Biologia molecolare dei tumori
Tutti i libri di Biologia molecolare dei tumori - Pagina 2
Beyond Apoptosis
Cellular Outcomes of Cancer Therapy
Dale E. Bredesen
,
Igor B. Roninson
e altri
editore: Informa Healthcare
pagine: 376
Addressing a major field of interest for oncologists, cell biologists, and other biomedical researchers, Beyond Apoptosis provides an overview of how different biological mechanisms of cell death, senescence and mitotic catastrophe stop the growth of tumor cells treated with anticancer agents. Written by internationally renowned contributors, this text includes: morphological illustrations, as well as a DVD containing documents and video clips from various time-lapse microscopic studies of cell death and mitotic catastrophe the role and limitations of apoptosis as a determinant of the toxicity of anticancer agents alternative mechanisms of the antiproliferative actions of anticancer drugs and radiation, such as non-apoptotic cell death, cell senescence, and mitotic catastrophe non-apoptotic forms of cell death, such as necrosis, paraptosis, autophagic cell death, and others morphological and kinetic differences of the various forms of cell death
Interventional Oncology
Principles and Practice
J. F. Geschwind , Michael C. Soulen
editore: Cambridge
pagine: 636
Interventional oncology has joined surgical, radiation, and medical oncology as the fourth pillar of cancer care. Advances in imaging and image guidance for the detection, characterization, targeting, and therapy of cancer now allow for minimally invasive image-guided treatment of many solid tumors without the morbidity of open surgery or the toxicity of chemotherapy and radiation. The editors have brought together the accrued experience of pioneers and leaders in image-guided cancer therapy from around the globe to create the first comprehensive text for this emerging field. Covering the biology, techniques, clinical applications, and outcomes of interventional oncologic procedures for the treatment and palliation of solid tumors throughout the body, this practical reference will be indispensable for physicians across specialties who seek to provide collaborative, leading-edge care to cancer patients.
Molecular Targeting in Oncology
Howard L. Kaufman
,
Karen Antman
e altri
editore: Humana Press Inc.
pagine: 744
This book presents an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer. It is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.
Cancer Biomarkers
Analytical Techniques for Discovery
Mahmoud H. Hamdan
editore: Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)
pagine: 378
Tools, techniques, and progress in cancer biomarkers discovery The completion of a number of gene sequencing projects, recent advances in genomic and proteomic technologies, and the availability of powerful bioinformatics tools have led to promising new avenues and approaches in the search for cancer biomarkers. This book provides a comprehensive overview of current methodologies and technologies. It discusses biomarker discovery as a whole, rather than focusing on one specific marker or cancer.
With information on both existing and potential biomarkers, Cancer Biomarkers: Analytical Techniques for Discovery: Provides insights into the current technological platforms for biomarker discovery, including mass spectrometry combined with multidimensional chromatography, DIGE, and various chip technologies Includes a detailed discussion of protein networks and protein phosphorylation in cancer Details the use of imaging mass spectrometry, laser capture microdissection, serial analysis of gene expression, enzyme-linked immunosorbent assays, protein microarrays, antibody-based microarrays, and bioinformatics Covers the emerging role of surface-enhanced laser desorption ionization (SELDI) and various tagging and labeling strategies Discusses related regulatory and ethical issues With a wealth of information that can be applied to a broad spectrum of biomarker research projects, this is a core reference for biomarker researchers, scientists working in proteomics and bioinformatics, pharmaceutical scientists, oncologists, biochemists, biologists, and chemists.
Cancer Diagnosis in Primary Care
Tim J. Peters , William Hamilton
editore: Churchill Livingstone
pagine: 208
The aim of the book is to inform primary care clinicians (including those in training) about the way cancer presents to primary care, and how they can select patients for investigation. One quarter of UK deaths are from cancer, and the large majority of these tumours initially present to primary care. Cancer diagnosis is difficult, both in identifying those who do need investigation, and those who don't. "Cancer Diagnosis in Primary Care" covers the major cancers in individual chapters. The book also includes chapters on screening, systemic symptoms (which may be present with a number of cancers), and the terms used in cancer epidemiology. A final section of 'case-studies' offers an important opportunity for teaching or self-assessment. Although based on a thorough knowledge of the subject, the book uses an ex-cathedra style rather than being peppered with references in a highly academic fashion. The facts are right, but the aim is to make it readable! The approach is firmly based on the primary care clinician's needs. The editors are academics in primary care, who are active researchers in the cancer field, and have a heavy involvement with the national cancer scene.
