Emostasi e trombosi

"Il carattere distintivo di quest'opera nei confronti delle precedenti è l'innesto di una serie di capitoli più specialistici, che ho affidato a noti competenti nelle rispettive tematiche, ottenendo la pronta e disinteressata collaborazione di tutti coloro a cui ho rivolto l'invito".

Appreciation of the importance of platelets and coagulation factors in therothrombotic events has led to the widespread use and continuous development of new antithrombotic agents. This field of cardiovascular pharmacology has advanced at a very rapid rate. Understanding the basic principles of atherothrombosis as well as the pharmacological agents currently available or under clinical development are key to the successful treatment of patients with atherothrombotic manifestations, particularly coronary artery disease. Clinical Guide to the Use of Antithrombotic Drugs in Coronary Artery Disease presents the work of internationally renowned contributors who examine pharmacological principles, indications for use, and pitfalls of antithrombotic agents most commonly utilized in treating patients with coronary artery disease. They also describe special clinical scenarios which may call for a multi-pharmacological approach or which demonstrate various undesired effects of antithrombotic agents.

Quest'opera descrive alcuni meccanismi chiave dell'angiogenesi e le opportunità riguardanti lo sviluppo di nuove strategie in campo terapeutico. Il volume fornisce un quadro esaustivo della materia spaziando dall'embriologia dei vasi e del sistema emopoietico ai più avanzati approcci terapeutici, primo fra tutti quello che si basa sull'utilizzazione del sangue midollare autologo ad attività staminalica. Grande rilevanza viene inoltre attribuita alla patogenesi dei difetti dell'emostasi e della coagulazione, all'ipertensione arteriosa e ai difetti del quadro lipidico. L'opera si propone, pertanto, come efficace strumento di studio e di aggiornamento per gli studenti dei corsi di laurea o di specializzazione che annoverano tra le materie insegnate quelle dedicate alla trattazione del danno vascolare e della tromboemostasi, ma costituirà, senz'altro, anche uno strumento prezioso nella pratica quotidiana per angiologi, cardiologi e chirurghi vascolari, oltre che per diabetologi, gerontologi e patologi clinici.

Written by the world's foremost authorities, this volume provides comprehensive coverage of current approaches to the prevention, diagnosis, and management of atherothrombosis and its coronary and noncoronary complications. This edition has been thoroughly updated, sharply focused on clinical information, and trimmed to one manageable volume. Coverage begins with a review of risk factors and prevention, emphasizing lipid abnormalities, hypertension, smoking, diabetes, and obesity. Subsequent sections examine the pathogenesis of atherosclerosis, markers and imaging, acute coronary syndromes, chronic stable angina, and noncoronary atherothrombosis. Clinical presentations, medical management, and the latest interventional strategies are included.

It is common knowledge that thromboembolic disease is often the earliest manifestation and almost the most frequent complication of cancer. Recent studies have investigated the mechanisms by which cancer causes thrombosis and have emphasized the importance of the coagulation system in angiogenesis and tumor metastasis. Thrombosis and Cancer offers a detailed and authoritative review of the issues involved in the links between thrombosis, hemostasis, and cancer, an association long documented but still not completely understood. This text provides comprehensive and timely coverage of the current knowledge of cancer-associated thrombosis, its pathogenesis, clinical features, prevention, and therapy. It specifically addresses the relationship between hemostatic systems and cancer, thus providing a unique and much needed focus. All of the contributors are acknowledged specialists in their fields and have experience conducting large clinical trials in oncology and thrombosis. Their discussions cover all aspects of the topic, from long-term complications to cancer surgery. With input from specialists in a range of disciplines including hematology, pharmacology, and surgery, this thorough text will be of interest to general practitioners, internists, oncologists, hematologists, and all physicians involved in the management of cancer patients.

Now in its Third Edition, this authoritative text continues to provide a comprehensive and systematic review of the biology, pathobiology, and clinical disorders of the hemostatic system. Its unique organization of the basic sciences coupled with clinical sections yields a user-friendly integrated text, and a reference tool that meets the needs of diverse investigators and clinicians of contemporary medicine for understanding the hemostatic system. New chapter topics covered in this edition include angiogenesis and vasculogenesis; hemorrhagic complications of antithrombotic therapy; interactions of coagulation and fibrinolytic proteins with the vessel wall; and less common thrombotic disorders.

Manual of Coagulation Disorders disills the most clinically relevant material from the more conventional reference books. Physicians and trainees who treat thrombotic and hermorrhagic disorders will discover new insight into human diseases caused by thrombosis and bleeding. To provide comprehensive coverage, the author begins with a brief discussion of mechanisms of coagulation, venous and arterial thromboses, and associated syndromes. Readers are then taken through bleeding disorders, care of special patients, and specific complications resulting from relevant medical problems. Manual of Coagulation Disorders is THE most accessible source for cutting edge topics.

This text provides a comprehensive practical guide to the understanding and management of thromboembolytic disease. Management of thrombosis, formerly the domain of the cardiologist or haemotologist, has become an increasingly significant issue in primary care and general practice, particularly as the range of therapies available has increased. With a uniform structure taking the reader through a background pathophysiology chapter, management strategies and drug administration, this text aims to provide a valuable guide to the general physician who lacks formal training in this area plus the trainee or pracitising cardiologist, haematologist and cardiovascular surgeon. Each chapter includes an introduction, background or pathophysiology when appropriate, and comprehensive coverage of management options. It also incorporates most therapies with exact dosing and administration schedules.

This is an easy-to-carry, affordable clinical guide to the diagnosis and treatment of bleeding and clotting disorders. This guide reflects the latest scientific advances in thrombosis research, including new recommended treatment protocols. It also includes two new chapters that cover important discoveries in certain heritable blood disorders.