely revised and updated.Using a minimum of mathematics, it explains the underlying theory of this most important spectroscopic technique in a thorough, yet readily understandable way, covering instrumentation and interpretation of the spectra. It presents all students need to know about 1D, 2D-NMR, solid state and dynamic NMR spectroscopy, as well as NMR imaging, all illustrated by examples for maximum clarity. All the sections include sub-chapters that focus on applications taken from organic, macromolecular, polymer and biochemistry.A must for students and lecturers in chemistry, biochemistry, pharmacy, and life sciences, as well as for spectroscopists.
Introduction to Elementary Particles
David Griffiths
editore: Wiley-VCH Verlag GmbH
In the second, revised edition of a well-established textbook, the author strikes a balance between quantitative rigor and intuitive understanding, using a lively, informal style. The first chapter provides a detailed historical introduction to the subject, while subsequent chapters offer a quantitative presentation of the Standard Model. A simplified introduction to the Feynman rules, based on a "toy" model, helps readers learn the calculational techniques without the complications of spin. It is followed by accessible treatments of quantum electrodynamics, the strong and weak interactions, and gauge theories. New chapters address neutrino oscillations and prospects for physics beyond the Standard Model. The book contains a number of worked examples and many end-of-chapter problems. A complete solution manual is available for instructors.
