Garland Publishing Inc

Case Studies in Immunology, Seventh Edition is intended for medical students and undergraduate and graduate students in immunology. It presents major topics of immunology through a selection of clinical cases that reinforce and extend the basic science. Each case history is preceded by essential scientific facts about the immunological mechanisms of that specific disorder. The cases demonstrate how immunological problems are deconstructed in the clinic and each one is followed by a concise summary of the clinical finding, key questions, and discussion points. The book includes a total of 55 cases and can be used as either a stand-alone text, review aid, or as a companion to Janeway's Immunobiology, Ninth Edition and The Immune System, Fourth Edition. Six new cases have been added to this edition: DOCK8 deficiency, activated PI3K delta syndrome, increased susceptibility to candida infections, LRBA deficiency, T cell signaling defects, and channelopathies.

M. tuberculosis remains one of the most successful human pathogens known. The causative agent of tuberculosis, it also has a unique ability to persist for years in the infected, apparently healthy host. This dormant organism can be reactivated years, even decades later to cause tuberculosis. Knowledge regarding the interaction of M. tuberculosis with the host is fundamental to understanding the pathogenesis, leading eventually to the development of strategies for the prevention and control of infection and disease. By integrating genetic, microbiologic, immunologic, and cell biologic approaches to elucidate pathogenesis, penetrating new insights into the interaction of M. tuberculosis with the host have emerged. This book reviews the most important state-of-the-art approaches currently used to study microbe-host interactions and highlights emerging methodologies. Strategies to analyze the following topics are included: mycobacterial entry, growth, and gene expression in macrophages; analysis of post-phagocytic events; analysis of signaling in infected macrophage; the acquired immune response; newer animal- and non animal-models systems; latency; and the epidemiology of M. tuberculosis infections.