Springer

This book explains clearly and in detail all aspects of radiation protection in nuclear medicine, including measurement quantities and units, detectors and dosimeters, and radiation biology. Discussion of radiation doses to patients and to embryos, fetuses, and children forms a central part of the book. Phantom models, biokinetic models, calculations, and software solutions are all considered, and a further chapter is devoted to quality assurance and reference levels. Occupational exposure also receives detailed attention. Exposure resulting from the production, labeling, and injection of radiopharmaceuticals and from contact with patients is discussed and shielding calculations are explained. The book closes by considering exposure of the public and summarizing the "rules of thumb" for radiation protection in nuclear medicine. This is an ideal textbook for students and a ready source of useful information for nuclear medicine specialists and medical physics experts.

"Advanced students and professionals are snapping up this paperback text on linear and quasilinear partial differential equations. Whether you use their book as textbook or reference, the authors give you plenty to think about and work on, including an epilogue summarizing the latest research." --Amazon.com delivers Mathematics and Statistics e-bulletin, July 2001 L'autore Biography of David Gilbarg David Gilbarg was born in New York in 1918, and was educated there through udergraduate school. He received his Ph.D. degree at Indiana University in 1941. His work in fluid dynamics during the war years motivated much of his later research on flows with free boundaries. He was on the Mathematics faculty at Indiana University from 1946 to 1957 and at Stanford University from 1957 on. His principal interests and contributions have been in mathematical fluid dynamics and the theory of elliptic partial differential equations. Biography of Neil S. Trudinger Neil S. Trudinger was born in Ballarat, Australia in 1942. After schooling and undergraduate education in Australia, he completed his PhD at Stanford University, USA in 1966. He has been a Professor of Mathematics at the Australian National University, Canberra since 1973. His research contributions, while largely focussed on non-linear elliptic partial differential equations, have also spread into geometry, functional analysis and computational mathematics. Among honours received are Fellowships of the Australian Academy of Science and of the Royal Society of London.

To the Teacher. This book is designed to introduce a student to some of the important ideas of algebraic topology by emphasizing the re­ lations of these ideas with other areas of mathematics. Rather than choosing one point of view of modem topology (homotopy theory, simplicial complexes, singular theory, axiomatic homology, differ­ ential topology, etc.), we concentrate our attention on concrete prob­ lems in low dimensions, introducing only as much algebraic machin­ ery as necessary for the problems we meet. This makes it possible to see a wider variety of important features of the subject than is usual in a beginning text. The book is designed for students of mathematics or science who are not aiming to become practicing algebraic topol­ ogists-without, we hope, discouraging budding topologists. We also feel that this approach is in better harmony with the historical devel­ opment of the subject. What would we like a student to know after a first course in to­ pology (assuming we reject the answer: half of what one would like the student to know after a second course in topology)? Our answers to this have guided the choice of material, which includes: under­ standing the relation between homology and integration, first on plane domains, later on Riemann surfaces and in higher dimensions; wind­ ing numbers and degrees of mappings, fixed-point theorems; appli­ cations such as the Jordan curve theorem, invariance of domain; in­ dices of vector fields and Euler characteristics; fundamental groups

There is an increasing need for medical thoracoscopy performed by pulmonologists, which may be video assisted and has the advantage of being very cost-effective. This book is a comprehensive and up-to-date guide to thoracoscopy for pulmonologists that documents the considerable progress in endoscopic telescopes and instrumentation. Clear practical guidance is provided on technique, and diagnostic, therapeutic, and interventional applications of thoracoscopy are all carefully examined with the aid of high-quality illustrations. Although medical thoracoscopy is much less invasive than thoracotomy, complications can occur in a small number of cases; these are discussed and advice on prevention is provided. The concluding section examines the future of the field, covering developments such as ‘mini’ thoracoscopy, autofluorescence thoracoscopy, and flexi-rigid thoracoscopy.

This book contains all of Leonardo Da Vinci's drawings on the heart and its physiology, accompanied by re-translations of all of the associated notes. All Leonardo's drawings have been interpreted in the light of modern knowledge by a practicing cardiac clinician and anatomist. The veracity of his work is proven against contemporary dissections of cardiac structure and comparison of his illustrations with contemporary images generated by Magnetic Resonance scanners and high definition ultrasound will astound the reader. Perhaps the most interesting element is the re-dissection of the Ox heart set against Leonardo’s own drawings. His place in the greater scheme of anatomical development will be put into context with his ideas of man’s place in the microcosm/macrocosm continuum.

Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.

Thanks to the omnipresent computer, current statistics can include data files of many thousands of values, and can perform any exploratory analysis in less than seconds. This development, however fascinating, generally does not lead to simple results. We should not forget that clinical studies are, mostly, for confirming prior hypotheses based on sound arguments, and the simplest tests provide the best power and are adequate for such studies. In the past few years the authors of this 5th edition, as teachers and research supervisors in academic and top-clinical facilities, have been able to closely observe the latest developments in the field of clinical data analysis, and they have been able to assess their performance. In this 5th edition the 47 chapters of the previous edition have been maintained and upgraded according to the current state of the art, and 20 novel chapters have been added after strict selection of the most valuable and promising novel methods. The novel methods are explained using practical examples and step-by-step analyses readily accessible for non-mathematicians. All of the novel chapters have been internationally published by the authors in peer-reviewed journal, including the American Journal of Therapeutics, the European Journal of Clinical Investigation, The International journal of Clinical Pharmacology and therapeutics, and other journals, and permission is granted by all of them to use this material in the current book. We should add that the authors are well-qualified in their fields of knowledge. Professor Zwinderman is president-elect of the International Society of Biostatistics, and Professor Cleophas is past-president of the American College of Angiology. From their expertise they should be able to make adequate selections of modern methods for clinical data analysis for the benefit of physicians, students, and investigators. The authors, although from a different discipline, one clinician and one statistician, have been working and publishing together for over 10 years, and their research of statistical methodology can be characterized as a continued effort to demonstrate that statistics is not mathematics but rather a discipline at the interface of biology and mathematics. They firmly believe that any reader can benefit from this clinical approach to statistical data analysis.