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This book provides a comprehensive and multidisciplinary exploration of next-generation extracorporeal blood purification technologies, bridging the gap between cutting-edge research and clinical practice. It offers an in-depth analysis of advanced filtration and adsorption systems, the integration of artificial intelligence for personalized blood purification, and the expanding role of extracorporeal therapies in multi-organ support systems, including ECMO, CRRT, and liver support. Designed for intensivists, nephrologists, anesthesiologists, biomedical engineers, and researchers, this book delivers a scientific yet practical perspective on the latest advances in extracorporeal medicine. It provides detailed discussions on clinical applications, addressing key challenges in managing sepsis, cytokine storms, acute kidney injury, and multi-organ dysfunction. Clinicians will benefit from evidence-based guidelines, clinical case studies, and decision-making algorithms that enhance the implementation of blood purification in critical care settings. Beyond conventional techniques, this work delves into emerging innovations, such as wearable and portable blood purification devices, nanotechnology applications, gene therapy, and artificial organ integration. It also examines regulatory frameworks, ethical considerations, and the global accessibility of these life-saving technologies, making it an invaluable resource for industry professionals and policymakers. By combining scientific rigor, clinical applicability, and future perspectives, this book serves as a definitive reference for healthcare professionals and researchers at the forefront of extracorporeal therapies. It highlights the future of blood purification and its potential to revolutionize critical care, organ support, and personalized medicine.