Oncologia apparato gastroenterico

Gastroesophageal Reflux Disease (GERD) is one of the most common maladies of mankind. Approximately 40% of the adult population of the USA suffers from significant heartburn and the numerous antacids advertised incessantly on national television represents a $8 billion per year drug market. The ability to control acid secretion with the increasingly effective acid-suppressive agents such as the H2 blockers (pepcid, zantac) and proton pump inhibitors (nexium, prevacid) has given physicians an excellent method of treating the symptoms of acid reflux. Unfortunately, this has not eradicated reflux disease. It has just changed its nature. While heartburn, ulceration and strictures have become rare, reflux-induced adenocarcinoma of the esophagus is becoming increasingly common. Adenocarcinoma of the esophagus and gastric cardia is now the most rapidly increasing cancer type in the Western world. The increasing incidence of esophageal adenocarcinoma has created an enormous interest and stimulus for research in this area. GERD brings together a vast amount of disparate literature and presents the entire pathogenesis of reflux disease in one place. In addition to providing a new concept of how gastroesophageal reflux causes cellular changes in the esophagus, GERD also offers a complete solution to a problem that has confused physicians for over a century. Both clinical and pathological information about reflux disease and its treatment are presented. GERD is meant to be used as a comprehensive reference for gastroenterologists, esophageal surgeons, and pathologists alike. *Outlines how gastroesophageal reflux causes cellular changes in the esophagus *Brings together the pathogenesis of the disease in one source and applies it toward clinical treatment *Tom DeMeester is THE leading international expert on reflux disease; Parakrama Chandrasoma is one of the leading pathologists in the area *Book contains approximately 350 illustrations *Ancillary web site features color illustrations: www.chandrasoma.com

Classical histology has been augmented by immunohistochemistry (the use of specific antibodies to stain particular molecular species in situ). Immunohistochemistry has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system. This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. This is the only book available that translates molecular genetics into cancer diagnosis. The methods were developed by internationally-recognized experts and presented in step-by-step manner. The results of each Immunohistochemical and in situ hybridization are presented in the form of color illustrations.

The rapid growth in the number of options available for the management of colorectal cancer presents the clinician with new opportunities and new complexities. An explosion of understanding in the basic science that underlies both the disease and its potential therapies has translated into remarkable technological advances that can now be applied. So many specialties and subspecialties have now been brought to bear that it is appropriate to attempt to bring the expertise from these areas together in one volume, so that practitioners in one aspect of colorectal cancer management can maintain knowledge and expertise regarding the capabilities of other colleagues working in this disease. Colo rectal Cancer: Multimodality Management provides a concise, focused, and current review of the methodological and technological advances that have recently occurred in the management of colorectal cancer. The book has been divided into six basic parts. The first part, dealing with epidemiology and prevention, focuses on the molecular genetic events that occur in the development of colorectal cancer, as well as on our understanding of dietary and environmental factors, and possible strategies for prevention. Part II focuses on both diagnos- tic and therapeutic radiology in the management of colorectal cancer, dealing with innumer- able advances in imaging, and with the progress in the science and art of radiation therapy. The third section deals with the surgical aspects of management of colorectal cancer, starting with surgical pathology.

Collectively, cancer of the esophagus, stomach and small intestine represent the second most common site and cause of death amongst the digestive system cancers. These disparate malignancies have one thing in common: consistently effective treatment remains elusive. This book is a comprehensive guide to diagnosis, management, and post-treatment care. Epidemiologic factors, molecular and biologic determinants, diagnostic/staging methods and treatment modalities are described for each organ site. The text is thoroughly supported by color illustrations, a key feature of the American Cancer Society Atlas of Clinical Oncology series. The expert contributors from medical, surgical and radiation oncology examine the advances in imaging, interventional gastroenterology, surgical technique, and combined modality therapy and discuss their impact in the management of this challenging group of cancers.

Written by internationally recognized authorities, this comprehensive landmark text on gastrointestinal oncology addresses biology, therapeutic modalities, and diagnosis and treatment of specific malignancies. Topics covered in this reference are multidisciplinary, and sections include GI cancer, esophageal carcinoma, gastric cancer, hepatocellular, carcinoma of the biliary tree, small bowel cancer, colorectal cancer, anal canal cancer, neuroendocrine, gastric lymphomas, and gist tumors. Each section focuses on specific disease sites and cancers and provides complete information on pathology, tumor markers, molecular biology, clinical presentation, diagnosis, staging, and therapy

Researchers have forged new understanding of colorectal cancer in recent years. That developing knowledge has led to new treatment methodologies and an increase in early detection of the disease. This text focuses on the practical application of the latest advances, emphasizing the therapeutic strategies that have now evolved. An international team of experts contributes their experience in a wide range of specialties, so that all aspects of colorectal cancer are fully explored in this volume. Proctologists, general practitioners and oncologists, as well as students in these fields, will benefit from chapters on genetics and molecular pathology and a comprehensive overview of current and developing treatments.

This volume is the first interdisciplinary medical text on prostate cancer. More than 50 chapters cover all aspects of diagnosis and screening and all forms of accepted treatments of the prostate, with emphasis on the retention of sexual and physiological function. Highlights of the book include the most exhaustive coverage currently available of advanced androgen-sensitive and androgen-refractory disease. An introductory chapter discusses the impact of advances in genetic understanding of prostate cancer on clinical practice. It is a Brandon-Hill recommended title.