This book is dedicated to our readers with the intention of providing an informative exposition of the myositis syndromes. It is also presented in the hope that perhaps it may serve to inspire and stimulate discussion and research into these disabling disorders. Included are descriptions of clinical features, differential diagnosis, pathogenetic mechanisms, and approaches to therapy. Current concepts of classi- cation and diagnostic techniques are also presented. The production staff at Humana Springer, especially Ms. F. Louie and Ms. C. Walsh, have been instrumental and invaluable in allowing this work to see the light of day. Above all, the scholarly essays of the contributing authors are acknowledged with gratitude. They have given this volume its character and existence. New York, NY Lawrence J. Kagen v Contents Preface ...v Contributors ...ix 1 Evaluation of the Patient ...1 Lawrence J. Kagen 2 Classification of Idiopathic Inflammatory Myopathies ...15 Frederick W. Miller 3 The Inflammatory Milieu: Cells and Cytokines...29 Ann M. Reed and Thomas A. Griffin 4 Juvenile Dermatomyositis: An Update on Clinical and Laboratory Findings ...55 Lauren M.
Pachman 5 Inclusion Body Myositis ...87 Lawrence J. Kagen 6 The Role of Muscle Biopsy in the Diagnosis of Inflammatory Myopathy ...95 Sakir Humayun Gultekin 7 Electromyography ...1 1 1 Hans L. Carlson 8 Magnetic Resonance Imaging of Myopathies and Myositis ...127 Carolyn M. Sofka 9 Ultrasound in the Evaluation of the Inflammatory Myopathies ...147 Ronald S. Adler and Giovanna Garofalo vii viii Contents 10 Serological Findings ...165 Ira N.
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Chapter 1 Evaluation of the Patient Lawrence J. Kagen Chapter 2 Classification of Idiopathic Inflammatory Myopathies Frederick W. Miller Chapter 3 The Inflammatory Milieu: Cells and Cytokines Ann M. Reed and Thomas A. Griffin Chapter 4 Juvenile Dermatomyositis: An Update on Clinical and Laboratory Findings Lauren M. Pachman Chapter 5 Inclusion Body Myositis Lawrence J. Kagen Chapter 6 The Role of Muscle Biopsy in the Diagnosis of Inflammatory Myopathy Sakir Humayun Gultekin Chapter 7 Electromyography Hans L. Carlson Chapter 8 Magnetic Resonance Imaging of Myopathies and Myositis Carolyn M. Sofka Chapter 9 Ultrasound in the Evaluation of the Inflammatory Myopathies Ronald S. Adler and Giovanna Garofalo Chapter 10 Serological Findings Ira N. Targoff Chapter 11 Antisynthetase Syndrome Galina S. Marder and Robert Greenwald Chapter 12 Pulmonary Manifestations of Inflammatory Myopathy Eun Ha Kang and Yeong Wook Song Chapter 13 Dermatological Manifestations of Dermatomyositis Mark Kagen Chapter 14 The Differential Diagnosis of Inflammatory Myopathy Michael Rubin and Asaf Klein Chapter 15 Outcomes and Assessment for Inflammatory Muscle Disease Lisa G. Rider Chapter 16 Muscle Strength and Exercise in Patients with Inflammatory Myopathies Helene Alexanderson and Ingrid E. Lundberg Chapter 17 The Risk of Malignancy in Patients with Dermatomyositis and Polymyositis Alan N. Baer and Robert L. Wortmann Chapter 18 Treatment Stephen J. DiMartino
