Endocrinology Enables readers to form an integrated understanding of endocrine physiology by examining the mechanisms of action of medical therapies
Endocrinology: Pathophysiology to Therapy is a comprehensive resource on medical therapies; in each chapter, the relevant endocrine physiology of the medical therapy is presented, followed by a review of the detailed mechanism of action of selected medical interventions. Where applicable, emphasis is placed on clinical pharmacology pearls, such as side effects and therapeutic monitoring guidelines.
Supplementary chapters address additional topics, including immune checkpoint inhibitor-related endocrinopathies, anabolic steroid abuse, pseudo-endocrine conditions, and dynamic tests in clinical endocrinology. Rather than emphasizing guideline-defined treatment protocols, this??book directs attention towards the pathophysiology and fundamental principles of endocrine therapies.
Categories of therapies covered in Endocrinology include:
Pituitary gland therapies, including Cushing’s disease, Acromegaly, Prolactinoma, adult growth hormone insufficiency, central diabetes insipidus, and syndrome of inappropriate ADH secretion
Thyroid gland therapies, including Hashimoto’s thyroiditis, Graves’ Disease, Thyroid Eye Disease, Riedel’s thyroiditis, Thyroid hormone resistance, and RSH secreting tumors
Adrenal gland therapies, including primary adrenal insufficiency, primary hyperaldosteronism, classic congenital adrenal hyperplasia, and nonclassic congenital adrenal hyperplasia
Pancreatic gland therapies, including diabetes mellitus, neuroendocrine tumors, and hypoglycemia syndromes such as somatostatin analogs and calcium channel blockers
Discussing the rationale for using various therapies and enabling readers to appreciate complex concepts in a clinically relevant manner, Endocrinology is an essential reference for practitioners in related fields looking for an accessible and comprehensive resource on the subject.
Endocrinology: Pathophysiology to Therapy is a comprehensive resource on medical therapies; in each chapter, the relevant endocrine physiology of the medical therapy is presented, followed by a review of the detailed mechanism of action of selected medical interventions. Where applicable, emphasis is placed on clinical pharmacology pearls, such as side effects and therapeutic monitoring guidelines.
Supplementary chapters address additional topics, including immune checkpoint inhibitor-related endocrinopathies, anabolic steroid abuse, pseudo-endocrine conditions, and dynamic tests in clinical endocrinology. Rather than emphasizing guideline-defined treatment protocols, this??book directs attention towards the pathophysiology and fundamental principles of endocrine therapies.
Categories of therapies covered in Endocrinology include:
Pituitary gland therapies, including Cushing’s disease, Acromegaly, Prolactinoma, adult growth hormone insufficiency, central diabetes insipidus, and syndrome of inappropriate ADH secretion
Thyroid gland therapies, including Hashimoto’s thyroiditis, Graves’ Disease, Thyroid Eye Disease, Riedel’s thyroiditis, Thyroid hormone resistance, and RSH secreting tumors
Adrenal gland therapies, including primary adrenal insufficiency, primary hyperaldosteronism, classic congenital adrenal hyperplasia, and nonclassic congenital adrenal hyperplasia
Pancreatic gland therapies, including diabetes mellitus, neuroendocrine tumors, and hypoglycemia syndromes such as somatostatin analogs and calcium channel blockers
Discussing the rationale for using various therapies and enabling readers to appreciate complex concepts in a clinically relevant manner, Endocrinology is an essential reference for practitioners in related fields looking for an accessible and comprehensive resource on the subject.
