Mitochondria, often referred to as the "powerhouses" of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.
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Chapter 1 Role of Mitochondrial Reactive Oxygen and Nitrogen Species in Respiratory Diseases Harijith Anantha, Prasad Kanteti, Panfeng Fu, Sainath R. Kotha, Narasimham L. Parinandi, and Viswanathan Natarajan Chapter 2Regulation of Mitochondrial Functions by Transcription Factor NRF2 Narsa Machireddy, Wajiha Qureshi, Haranath Potteti, Dhananjaya V. Kalvakolanu, and Sekhar P. Reddy Chapter 3 Mitochondrion: A Missing Link in Asthma Pathogenesis Ulaganathan Mabalirajan, Anurag Agrawal, and Balaram Ghosh Chapter 4 ROS Signaling in Cardiovascular Dysfunction Associated with Obstructive Sleep Apnea Ganesh K. Kumar, Gayatri Raghuraman, and Nanduri R. Prabhakar Chapter 5 Mitochondrial Excitation-Energy Coupling in Airway Smooth Muscle Niccole Schaible, Philippe Delmotte, and Gary C. Sieck Chapter 6 Mitochondrial Lipid Peroxidation in Lung Damage and Disease Sainath R. Kotha, Travis O. Gurney, Miles U. Magalang, Thomas J. Hund, Abhay R. Satoskar, Peter J. Mohler, Krishna Rao Maddipati, Viswanathan Natarajan, and Narasimham L. Parinandi Chapter 7 The Impact of DNA Damage on Epithelial Cell Maintenance of the Lung Lidza Kalifa and Michael A. O'Reilly Chapter 8 Mitochondrial Function in Lung Health and Disease Luis Puente-Maestu and Jorge Chancafe-Morgan Chapter 9Age-Specific Difference in Pulmonary Cellular Injury and Mitochondrial DamageKatherine L. Tuggle and Michelle V. Fanucchi
