Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and major questions remain as to how dietary/nutritional phytochemical factors biochemically interact with such genetic and epigenetic events. With chapters written by international experts, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention examines the latest developments on the effects of various dietary phytochemicals. Divided into nine sections, the book begins with the basic mechanisms of inflammation/oxidative stress-driven cancer, including an overview of the topic and how to prevent carcinogenesis, the role of obesity in inflammation and cancer, and antioxidant properties of some common dietary phytochemicals.
Subsequent sections cover cellular signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals, as well as their potential challenges with in vivo absorption and pharmacokinetics. The chapters also examine the cancer-preventive properties of various classes of phytochemicals, including vitamins A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, traditional Chinese herbal medicines, and alpha lipoic acid. The final section of the book explores the latest developments on the interactions of dietary phytochemicals through epigenetics and the management of chronic inflammation with nutritional phytochemicals.
Section I: Inflammation, Oxidative Stress, Nutritional Phytochemicals, and Cancer Overview on Oxidative Stress, Inflammation, Cancer Initiation/Progression, and How to Prevent Carcinogenesis/Cancer Jong Hun Lee and Ah-Ng Tony Kong Overview of Obesity, Inflammation, and Cancer Ximena Paredes-Gonzalez, Tin Oo Khor, Limin Shu, Constance Lay-Lay Saw, and Ah-Ng Tony Kong Inflammation-Induced Esophageal and Colon Adenocarcinoma Formation in Animal Models: Mechanisms of Carcinogenesis and Prevention Chung S. Yang, Xiaoxin Chen, and Guang-Yu Yang Overview of Common Dietary Phytochemicals Possessing Antioxidant Properties through Nrf2 Limin Shu, Chengyue Zhang, and Ah-Ng Tony Kong Section II: Signal Transduction, Molecular Targets, and Biomarkers of Dietary Cancer-Preventive Phytochemicals Signal Transduction and Molecular Targets of Dietary Cancer-Preventive Phytochemicals Ann M. Bode and Zigang Dong Biomarkers for Diet in Cancer Prevention Studies Zheng-Yuan Su, Limin Shu, and Ah-Ng Tony Kong Section III: In Vivo Absorption and Pharmacokinetics of Nutritional Phytochemicals Metabolism and Transport of Anticancer and Anti-Inflammatory Phytochemicals across the Gastrointestinal Tract Yong Ma and Ming Hu Pharmacokinetics of Dietary Isothiocyanates and Flavonoids Yoshihiko Ito, Shizuo Yamada, and Marilyn E. Morris Section IV: Vitamins A, D, and E Cancer Prevention, and Clinical Perspective Retinoic Acid Signaling in Hematopoiesis and Immune Functions, and Options for Chemoprevention Rodica P. Bunaciu and Andrew Yen Vitamin D and Inflammation in Cancer: Emerging Concepts Katrina M. Simmons, Wei-Lin W. Wang, Martin P. R. Tenniswood, and JoEllen Welsh Vitamin E Family of Compounds and Cancer Prevention Kimberly Kline, Weiping Yu, Richa Tiwary, and Bob G. Sanders The Protective Role of Vitamin E in Inflammation and Cancer Amanda K. Smolarek and Nanjoo Suh Vitamin D and Cancer: Research Update and Clinical Recommendations Kathleen M. Wesa and Barrie R. Cassileth Section V: Omega-3 and Omega-6 Fatty Acids Plant and Marine Sources of Omega-3 Polyunsaturated Fatty Acids, Inflammation, and Cancer Prevention Julie K. Mason, Ashleigh K. A. Wiggins, and Lilian U. Thompson Polyunsaturated Fatty Acids and Cancer Prevention Janel Suburu and Yong Q. Chen Anti-Inflammatory and Proresolving Effects of Docosahexaenoic Acid: Implications for Its Chemopreventive Potential Young-Joon Surh, Na-Young Song, Ha-Na Lee, and Hye-Kyung Na Section VI: Flavonoids and Polyphenols Green Tea and Cancer Prevention Naghma Khan and Hasan Mukhtar Curcumin from Turmeric Spice, Anti-Inflammatory and Antioxidant Phytochemical, and Cancer Prevention Tin Oo Khor and Ah-Ng Tony Kong Flavonoids: Impact on Prostate Cancer and Breast Cancer James Cardelli, David Coleman, and Katherine D. Crew Cancer Prevention by Isoflavone Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, and Fazlul H. Sarkar Anti-Inflammatory Efficacy of Silibinin: Role in Cancer Chemoprevention Alpna Tyagi, Gagan Deep, and Rajesh Agarwal Cancer Prevention by Antioxidant Compounds from Berries Noah P. Zimmerman, Dan Peiffer, and Gary D. Stoner Section VII: Garlic Organosulfur Compounds and Crucifer Glucusinolates Garlic and Cancer Prevention Chi Chen Molecular Mechanisms of Cancer Chemoprevention with Benzyl Isothiocyanate Anuradha Sehrawat and Shivendra V. Singh Suppression of Prostate Carcinogenesis by Dietary Isothiocyanates Young-Sam Keum Section VIII: Selenium, Herbal Medicines, Alpha Lipoic Acid, and Cancer Prevention Cancer Prevention with Selenium: Costly Lessons and Difficult but Bright Future Prospects Junxuan Lu, Cheng Jiang, and Jinhui Zhang Chemoprevention of Lung Cancer by Ginseng Michael S. You, Lucina C. Rouggly, Ming Hu, Zhen Yang, Ming You, and Yian Wang Anti-Inflammatory Botanical Dietary Supplements for Women's Health: Role in Breast Cancer Prevention? Birgit M. Dietz and Judy L. Bolton PHY906, a Cancer Adjuvant Therapy, Differentially Affects Inflammation of Different Tissues Wing Lam, Scott Bussom, Zaoli Jiang, Wei Zhang, Fulan Guan, Shwu- Huey Liu, and Yung-Chi Cheng Lipoic Acid in the Prevention and Treatment of Inflammatory Disease and Cancer Kate Petersen Shay, Regis F. Moreau, and Tory M. Hagen Section IX: Epigenetics and Chronic Inflammation Epigenetic Modifications by Dietary Phytochemicals in Cancer Prevention Tabitha M. Hardy and Trygve O. Tollefsbol Nutritional Phytochemicals and the Management of Chronic Inflammation Laura Marler and John M. Pezzuto