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Biologia molecolare

Metabolic Regulation

A Human Perspective

Keith N. Frayn

editore: Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)

pagine: 384

The important Third Edition of this successful book conveys a modern and integrated picture of metabolism and metabolic regulation. Explaining difficult concepts with unequalled clarity, author Keith Frayn provides the reader with an essential guide to the subject. Covering topics such as energy balance, body weight regulation and how the body copes with extreme situations, this book illustrates how metabolic regulation allows the human body to adapt to many different conditions. Changes throughout the new edition include: Extensive chapter updates Clear and accessible 2-color diagrams Q&A sections online at www.wiley.com/go/frayn to facilitate learning Frayn has written a book which will continue to be an extremely valuable tool for scientists, practitioners and students working and studying across a broad range of allied health sciences including medicine, biochemistry, nutrition, dietetics, sports science and nursing.
46,00 39,10

Epigenetics and Disease

En Li, Susan M. Gasser

editore: Birkhauser Verlag AG

pagine: 280

Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.
156,00 132,60

Essential stem cell methods

LANZA R. , KLIMANSKAYA I.

editore: Academic Press

pagine: 608

Stem cells are of great interest to scientists and clinicians due to their ability to differentiate into various tissues of the body, making them a promising source of cells for regenerative medicine and drug discovery as well as a model of vertebrate development. This title features a set of protocols written by experts in the field.
63,00 53,55

Stem cell anthology

Stem cell biology, tissue engineering, cloning, regenerative medicine and biology

CARLSON B.M.

editore: Academic Press

pagine: 402

110,00 93,50

Introduzione alle colture cellulari

G. Luigi Mariottini

editore: Tecniche Nuove

pagine: 133

L.utilizzo di ogni composto sintetizzato deve essere approvato da parte di organi competenti in seguito all'effettuazione di accurati studi di tossicità, ed è quindi necessaria una sperimentazione che valuti gli eventuali effetti dei composti e il rischio per gli organismi conseguente all'esposizione. Tra i metodi biologici disponibili per queste attività, i metodi in vitro e, in particolare, le colture cellulari, sono oggi ampiamente usati e conosciuti. Rivolta a tutti i titolari di laboratori e professionisti del settore delle analisi chimico-biologiche e della ricerca farmaceutica e adottata presso diverse facoltà di Biologia, la seconda edizione del manuale aggiorna e approfondisce la trattazione dei metodi che utilizzano le colture cellulari nei diversi campi della ricerca biomedica. Il testo fornisce a tutti gli operatori del settore una serie di informazioni mirate al corretto utilizzo delle tecniche di base e dei metodi di studio in questo campo di indagine moderno e fondamentale nelle scienze sperimentali, ambientali e nella sanità.
14,90 12,67
49,00 41,65
315,00 267,75
94,00 79,90

International review of cell and molecular biology Vol. 277

Vol. 277

JEON K.W.

editore: Academic Press

pagine: 259

168,00 142,80
90,00 76,50

Microarray analysis of the physical genome

Methods and protocols

POLLACK J.R.

editore: Humana Press

pagine: 223

87,00 73,95

Life Span Extension

Single Cell Organisms to Man

Antonello Lorenzini, Christian Sell
e altri

editore: Humana Press Inc.

pagine: 216

In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In "Life-Span Extension: Single-Cell Organisms to Man", the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process. Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice. Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume.
100,00 85,00

Biology of Stem Cells and the Molecular Basis of the Stem State

Dov Zipori

editore: Humana Press Inc.

pagine: 304

Biology of Stem Cells and the Molecular Basis of the Stem State concentrates upon adult stem cells, particularly on mesenchymal cell populations, which is the author's area of expertise. The text offers the reader a detailed description of the emergence of stem cell research and the dogmas that were created during the first decades of analysis of stem cell properties, particularly those of hemopoietic stem cells. Biology of Stem Cells and the Molecular Basis of the Stem State also introduces the reader to the commonly accepted notions regarding stem cell biology, with an emphasis on an alternative view of stemness, i.e. the stem state. In keeping with the popularity of this topic, Biology of Stem Cells and the Molecular Basis of the Stem State addresses the major controversies and points of dispute, among researchers in the stem cell field. Overall, Biology of Stem Cells and the Molecular Basis of the Stem State presents a well-rounded dialogue about stem cells as it not only concentrates upon the biological elements of stem cell, but also addresses the controversy and hype currently enveloping this popular subject.
155,00 131,75

