This new edition covers recent advances in understanding immunological and inflammatory responses in the nervous system, research driven by the potential to use knowledge of the molecules and mechanisms involved to intervene in, and arrest, neurodegenerative disease processes. Immune and Inflammatory Responses in the Nervous System covers developmental aspects of immune/inflammatory responses in the CNS, basic aspects of glial function, as well as inflammatory mediators, their mechanisms of action, clinical importance and sites of infection. There is also coverage of the major diseases of the CNS, including stroke, brain injury, multiple sclerosis and Alzheimer's disease. Throughout, the focus is on the underlying basic neuroscience, clinical relevance and the potential for therapeutic interventions. This will be an invaluable aid to understanding and improving the diagnosis of neuroimmune diseases and determining therapeutic measures. The contributors are all leading experts in the field and the content will be of interest to neuroscientists, neurologists, neuropathologists, neurosurgeons and immunologists.
Indice testuale
1. Developmental influences on inflammation in the brain ; 2. Imaging inflammation in the brain ; 3. Astrocytic networks and brain injury ; 4. Blood-brain barrier and perivascular cells ; 5. CNS responses to peripheral insults ; 6. Inflammatory events in focal cerebral ischaemia ; 7. Cytokines and neurodegeneration ; 8. Inflammatory responses to traumatic brain injury: an overview for the millennium ; 9. Inflammatory demyelination and axonopathy in the CNS ; 10. CNS immune reactions in Alzheimer's disease ; 11. Transplantation of neuronal and non-neuronal cells into the brain
