Researchers have forged new understanding of colorectal cancer in recent years. That developing knowledge has led to new treatment methodologies and an increase in early detection of the disease. This text focuses on the practical application of the latest advances, emphasizing the therapeutic strategies that have now evolved. An international team of experts contributes their experience in a wide range of specialties, so that all aspects of colorectal cancer are fully explored in this volume. Proctologists, general practitioners and oncologists, as well as students in these fields, will benefit from chapters on genetics and molecular pathology and a comprehensive overview of current and developing treatments.
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Biology and Genetic Factors. Epidemiology. Hemoccult and Colorectal Screening. Prevention by Colonoscopy. Screening. Chemoprevention. Pathology. Surgery for Colonic Cancer. Laparoscopy. Minimal Invasive Surgery. The Sentinel Node. New Prognostic Factors. Systemic Adjuvant Therapy. Adjuvant Treatment in Dukes B2 Colon Cancer: Yes or No. Adjuvant Intraportal Treatment. Adjuvant Intraperitoneal Chemotherapy. Safe Administration of Perioperative Intraperiotoneal CT. Surgery of Rectal Cancer. Total Meserectal Excision. Conservative Treatment of Rectal Cancer. Radiotherapy for Rectal Cancer: The European and US Approach. Preoperative Radiochemotherapy. Radiotherapy in Rectal Carcinoma. Postoperative Histopathological Evaluation. Chemotherapy for Rectal Cancer. Treatment of Locally Advanced and Recurrent Rectal Cancer. Treatment of Anal Canal Carcinoma. Which Follow-Up After Surgery? New Methods for Early Detection of Disease Recurrence. Resection of Liver Metastases. Prevention and Treatment of Peritoneal Surface Malignancy. Surgery of Metastatic Disease. Ablative Technique for Liver Metastases. Neoadjuvant Treatment of Liver Metastases. Adjuvant Treatment After Liver Metastases Resection. Locoregional Chemotherapy for Liver Metastases. Predictive Markers in Colorectal Cancer. Mechanism of 5-FU Action in Colorectal Cancer Treatment. From the Lab to the Clinic. The Mayo Regimen The Roswell Park Regimen. Infusional 5-FU. Different Treatment Approaches. Chronomodulation of Chemotherapy. Oral 5-FU Prodrugs. 5-FU in Combination with DPD Inhibitors. Pharmacokinetic Adjustment of Chemotherapy. Combination of New Agents. Irinotecan : Mechanism of Action in Combination Therapy. Oxaliplatin: Mechanism of Action. Tomudex and the NewTS Inhibitor. Which Treatment in First Line? USA and Europe Treatment Strategies After First Line Therapy. New Chemotherapy Approaches in Colon Cancer. QOL and Methodology. Cost Assessment. Randomized Trials and Meta-analysis. Drug Development in Colorectal Cancer Treatment: USA and Europe. New Treatment Concepts. Gene Therapy. Vaccine Therapy.
