Endocrinologia e metabolismo

Many foot problems in diabetes can be prevented and often the patients are misdiagnosed, or inappropriately referred or treated. This title will be of immense use to the audience as work of reference. Diabetes mellitus is the lack of insulin leading to uncontrolled carbohydrate metabolism, the breakdown of starches and sugars into smaller units that can be used by the body for energy. Foot ulcers occur in about 15 per cent of diabetic patients in their lifetime and hospital admissions due to foot ulcers are very common. Foot problems mostly occur when there is nerve damage in the feet or when there is poor blood flow. It contains colour photos and pictures. There are examples for identification of the patients at risk for foot ulceration. It also includes prompt diagnosis and treatment.

Diabetes mellitus, particularly non-insulin-dependent diabetes Type 2, is a common disease and, even though insulin has been around for seventy years, this endocrine disorder still reduces the life expectancy of diabetic patients because of the development of long-term complications, including hypertension. Hypertension occurs twice as often in diabetic patients as in non-diabetic ones. The combination of diabetes and hypertension creates a greater risk of coronary artery disease which is the major cause of death in westernized societies. Bryan Williams and his international team of collaborators provide the reader with their views for treatment of diabetes associated with hypertension and the prevention of subsequent coronary artery disease and other disorders.

L'obesità è ormai diventata la malattia più frequente nelle società del benessere e le complicazioni a essa connesse sono a loro volta la più frequente cause di morte in Occidente. Questo libro vuole trasferire i dati della più recente ricerca medico-biologica in tema di obesità a quegli psicologi clinici, a quei medici e a quegli educatori che hanno un contatto diretto con i singoli pazienti obesi: questo potrà contribuire alla integrazione culturale indispensabile per la gestione clinica della malattia obesità. I concetti esposti serviranno a sfatare tutti quei pregiudizi e tutte quelle false credenze che nella società occidentale tanto influiscono sulle condizioni psicologiche e la qualità di vita di ogni paziente.

Volume di 520 pagine con numerose illustrazioni e tabelle. Rilegato con copertina stampata a colori e plastificata.Questo testo fornisce una revisione esaustiva ed aggiornata di tutti gli aspetti clinici della malattia cardiovascolare nei diabetici, approfondendo i rapporti tra diabete, aterosclerosi, mascro e miscroangiopatia, e le conseguenze cliniche a livello di cuore, rene, occhio e cervello. Nel testo vengono inoltre approfonditi gli aspetti patogenetici del danno vascolare nel diabetico. Il diabete rappresenta, infatti, una malattia di crescente rilevanza socio-sanitaria, sia per la sua elevata prevalenza che per le complicanze a lungo termine che lo caratterizzano. Tale affermazione risulta ancora più rilevante se rapportata al progressivo invecchiamento della popolazione, in termini di invalidità di comorbidità soprattutto per le complicanze cardiovascolari, nervose, renali ed oculari. In questo testo gli autori affrontano la patologia diabetica in rapporto ai meccanismi patogenetici ed ai fattori di rischio (ipertensione, dislipidemia, trombofilia), fornendo i dati più aggiornati sull’epidemiologia, l’eziopatogenesi, la valutazione diagnostica e la terapia della micro e macroangiopatia. Vengono esaminate in dettaglio la retinopatia, la nefropatia, la neuropatia e la microangiopatia diabetica. I capitoli sono estremamente dettagliati ed esaustivi, e corredati di numerose ed aggiornate voci bibliografiche. Il testo “Diabete e malattie cardiovascolari” fornisce pertanto ai medici in formazione, ai medici generici ed agli specialisti le più aggiornate conoscenze necessarie per la piena comprensione della malattia diabetica e per l’adozione della terapia più aggiornata e razionale del singolo paziente. Il testo è suddiviso in 4 sezioni. Nella prima, che tratta la fisiopatologia della malattia diabetica, sono illustrati le caratteristiche della sindrome plurimetabolica, l’effetto dell’insulina sul sistema cardiovascolare, l’effetto del diabete sulle funzioni endoteliali, le alterazioni vascolari tipiche dello stato prediabetico, il meccanismo del danno dei prodotti terminali della glicosilazione, i rapporti tra diabete e sistema renina-angiotensina, diabete e complicanze vascolai, diabete e rispettivamente fibrinolisi, produzione di ossido nitrico, ipertensione, dislipidemia, trombosi, aterosclerosi. Questa sezione contiene inoltre un capitolo sui modelli animali. La seconda sezione è dedicata al cuore, ed in particolare alla cardiopatia ischemica, allo scompenso cardiaco ed alla gestione pre e post-operatoria dei pazienti diabetici. La terza sezione illustra i rapporti fra diabete e circolazione periferica, a livello di epidemiologia, diagnosi e terapia. La quarta sezione, infine, affronta il rapporto tra diabete e microangiopatia, a livello del letto vascolare renale, oculare e nervoso. L’ultimo capitolo tratta esaustivamente del piede diabetico. Il testo è corredato da un completo indice analitico e da illustrazioni e tabelle chiare ed esaurienti.

