Completely updated including coverage of the Parkin gene, this second edition unveils advances in the genetics of Parkinson's Disease (PD). The author reviews the role of alpha synuclein in the genesis of PD and covers tau protein and related diseases, MPTP and drug induced PD, oxidative stress, mitochondrial dysfunction, and apoptosis. He explores pharmacological approaches to the treatment of PD such as the use of COMT inhibitors and dopamine agonist and advances in technology such as devices that provide additional treatment options including deep brain stimulation and transplantation. The book concludes with new chapters covering the differential diagnosis of PD and related disorders.
Indice testuale
1. The Basal Ganglia2. Basal Ganglia, Motor Control and Parkinsonism 3. Mechanism of Cell Death in Parkinson's Disease4. The Pathology of Parkinson's Disease - Recent Advances5. Alpha-synuclein, Nigral Degeneration and Parkinsonism6. The Thalamus and Parkinson's Disease: Clinical, Pathological and Experimental Observations7. The Pedunculopontine Nucleus: Anatomy, Physiology and Function in Locomotion8. Genetics of Parkinson's Disease9. Dopamine Agonists in the Treatment of Parkinson's Disease10. COMT Inhibitors in the Treatment of Parkinson's Disease11. Surgical Treatment of Parkinson's Disease12. New Treatment Modalities in Parkinson's Disease13. Psychosis in Parkinson's Disease14. Dystonia and Parkinsonism15. Functional Imaging in Parkinson's Disease16. Restorative and Cell Transplantation in the Treatment of Parkinson's Disease17. Tauopathies and Frontotemporal Dementia18. Progressive Supranuclear Palsy19. Cortical-basal Ganglionic Degeneration20. Multiple System Atrophy21. Management of Sleep Disturbances in Parkinson's Disease22. Drug-induced Parkinsonism23. Episodic and Continuous Gait Disturbances in Parkinson's Disease24. Autonomic Disturbances in Parkinson's Disease
