Oncologia

Introducing the definitive gynecologic oncology reference and surgical atlas - in one essential text, "Gynecologic Oncology: Clinical Practice and Surgical Atlas" brings together a skill-sharpening reference and full-color atlas to deliver an unmatched introduction to the field. As the most comprehensive, evidence-based gynecologic oncology resource available, this all-in-one resource offers high-yield coverage of the discipline's underlying principles and proven management strategies. Each topic is written by experts and is presented in an easily accessible, consistent presentation that highlights clinical practice guidelines, along with the diagnosis and treatment of specific malignancies. This authoritative coverage is reinforced by the state-of-the-art surgical atlas, which offers a richly illustrated, overview of essential procedures designed to build your knowledge and confidence. This title features a consistent, streamlined presentation for each disease that consists of: Epidemiology, Pathology, Clinical Presentation, Diagnosis, Staging, Treatment, Survival, Key management strategies. It offers thorough examination of basic gynecological oncology topics, including epidemiology, clinical trial design, biostatistics, genetics and biology of gynecologic cancers, and diagnostic modalities. It is instructive; A-to-Z coverage of disease sites - from cervical cancer and gestational trophoblastic disease, to epithelial ovarian cancers and breast cancer and emphasizes evidence-based practice guidelines and critical supporting data. It offers in-depth, hands-on look at clinical management topics. It provides an up-to-date survey of perioperative and critical care; the principles of chemotherapy, radiation therapy, and immunotherapies; and, quality of care and quality of life. It features full-color design filled with more than 600 figures, tables, algorithms, color photos, and illustrations. Key points helpfully review the main topics to be covered in specific chapters, while chapter conclusions offer convenient summaries of each chapter's core concepts. Chapter-ending references underscore the book's evidence-based approach.

Although many tumors of the upper respiratory tract are squamous cell carcinomas, the varied tissues of this region can give rise to a bewildering array of neoplasms. This text reviews the interpretation of biopsies of neoplasms and neoplasm-like entities arising in the head and neck region, including the ear. It will discuss both neoplastic and non-neoplastic pathology to help make the correct diagnosis and guide patient management.

Here's the multidisciplinary guidance you need for optimal imaging of malignancies. Radiologists, surgeons, medical oncologists, and radiation oncologists offer state-of-the-art guidelines for diagnosis, staging, and surveillance, equipping all members of the cancer team to make the best possible use of today's noninvasive diagnostic tools.

This international primer on psycho-oncology spans settings of care as well as regional boundaries. Designed to be easy to read, with informaton clearly displayed in concise tables and boxes accompanied by clinical vignettes, the book provides clear, practical guidance on all aspects of the psychological care of patients with cancer. Both trainees and practitioners will find it useful in the clinic as well as a resource for continued professional development.

"Perry's The Chemotherapy Source Book", now in its fifth edition, provides information on the choice of chemotherapeutic agents, the use of combination chemotherapy, and the toxicity of individual drugs. Organized by site, this is the only book of its kind to focus strictly on the clinical practice of chemotherapy, and is meant to serve as a "one-stop shop" for information on choice of chemotherapeutic agents, treatment outlines, grading of side effects, and dose modification.

The first edition of this book was the first authoritative, systematic and comprehensive text to define the increasingly important and evolving specialty of paediatric palliative care. It explores both the clinical aspects and the multidimensional and holistic nature of care for the dying child, based on the knowledge that all human experience has a physical, emotional, psychological and spiritual impact. The book covers ways of providing support in all of these areas both for the child, families, and carers, recognising the importance of teamwork and taking an evidence-based approach. The Oxford Textbook of Palliative Care for Children is about the care of children for whom cure of their underlying disease is not possible. It encompasses the physical management of symptoms such as pain and nausea, as well as social issues such as accessing appropriate education, emotional issues such as techniques for communication, and spiritual issues such as feelings of guilt and isolation. The book suggests that if we are to maintain the quality of life for a child it is essential to recognise all these dimensions and try to address them. This can only be done by recognising the skills of a wide range of professionals and working together in ways that are not always intuitive to any one discipline. It explores the multidimensional and holistic nature of care for the dying child. Those working in paediatric palliative care recognise that all human experience has emotional, psychological and spiritual impact as well as physical, and this book offers the essential information needed for those involved in paediatric care to find ways of providing support in all of these areas. Comprehensive in scope, exhaustive in detail, and definitive in authority, this second edition has been thoroughly updated to cover new practices, current epidemiological data and the evolving models that support the delivery of palliative medicine to children. Paediatric palliative care is now developing in countries with differing health care systems, and being adapted to suit individual illnesses and the varying resources and geography in different parts of the world. This book is an essential resource for anyone who works with children worldwide.