Cancer Grading Manual
Fang Fan , Ivan Damjanov
editore: Springer Verlag New York Inc.
pagine: 136
This book addresses all histopathologic aspects of tumor pathology essential for grading of tumors. It discusses the history and basic tenets of tumor grading; principles of microscopic grading of tumors; ancillary methods currently used to improve tumor grading; and new techniques used in evaluating tumors and formulating prognosis. It is designed to be a practice-oriented, concise and well-illustrated resource for diagnostic surgical pathologists and pathology residents. The manual is organized by specific organ systems. Each chapter begins with an introduction and describes in detail the optimal and most widely used system for grading common tumors.
A Practical Guide to Human Cancer Genetics
Charis Eng
,
Eamonn R. Maher
e altri
editore: Cambridge
pagine: 410
The 2006 third edition of this very successful book provides a comprehensive and practical guide to the diagnosis and management of inherited disorders conferring susceptibility to cancer. Issues discussed include risk assessment, genetic counselling, predictive testing and organisation of a cancer genetics service. A full reference list gives access to background literature. With molecular information, screening guidelines and management advice, this new edition will provide geneticists and clinicians in all disciplines with an invaluable resource for screening, managing and advising patients.
Oncology and Basic Science
Carol D. Morris
,
Paul Tornetta
e altri
editore: Lippincott Williams and Wilkins
pagine: 576
This volume of our "Orthopaedic Surgery Essentials Series" presents all the information residents need during orthopaedic oncology rotations and the essential basic science needed for board preparation, clinical practice, and orthopaedic research, including molecular and cellular biology, growth and development, the genetic basis of musculoskeletal disorders, biomaterials and biologic response to orthopaedic implants, and neoplastic disorders. The book can easily be read cover to cover during a rotation or used for rapid review before boards or quick reference in clinical practice. The user-friendly, visually stimulating format features numerous tables and ample illustrations, including color plates showing tumor histopathology.
Tumori e geni
Conoscenze e indirizzi comportamentali in Oncogenetica clinica
Scopsi, L. , Gualandri, V.
editore: Verduci
pagine: 256
Terapia molecolare in oncologia
a cura di D. Amadori , C. M. Croce
editore: Poletto Editore
pagine: 440
Il termine terapia molecolare mirata è usato per riferirsi ad agenti che colpiscono i percorsi specifici attivati nei processi
Tumor Diagnosis
Practical Approach and Pattern Analysis
Awatif I. Al-Nafussi
editore: Hodder Arnold
pagine: 1344
Tumor Diagnosis - Practical approach and pattern analysis, Second edition, has been thoroughly revised to provide the most up-to-date information for all pathologists, histopathologists and trainee pathologists working in the diagnosis of tumors and tumor-like conditions. Following the success of its predecessor, this will once again prove the most valuable bench guide available. Every subject has been reconsidered and refined. The original parts have been retained: the first giving details of the patterns to be found, and what they indicate; the second categorizing tumors under organ systems rather than listing them all together and designed to be referred to during practical laboratory work.
Molecular Biology of Human Cancers
An Advanced Student's Textbook
Wolfgang Arthur Schulz
editore: Springer Verlag New York Inc.
pagine: 527
Cancer research is now an interdisciplinary effort requiring a basic knowledge of commonly used terms, facts, issues, and concepts. This interdisciplinary book meets this need, providing an authoritative overview to the field. It presents many of the molecules and mechanisms generally important in human cancers and examines a broad, but exemplary, selection of cancers. In addition, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. This book summarizes the state, pitfalls, and potential of these efforts.
Tumor Immunology and Cancer Vaccines
editore: Springer Verlag New York Inc.
pagine: 408
"Tumor Immunology and Cancer Vaccines" addresses the state of the art knowledge of tumor immunology relevant to cancer vaccine and the different aspects of cancer vaccine development, covering the field from its basic science logic to clinical trials. The four sections of the book, Basic Tumor Immunology; Cancer Vaccine Development; Vaccine-Enhancing Strategies; and Clinical Trials Design, provide a general overview of the field, historic background, and the field's promises and problems.
