Instant Clinical Pharmacology differs from other clinical pharmacology books commonly used by medical students and junior doctors. It presents essential information about the core topics in clinical pharmacology in a concise, accessible dip-in format and aims to bridge the gap between basic pharmacology and the therapeutic use of drugs in humans. Each topic is concisely displayed in a double-page spread to aid learning and revision. Content in this revised second edition covers the accepted core curriculum of clinical pharmacology: clinical pharmacokinetics, factors affecting dosing, altered drug effects, pharmacovigilance and principles of optimal therapeutics. Simple illustrations and tables support the text and assist to provide rapid access to and explanation of key facts.
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Introduction. 1: Clinical pharmacokinetics. General Overview: Clinical Pharmacokinetics. Pharmacokinetics. Drug Clearance (CL). Volume of Distribution (Vd). The Half-life (t1/2). Oral Availability (F). Protein Binding (PB). pH and Pharmacokinetics. 2: Factors affecting dosing. Drug Metabolism. Saturable Metabolism. Dosing in Liver Disease and Other Diseases. Pharmacogenetics. Dosing in Renal Impairment. Dosing in the Elderly. Dosing in Neonates/Children. Drugs in Pregnancy. Drugs in Human Milk. 3: Pharmacovigilence. Adverse Drug Reactions (ADRs). Drug-Induced Allergy. Adverse Drug Events (ADEs). Drug/Drug Interactions. Drugs and Food. Drug Concentration Monitoring. Pharmacokinetics and Pharmacodynamics in Overdose. Treatment of Overdose/Poisoning. Pharmacological Aspects of Drug Dependence. 4: Optimal Therapeutics. Pharmacodynamics/Principles of Drug Action. Applied Pharmacology. Drug Delivery Systems. Compliance with Medication. Aids to Prescribing/Compliance. Principles of Therapeutics. Talking with Patients About their Drugs. The Drug Profile. Complementary and Alternative Medicines (CAMs). Evidence-based Medicine (EBM). Pharmacoeconomics. Prescribers and the Drug Industry. Drug Development. 5: Appendices. 1: 'Instant Pharmacokinetics' - the Pharmacokinetic Triangle. 2: Important Equations in Clinical Pharmacology. 3: Drugs with Renal Elimination That May Need Dose Adjustment in. Renal Impairment. 4: High CL Drugs, with Flow Dependent Elimination. 5: Inducers of Drug Metabolism. 6: Inhibitors of Drug Metabolism. 7: Drugs Whose Therapy May be Assisted by Drug Concentration. Monitoring. 8: Essentials of a Good Prescription. 9: Useful Pharmacology Resources. 10: Interactive Clinical Pharmacology. Glossary. Index