Obesity is a chronic, stigmatized disease that is increasing in prevalance. Therapeutic options are limited in their effectiveness and frustration often leads to the discontinuation of any therapy. An Atlas of Obesity and Weight Control is a clearly written, beautifully illustrated color atlas on obesity, including its etiology, development and treatment. The book contains nearly 150 clinical pictures of obesity and its related conditions, as well as many pertinent clinical guidelines and up-to-the-minute data on assessment and treatment. The main chapters cover assessment and prevalence, how obesity develops and how it becomes a health hazard, classification and clinical types of obesity, evaluation and introduction to treatment, behavior modification, diet, exercise, drug treatment and surgical treatment and provide a timely and much-needed overview of current knowledge and practice in the treatment of obesity. The volume concludes with bibliographic references and an index. Nutritionists, internists, bariatric physicians, dieticians, endocrinologists, and medical and academic professionals will find An Atlas of Obesity and Weight Control is an essential reference.

In mammals, a robust physiologic system acts to maintain relative constancy of weight. A key element of this system is leptin. The nature of this "brain-somatic" cross talk is as yet poorly understood, but it is likely to have important implications for the pathophysiology and treatment of obesity, diabetes and other metabolic disorders.

In the past five years, so much additional progress has been made in ourunderstanding of both the basic and c1inical aspects of a wide variety of thyroid disorders that a second edition of Diseases of the Thyroid was considered a necessary addition to the Contem- porary Endocrinology series. Fresh perspectives also seemed warranted, so we recruited new authors for many of the chapters and believe that this edition will provide the reader with further insights into the pathophysiology and c1inical presentation and treatment of thyroid disease. It inc1udes topics ranging from neonatal thyroid screening, thyroid dysfunction during infancy and childhood, peripartum thyroid disorders, thyroid disease in the elderly, and the c1inical relevance of the sodiurnliodide symporter (NIS) to the pathogenesis and treatment of nodular goiter, thyroid cancer, thyrotoxicosis, and hypothyroidism. The worldwide problem of iodine deficiency and its eradication is also discussed, along with environmental goitrogens and iodine-induced thyroid disease. I am indebted to all the contributors for their cooperation and expertise in providing their chapters in an extremely timely fashion, to Mr. Thomas Moore and Mr. Craig Adams from Humana Press for their expert assistance, and to Ms. Christine Archung for providing superb administrative assistance. Lewis E. Braverman, MD v CONTENTS Preface ...v Contributors ...ix Molecular Mechanisms of Nuclear Thyroid Hormone Action William W. Chin and Paul M. Yen ...1 2 Nongenomic Actions of Thyroid Hormone Paul 1. Davis and F aith B. Davis ...19 3 Thyroid Testing: A Clinical Approach Laurie A. Kane and Hossein Gharib ...

'Textbook of Diabetes is an extremely well organized, superbly edited, richly illustrated two-volume set from Britain...The chapters have logical beginnings and endings and are self-contained. Each begins with a summary of the chapter contents - a true s

This comprehensive reference covers the latest developments and information on the scientific and clinical bases of the management of diabetes and its complications. Edited by leading national authorities, this text contains an appropriate balance of coverage between scientific and clinical considerations, supplying readers with state-of-the-art approaches to the management of diabetes. Thoroughly revised, the sixth edition of this classic text includes updated chapters on new drugs in development, diabetes self-management, and intensive therapy of diabetes mellitus, which is the preferred approach to managing the diabetic patient.

