Wiley-Blackwell

"The publication of the second edition of this manual comes at an important juncture in the history of clinical research. As advances in information technology make it possible to link individuals and groups in diverse locations in jointly seeking the answers to pressing global health problems, it is critically important to remain vigilant about moral and ethical safeguards for every patient enrolled in a trial. Those who study this manual will be well aware of how to ensure patient safety along with fiscal responsibility, trial efficiency, and research integrity." -Robert Harrington, Professor of Medicine, Director, Duke Clinical Research Institute, Durham, North Carolina, USA The Duke Clinical Research Institute (DCRI) is one of the world's leading academic clinical research organizations; its mission is to develop and share knowledge that improves the care of patients around the world through innovative clinical research. This concise handbook provides a practical "nuts and bolts" approach to the process of conducting clinical trials, identifying methods and techniques that can be replicated at other institutions and medical practices. Designed for investigators, research coordinators, CRO personnel, students, and others who have a desire to learn about clinical trials, this manual begins with an overview of the historical framework of clinical research, and leads the reader through a discussion of safety concerns and resulting regulations. Topics include Good Clinical Practice, informed consent, management of subject safety and data, as well as monitoring and reporting adverse events. Updated to reflect recent regulatory and clinical developments, the manual reviews the conduct of clinical trials research in an increasingly global context. This new edition has been further expanded to include:* In-depth information on conducting clinical trials of medical devices and biologics* The role and responsibilities of Institutional Review Boards, and* Recent developments regarding subject privacy concerns and regulations. Ethical documents such as the Belmont Report and the Declaration of Helsinki are reviewed in relation to all aspects of clinical research, with a discussion of how researchers should apply the principles outlined in these important documents. This graphically appealing and eminently readable manual also provides sample forms and worksheets to facilitate data management and regulatory record retention; these can be modified and adapted for use at investigative sites.

Removable Partial Dentures: A Clinician's Guide is a highly practical step-by-step guide to the diagnosis, treatment planning, and manufacture of removable partial prostheses. Through its systematic approach, the book demystifies the clinical practice of these procedures, providing the practitioner with essential information on this common modality for partially edentulous patients. This clinical manual offers easy-to-follow instruction on removable partial dentures, thoroughly outlining this technique in a practical format. Aimed at the new dental professional, Removable Partial Dentures provides key information for general dentists and prosthodontists.

This new resource provides a basic foundation in small animal anatomy for students of veterinary medicine, animal science, and veterinary technology. Extraordinary accuracy and beautiful original artwork make this a truly unique learning tool that includes the anatomy of all organ systems in the dog, cat, rabbit, rat, and guinea pig - all described in a consistent manner. Learning features include: carefully selected labeling helps students learn and remember structures and relationships; male and female of species are depicted on facing pages so topographic anatomy can be compared; structures common to various animals are labeled several times, whereas unique structures are labeled on one or two species so students can make rapid distinctions of the structures peculiar to certain animals; and an introduction that provides readers with a background in nomenclature and anatomic orientation so they can benefit from the atlas even if they lack training in anatomy. The Atlas depicts topographic relationships of major organs in a simple, yet technically accurate presentation that's free from extraneous material so that those using the atlas can concentrate on the essential aspects of anatomy. It will be an invaluable resource for veterinary students, teachers and practitioners alike.