Ci sono momenti nella vita di ognuno che sembrano segnare la fine, dolori da cui pare impossibile riprendersi

"Diagnostic Pathology: Neuropathology" is the newest title in the popular "Diagnostic Pathology" series by Amirsys. This extensively illustrated book showcases nearly 1,700 high-quality pathology images, including a variety of pathology stains and professionally designed medical illustrations. Utilizing the classic Amirsys bulleted text format, essential information is condensed for fast and easy comprehension while the Key Facts section provides quick reference to the most critical considerations. In this must-have guide, expert neuropathologists carefully help the reader identify crucial elements of each diagnosis along with hundreds of potential differential diagnoses. This handsome volume will serve as a valuable go-to resource for pathologists needing expert guidance in neuropathology.

This is a concise and updated review of prostate cancer pathologic diagnosis with emphasis on practical issues and recent developments in the field. Each chapter addresses the basic diagnostic features, differential diagnoses, pitfalls and ways to resolve the problem. Additionally, a brief introduction of prostate cancer screening, clinical management and treatment are summarized. Recent development of immunohistochemistry, molecular testing in the diagnosis, prognosis and treatment are also reviewed. Finally, current knowledge of molecular alteration of prostate cancer carcinogenesis and impact in diagnosis and treatment are discussed.

"Operative Techniques in Orthopaedic Surgical Oncology" provides full-color, step-by-step explanations of all operative procedures in orthopaedic oncology. This text contains the chapters from the oncology section in Sam W. Wiesel's "Operative Techniques in Orthopaedic Surgery". Written by experts from leading institutions around the world, this superbly illustrated volume focuses on mastery of operative techniques and also provides a thorough understanding of how to select the best procedure, how to avoid complications, and what outcomes to expect. Accompanying the book is a companion website with the fully searchable text and procedural videos. The user-friendly format is ideal for quick preoperative review of the steps of a procedure. Each procedure is broken down step by step, with full-color intraoperative photographs and drawings that demonstrate how to perform each technique. Extensive use of bulleted points and tables allows quick and easy reference. Each clinical problem is discussed in the same format: definition, anatomy, physical exams, pathogenesis, natural history, physical findings, imaging and diagnostic studies, differential diagnosis, non-operative management, surgical management, pearls and pitfalls, postoperative care, outcomes, and complications.

Volume grande formato (22 x 30) di 190 pagine, numerose illustrazioni a colori, e rilegato con copertina rigida stampata a colori e plastificata. La presente monografia si prefigge come obiettivo prioritario di mettere a disposizione del lettore, le più recenti conoscenze nel vasto campo pluridisciplinare del carcinoma colorettale, in particolare quelle relative all’epidemiologia, alla genetica, alla chemioprevezione, all’anatomia patologica, alla chirurgia, alla radioterapia, alla chemioterapia, alle terapie biologiche ed alle interazioni varie che si determinano velocemente e che sono in continuo sviluppo. Per l’ampiezza delle problematiche affrontate, la monografia è indirizzata allo studente in medicina che voglia approfondire questo specifico argomento, allo specialista oncologo, al chirurgo, al radioterapista, ma anche all’internista, all’epidemiologo ed al medico di base, cultore dell’argomento. In pochi altri tumori come quelli del colon-retto si sono sviluppate in così poco tempo nuove conoscenze biologiche da una parte e nuove strategie terapeutiche innovative dall’altra. Tutto ciò ha determinato un significativo miglioramento per quanto riguarda la prevenzione, la diagnostica da una parte e le strategie terapeutiche dall’altra (sia nelle fasi iniziali che avanzate della malattia). Infatti, negli ultimi 20-30 anni abbiamo assistito ad una rivoluzione nelle conoscenze sui tumori del grosso intestino, nel campo genetico-molecolare, nella ricerca traslazionale, nella diagnostica per immagini, nell’approccio multimodale e nelle terapie chirurgiche, tant’è, fino agli anni ’80 del secolo scorso una monografia sul carcinoma colorettale avrebbe affrontato quasi esclusivamente le problematiche della chirurgia, ad opera delle innovazioni introdotte da grandi maestri quali Lembert, Miles, Hartman, Goligher, Corman, Valdoni, Knight e Griffen, Heald e Ryall. Oggi il ruolo del chirurgo, benché sempre di primaria importanza, è ricollocato in un ambito multidisciplinare e le decisioni successive all’atto operatorio sono subordinate ad un “team” di esperti, in primo piano l’oncologo, che da angolature diverse valutano il tumore. Questo volume ha anche il pregio di voler sottolineare quanto è complessa ma essenziale l’interazione tra terapie chirurgiche e mediche nell’approccio a questi tumori, anche quando siano in fase metastatica, il che era senza dubbio più difficile da affrontare appena qualche anno fa. Ad esempio, oggi si può arrivare, grazie al supporto della terapia biologica, a rendere operabili pazienti che fino alla fine del secolo scorso sarebbero stati giudicati inoperabili in senso oncologicamente radicale. Sono altresì cadute le barriere discriminanti legate al fattore eta` ed a patologie quali l’infezione da HIV, sicché in queste categorie di pazienti la concomitanza di un carcinoma del colon-retto non è più una controindicazione a trattamenti con finalità curative. Inoltre, va ricordato come altri fattori, quali l’alimentazione e l’attività fisica, giochino un ruolo importante nello scenario di questa importante patologia e su tali fattori bisognerebbe intervenire mediante massicce campagne d’informazione volte ad “educare” la popolazione generale.Non bisogna dimenticare i fattori genetici che frequentemente vengono sottovalutati, tenendo conto che spesso i pazienti che si avvicinano per la prima volta all’oncologo, con una diagnosi di cancro del colon-retto, hanno familiari con lo stesso tipo di tumore e mai indirizzati ad uno screening appropriato. Mentre nel tumore della mammella e nel tumore del collo dell’utero le campagne di prevenzione hanno sensibilizzato la maggioranza della popolazione, per quanto riguarda il cancro del colon-retto in Italia siamo a percentuali inferiori al 10% della popolazione che si sottopone a screening. Fortunatamente abbiamo assistito negli ultimi anni a parecchie iniziative regionali per promuovere lo screening del carcinoma colorettale, ma occorre ancora da fare molto, ed anche in tal senso la nostra monografia vuole offrire un contributo culturale.