Molecular Structure and Function of the Tight Junction

Jorg-Dieter Schulzke, Michael Fromm

editore: New York Academy of Sciences

pagine: 300

Aim of this volume is to clarify the relationship between molecular structure and function of tight junction proteins, as well as their regulation and their role in diseases. Current research may form a basis for future diagnostic and therapeutic approaches to diseases which seem to have not much in common but are characterized by defects of organ barriers, like Crohn's disease, renal hypertension, inner ear deafness, and cancerous diseases. Topics include the functions of distinct tight junction proteins as barrier or channel formers for solutes and water, characteristics of the tight junction in inflammatory bowel diseases, posttranslational modifications of tight junction proteins, the relation between renal tight junction proteins and blood pressure control, and the molecular structure of claudin-claudin interactions NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
94,00 79,90
115,00 97,75

Type 2 Diabetes

Claire Stocker

editore: Humana Press Inc.

pagine: 288

Diabetes is now reaching epidemic proportions, and the associated complications of this disease can be disabling and even life-threatening. In Type 2 Diabetes: Methods and Protocols, leading investigators provide up-to-date explanations of commonly used laboratory protocols used in diabetes research. Covering the commonly described in vivo and in vitro model systems, the volume ultimately leads to an overall view of how cellular dysfunction and degeneration leads to susceptibility and diabetes disease progression. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Type 2 Diabetes: Methods and Protocols offers succinct, proven techniques to aid research scientists and clinicians in continuing the study of this debilitating disease.
85,00 72,25

Therapeutic Applications of RNAi

Cristina M. Rondinone, John F. Reidhaar-Olson

editore: Humana Press Inc.

pagine: 148

The phenomenon of RNA interference has rapidly moved from groundbreaking scientific discovery to promising therapeutic approach. However, even as RNAi-based drugs enter the clinic, significant challenges remain, particulary in the area of delivery. Therapeutic Applications of RNAi provides detailed protocols in key areas of current focus, including testing of delivery vehicles, identification of appropriate model systems, and evaluation of the effects of RNAi in vivo. Produced by a team of internationally renowned authors, the volume describes the therapeutic applications of RNAi and potential pitfalls in oncology, viral infections and CNS disease, using a variety of delivery methods, including liposomes, peptide-based nanoparticles, polycationic polymers, and viral vehicles. Written in the highly successful Methods in Molecular Biologya series format, the chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Therapeutic Applications of RNAi is an ideal guide for scientists attempting to solve the numerous challenges in this field and revolutionize the treatment of disease.
78,00 66,30

Biologia molecolare della cellula

editore: Zanichelli

pagine: 1344

156,50 136,16

Manual of Stem Cell and Bone Marrow Transplantation

Deborah Yolin Raley, Joseph H. Antin

editore: Cambridge University Press

pagine: 192

Over the past 35 years, stem cell and bone marrow transplantation have evolved from experimental therapies to well-established and widely used treatments for a variety of malignant and nonmalignant conditions. This book is a practical pocket manual for all members of the stem cell and bone marrow transplant team, based on a popular in-house handbook used at the Dana-Farber Cancer Institute. The manual covers all aspects of the transplantation process, from stem cell processing through management of transplant-related complications. Evaluation and counseling of patients and donors, preventative care, and conditioning regimens are also covered, making this an ideal resource for nurses as well. The text is handily arranged in outline format to maximize the usefulness and convenience of this resource.
34,00 28,90

Medical Instrumentation Application and Design

Application and Design

John G. Webster

editore: John Wiley & Sons Inc

pagine: 720

This book provides biomedical engineers with the premiere reference on medical instrumentation as well as a comprehensive overview of the basic concepts. The revised edition features new material on infant apnea monitors, impedance pneumography, the design of cardiac pacemakers, and disposable defibrillator electrodes and their standards. Each chapter includes new problems and updated reference material that cover the latest medical technologies. The chapters have also been revised with new material in medical imaging, providing biomedical engineers with the most current techniques in the field.
180,00 153,00

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