Featuring more than 530 vivid illustrations, clinical photographs, and instructive diagrams and charts - all with detailed legends - this new atlas provides a comprehensive visual exposition of all aspects of diabetes. More than 20 outstanding contributors present state-of-the-art information and expert perspectives on pathogenesis, prevention, management, complications, and the newest treatment options available. This edition includes brand-new chapters on diabetes during pregnancy and childhood diabetes and up-to-date perspectives on management and prevention of complications in type 1 diabetes, mechanisms of insulin action, pathogenesis of type 2 diabetes, obesity, and diabetic neuropathies

This volume outlines what is meant by terms such as 'evidence based practice', 'systematic review', 'efficacy', 'effectiveness'. It summarises, in a systematic fashion, the current evidence on diabetes prevention and care to enable the reader to improve their professional practice. Furthermore, it promotes a critical attitude to the assessment of evidence and engenders enthusiasm for 'lifelong learning'. It also advises clinicians on what to do when there is little available evidence. Chapters consider the evidence base for the definition and classification of diabetes, as well as prevention, identification, treatment, education in IDDM and NIDDM. The final chapters look at the practical implications of translating this evidence into practice in different environments with different health care systems and different economic levels. * This is the first book to present an evidence-based approach to diabetes * Examines the evidence base for the definition and classification of diabetes, as well as prevention, iden tification, treatment, and education in IDDM and NIDDM * Looks at the practical implications of translating this evidence into practice in different environments * The editors are leaders in the move towards evidence-based diabetes care

"Comprehensive Clinical Endocrinology, 3/e" is the new, fully revised edition of the successful book on "Clinical Endocrinology, 2/e", published in 1994, expanded to cover diabetes in great detail. With greatly increased clinical detail on each condition and new clinical treatment plans to assist in the long-term treatment of patients, this book will contain all you need to know about every endocrine condition. Full colour throughout will make "Comprehensive Clinical Endocrinology" an attractive book, and the completely re-drawn line illustrations will enhance the detailed text.

Physiologic adaptations and pathologic states that result from changes of target tissue sensitivity to hormones are vital concerns in endocrinology. Part of the "Modern Endocrinology Series", this text features an overview of the human hormone resistance and hypersensitivity syndromes due to pre-receptor, receptor and postreceptor abnormalities. Focuses on the pivotal study of the etiology of common conditions, such as obesity and essential hypertension, in chapters written by experts who have performed primary research in hormone action. This is a Brandon-Hill recommended title.

The Second Edition of this comprehensive reference combines a strong scientific base with a clinical focus to address the principal disorders of bone and mineral metabolism, including osteoporosis, kidney stone formation, abnormal serum mineral levels, Paget's disease, and other conditions. The contributors examine normal bone structure and mineral metabolism throughout the life cycle, explain the mechanisms underlying each disorder, and provide succinct guidance on evaluation and management. This edition describes recently introduced drugs, thoroughly reviews powerful new treatments for osteoporosis and nephrolithiasis and also features completely rewritten chapters on stone formation. Over than 500 illustrations complement the text plus over 150 tables help readers find needed information at a glance

Basic immunological principles and methods as they relate to cellular and subcellular processes of the endocrine system are important in understanding the underlying causes of endocrine disorders. Part of the Modern Endocrinology Series , this text covers a wide array of topics including pancreas development, immunogenetics, hypoparathyroidism, Graves' disease and vitiligo. The book is an integrated resource with a bench-to-bedside breadth that is useful to both basic scientists and healthcare professionals interested in endocrine autoimmune diseases

In this title, an extensive body of evidence highlights the crucial importance of endocrine genetics. Examples range from human growth disorders and obesity to cancers of the prostate and breast. A pivotal part of the "Modern Endocrinology Series", this book presents major biological studies underlining the significance of data obtained from knock-out mice, as well as from transgenic animals. Gene therapy and laboratory evaluation and screening of genetic endocrine diseases are covered, as are many of the classical endocrine diseases.