Handbook of Clinical Neurology: Neuro-Oncology, Part I summarizes the present state of scientific and clinical knowledge in the field of neuro-oncology, including information related to diagnostic techniques such as imaging, along with immunology, molecular biology, and clinical aspects of tumors. Management and new therapeutic strategies for tumors, including gene therapy and molecularly targeted treatments, are also covered. Divided into eight sections encompassing 61 chapters, the book begins with an overview of the basic principles of tumors, including the epidemiology of primary central nervous system tumors, angiogenesis and invasion in cancer, the link between blood-brain barrier and brain edema, and the role of stem cells in gliomas. It proceeds with a discussion of diagnostic tools such as neuroimaging, the principles of tumor therapy such as radiotherapy and immunotherapy, and clinical trials in neuro-oncology. The reader is also introduced to specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. Furthermore, the book explains the neurological complications of systemic cancer and complications from treatments. This volume will appeal to clinicians and neuroscientists as well as researchers who want to gain a better understanding of the clinical features and management of the neurological manifestations of tumors. * An invaluable resource that includes critical, in-depth insights into recent developments in neuro-oncology * A fresh perspective on molecular biology, immunology, and other clinical aspects of tumors of the nervous system * Extensive coverage of tumor management and new therapeutic strategies, including gene therapy and molecularly targeted treatments * New tactics and therapies that will aid clinicians in their quest to provide optimal care for their neuro-oncological patients

Handbook of Pain and Palliative Care:Biobehavioral Approaches for the Life Course Rhonda J. Moore, editor This book takes both a biobehavioral and a lifespan approach to understanding long-term and chronic pain, and intervening to optimize patients' functioning. Rich in clinical diversity, chapters explore emerging areas of interest (computer-based interventions, fibromyalgia, stress), ongoing concerns (cancer pain, low back pain), and special populations (pediatric, elderly, military). This coverage provides readers with a knowledge base in assessment, treatment, and management that is up to date, practice strengthening, and forward looking. Subject areas featured in the Handbook include: a- Patient-practitioner communication a- Assessment tools and strategies a- Common pain conditions across the lifespan a- Biobehavioral mechanisms of chronic pain a- Pharmaceutical, neurological, and rehabilitative interventions a- Psychosocial, complementary/alternative, narrative, and spiritual approaches a- Ethical issue and future directions With the rise of integrative perspective and the emphasis on overall quality of life rather than discrete symptoms, pain management is gaining importance across medical disciplines. Handbook of Pain and Palliative Care stands out as a one-stop reference for a range of professionals, including health practitioners specializing in pain management or palliative care, clinical and health psychologists, public health professionals, and clinicians and administrators in long-term care and hospice.

Il volume descrive il rivoluzionario "metodo Gorter", un approccio integrativo e non tossico alla cura del cancro a cui ogni giorno si affida un numero sempre maggiore di pazienti. Basato su lunghi anni di ricerche e sperimentazioni cliniche, il metodo punta a rafforzare il sistema immunitario attraverso la terapia della febbre (ipertermia), l'inoculazione di cellule dendritiche, l'uso del vischio (viscum album) e di integratori alimentari, oltre che tramite cambiamenti decisivi nella dieta e nello stile di vita. Organizzato in tre parti, il libro offre una panoramica dettagliata del trattamento, illustrando le ricerche che hanno portato al suo sviluppo e delineando le principali strategie per rafforzare la risposta immunitaria. Sono riportate inoltre diverse testimonianze di pazienti, molti dei quali sono sopravvissuti ben oltre la propria prognosi, ottenendo in alcuni casi una remissione completa e duratura della malattia. Il libro si rivolge sia ai medici che al largo pubblico.