Molecular Biology of Cancer - Advanced Text
-
Macdonald, F. , Ford, C. H. J. , Casson, A. G.
editore: Bios
pagine: 270
Culture of Human Tumor Cells
R. Ian Freshney , Roswitha Pfragner
editore: John Wiley & Sons Inc
pagine: 452
This comprehensive resource provides stepwise protocols for the in vitro cultivation of the major types of human tumors. Written in a reader-friendly style, this book is organized by specific tumor, discussing cultures for lung, gastric, colorectal, pancreas, bladder, prostate, ovary, cervix, mammary carcinoma, myoepithelium, squamous, melanoma, lymphoma, glioma, and neuroendocrine tumors. Detailed techniques for initiation, propagation, and characterization of established cell lines are presented. Drug treatment, selection, differentiation, assays for malignant cells, risks, and applications are discussed. An extensive listing of vendors for equipment and other cell culture products is also included.
Principles of Molecular Oncology
Giuseppe Giaccone
,
Maryann Foote
e altri
editore: Humana Press Inc.
pagine: 736
World reknown basic scientists and clinical researchers update the wealth of new molecular knowledge that sees cancer as a 'disease process' involving key regulatory pathways. Emphasizing prevention, early diagnosis, prognosis, and treatment, these authoritative experts from around the world illuminate the variety of molecular markers to be found, interpret what is known about diseased regulatory pathways, and examine those future research directions likely to realize the promise of molecular therapy. From their presentations, readers will gain an understanding of the new processes now available to identify specific molecular targets for optimal therapeutic efficacy. Comprehensive and path-breaking, "Principles of Molecular Oncology, Second Edition" offers both basic and clinical oncologists not only a bold synthesis of the rapid and complex advances in molecular biology that are transforming our knowledge of cancer, but also a highly practical guide to today's strategies for its diagnosis and treatment.
Cancer Immunotherapy at the Crossroads
How Tumors Evade Immunity and What Can be Done
James H. Finke , Ronald M. Bukowski
editore: Humana Press Inc.
pagine: 403
Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human tumors, focusing on tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), that may serve as biomarkers for patient prognosis. They discuss the means by which these immune functions may be protected or restored in order to more effectively support the process of tumor rejection in situ. Cutting-edge techniques are outlined with the capacity to monitor the strength and quality of patients' immune responses using immunocytometry, MHC-peptide tetramers combined with apoptosis assay, ELISPOT assay, and detection of MHC-TAA peptide complexes on tumor cells.
Cancer Cell Culture
Methods and Protocols
S. Langdon
editore: Humana Press Inc.
pagine: 376
Expert researchers describe in detail their most productive and up-to-date methods for growing cancer cells in the laboratory. There are methods to characterize and authenticate cell lines, to isolate and develop specific types of cancer cells, and to develop new cell line models. Functional assays are provided to evaluate clonogenicity, cell proliferation, apoptosis, adhesion, migration, invasion, senescence, angiogenesis, and cell cycle parameters. Other methods permit the modification of cancer cells for transfection, development of drug resistance, immortalization, and transfer in vivo; the co-culture of different cell types; and the detection and treatment of contamination.
Management of Infection in Oncology Patients
John R. Wingard , Raleigh A. Bowden
editore: Taylor & Francis Ltd
pagine: 450
This text presents a comprehensive review of the range of infectious complications that can arise in oncology patients as a result of their underlying malignancy, as well as from their treatment. The first section considers the effects of different treatment strategies on various host defenses. The second section describes the various infectious syndromes and addresses types of pathogens, shifts over time and changing diagnostic considerations. The final section discusses adjunctive measures that can prevent and assist antimicrobial agents in infection control. The book offers practical advice for practicing oncologists, hematologists and infectious disease specialists.
Hormones, Genes and Cancer
B. A. J. Ponder
,
Brian E. Henderson
e altri
editore: Oxford University Press Inc
pagine: 464
Hormonal carcinogenesis is an important and controversial area of research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? And how do genetic factors influence hormone-related cancer risk? This work addresses these questions. During the last few decades of the 20th century, cancer research focused on external environmental causes (for example, tobacco smoke, viruses, asbestos). With the advent of genetic sequencing techniques, we are just now beginning to understand how the body's internal environment (that is, the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise.