Indice testuale
Preface xix
Acknowledgments xx
CHAPTER 1 Pituitary Gland Therapies 1
1.1 Cushing's Disease 1
1.2 Acromegaly 10
1.3 Prolactinoma 15
1.4 Adult Growth Hormone Insufficiency 19
1.5 Central Diabetes Insipidus 22
1.6 Syndrome of Inappropriate ADH Secretion 28
CHAPTER 2 Thyroid Gland Therapies 43
2.1 Hashimoto's Thyroiditis 43
2.2 Graves' Disease and Thyroid Eye Disease 51
2.3 Riedel's Thyroiditis 60
2.4 Thyroid Hormone Resistance 61
2.5 TSH-Secreting Tumors 64
2.6 Thyroid Cancer 65
CHAPTER 3 Adrenal Gland Therapies 83
3.1 Primary Adrenal Insufficiency 83
3.2 Primary Hyperaldosteronism 91
3.3 Pheochromocytomas and other Paraganglioma Syndromes 96
3.4 Classic Congenital Adrenal Hyperplasia 103
3.5 Nonclassic Congenital Adrenal Hyperplasia 106
CHAPTER 4 Pancreatic Gland Therapies 122
4.1 Diabetes Mellitus 122
4.2 Neuroendocrine Tumors 148
4.3 Hypoglycemia Syndromes 154
CHAPTER 5 Parathyroid Gland and Bone Therapies 171
5.1 Primary Hyperparathyroidism 171
5.2 Hypoparathyroidism 176
5.3 Paget's Disease of Bone 184
5.4 X-Linked Hypophosphatemia 186
5.5 Osteoporosis 189
CHAPTER 6 Reproductive Organ Therapies 215
6.1 Polycystic Ovary Syndrome 215
6.2 Male Hypogonadism 230
6.3 Menopause 238
6.4 Turner's Syndrome 242
CHAPTER 7 Therapies in Disorders of Lipid Metabolism and Obesity 256
7.1 Hyperlipoproteinemia Syndromes 256
7.2 Obesity 271
7.3 Lipodystrophy Syndromes 280
CHAPTER 8 Miscellaneous Topics in Disorders of Endocrine Glands 295
8.1 Recent Technological Advances in Diabetes Care 295
8.2 Immune Checkpoint Inhibitor-Related Endocrinopathies 299
8.3 Pseudoendocrine Conditions 301
8.4 Drugs of Abuse with Endocrine Side Effects 303
CHAPTER 9 Dynamic Tests in Clinical Endocrinology 313
9.1 Pituitary Gland 313
9.2 Disorders of the Thyroid Gland 323
9.3 Disorders of the Adrenal Glands 326
9.4 Disorders of the Pancreas 329
9.5 Disorders of the Reproductive Organs 332
Appendix A 343
A.1 Cardiovascular Outcome Trials in Diabetes Care 343
A.2 Common Side Effects of Endocrine Treatments (Board Review) 344
A.3 Brand Names of Common Medications in Endocrinology 346
Index 348
Acknowledgments xx
CHAPTER 1 Pituitary Gland Therapies 1
1.1 Cushing's Disease 1
1.2 Acromegaly 10
1.3 Prolactinoma 15
1.4 Adult Growth Hormone Insufficiency 19
1.5 Central Diabetes Insipidus 22
1.6 Syndrome of Inappropriate ADH Secretion 28
CHAPTER 2 Thyroid Gland Therapies 43
2.1 Hashimoto's Thyroiditis 43
2.2 Graves' Disease and Thyroid Eye Disease 51
2.3 Riedel's Thyroiditis 60
2.4 Thyroid Hormone Resistance 61
2.5 TSH-Secreting Tumors 64
2.6 Thyroid Cancer 65
CHAPTER 3 Adrenal Gland Therapies 83
3.1 Primary Adrenal Insufficiency 83
3.2 Primary Hyperaldosteronism 91
3.3 Pheochromocytomas and other Paraganglioma Syndromes 96
3.4 Classic Congenital Adrenal Hyperplasia 103
3.5 Nonclassic Congenital Adrenal Hyperplasia 106
CHAPTER 4 Pancreatic Gland Therapies 122
4.1 Diabetes Mellitus 122
4.2 Neuroendocrine Tumors 148
4.3 Hypoglycemia Syndromes 154
CHAPTER 5 Parathyroid Gland and Bone Therapies 171
5.1 Primary Hyperparathyroidism 171
5.2 Hypoparathyroidism 176
5.3 Paget's Disease of Bone 184
5.4 X-Linked Hypophosphatemia 186
5.5 Osteoporosis 189
CHAPTER 6 Reproductive Organ Therapies 215
6.1 Polycystic Ovary Syndrome 215
6.2 Male Hypogonadism 230
6.3 Menopause 238
6.4 Turner's Syndrome 242
CHAPTER 7 Therapies in Disorders of Lipid Metabolism and Obesity 256
7.1 Hyperlipoproteinemia Syndromes 256
7.2 Obesity 271
7.3 Lipodystrophy Syndromes 280
CHAPTER 8 Miscellaneous Topics in Disorders of Endocrine Glands 295
8.1 Recent Technological Advances in Diabetes Care 295
8.2 Immune Checkpoint Inhibitor-Related Endocrinopathies 299
8.3 Pseudoendocrine Conditions 301
8.4 Drugs of Abuse with Endocrine Side Effects 303
CHAPTER 9 Dynamic Tests in Clinical Endocrinology 313
9.1 Pituitary Gland 313
9.2 Disorders of the Thyroid Gland 323
9.3 Disorders of the Adrenal Glands 326
9.4 Disorders of the Pancreas 329
9.5 Disorders of the Reproductive Organs 332
Appendix A 343
A.1 Cardiovascular Outcome Trials in Diabetes Care 343
A.2 Common Side Effects of Endocrine Treatments (Board Review) 344
A.3 Brand Names of Common Medications in Endocrinology 346
Index 348
