Diabetes and the Kidney provides endocrinologists andnephrologists of all levels with expert clinical diagnosis andmanagement guidance for this extremely common diabeticcomplication.Practical and accessible, chapters contain textfeatures such as case histories, potential pitfall boxes, keypoints, management algorithms, and useful weblinks to fullyengage the reader and provide expert guidance to help cliniciansbest manage their patients. In addition, allrelevant international society guidelines and recommendationsare fully included.After an initial analysis of the epidemiology andpathogenesis of kidney complications in diabetes, it quickly moveson to the following core sections: - Special Situations, Risk factors and Complications- examining diabetic nephropathy in relation to each other diabeticcomplication, ie cardiovascular disease- Prevention and Therapy - focusing on the most up todate information regarding prevention, diagnosis, treatment, andmanagement of kidney disease in diabetes.Expertly edited, and with contributions from an experiencedinternational team, Diabetes and Kidney Disease will be theperfect tool to consult when managing diabetic patients withassociated kidney problems.
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Contributors, vii Preface, x Part I Introduction and Pathophysiology 1 History of diabetic nephropathy: a personal account, 3 Eberhard Ritz 2 Epidemiology of chronic kidney disease in diabetes, 14 Andrea Icks and Michael Koch 3 Genetic risk factors for diabetic nephropathy, 29 Carsten A. Boger and Peter R. Mertens 4 Pathophysiology of diabetic nephropathy, 45 Ivonne Loeffler 5 Histology of human diabetic nephropathy, 62 Kerstin Amann and Christoph Daniel 6 Natural history and diagnosis of diabetic kidney disease, 70 Bethany Karl and Kumar Sharma Part II Special Situations, Risk Factors and Complications 7 Cardiovascular disease in diabetic nephropathy: pathophysiology and treatment, 85 Martin Busch 8 Statin therapy in patients with diabetic nephropathy, 101 Christoph Wanner 9 Diabetes mellitus, bone and kidney, 116 Thomas Neumann and Gabriele Lehmann 10 Diabetes, pregnancy and the kidney, 129 Helmut Kleinwechter and Ute Schafer-Graf 11 Diabetic nephropathy in children, 143 Kai D Nusken and Jorg Dotsch 12 Diabetes, the kidney and retinopathy, 153 Hans-Peter Hammes Part III Prevention and Therapy 13 Reducing progression of diabetic nephropathy by antihyperglycemic treatment, 171 Christoph Hasslacher 14 Dosage of antihyperglycemic drugs in patients with renal insuffi ciency, 186 Alexander Samann and Ulrich A. Muller 15 Reducing progression of diabetic nephropathy by antihypertensive treatment, 202 Anita Hansen, Ivo Quack and Lars Christian Rump 16 Treatment of the patient with end-stage diabetic nephropathy, 215 Muriel Ghosn and Fuad N. Ziyadeh 17 Combined pancreas and kidney transplantation or kidney alone transplantation for patients with diabetic nephropathy, 232 Hermann J. Kissler, Christiane Ruster and Utz Settmacher Index, 253 Color plate section can be found facing page 54
