Diagnostic Pediatric Hematopathology is unique in providing an accurate and up-to-date guide to the diagnosis of benign and malignant hematologic disorders of childhood. The text discusses the development of the hematopoietic and lymphoid systems - and how this affects normal and abnormal findings in children at various ages. Also examined are the morphologic, immunophenotypic, cytogenetic, and molecular genetic characteristics of most pediatric-specific hematologic diseases. This is an excellent reference that ensures accurate diagnoses when evaluating peripheral blood, bone marrow, and lymph nodes of children. The text is written by a team of experienced pediatric hematopathologists and clinical scientists drawn from major academic children's hospitals in the United States, Europe, and Canada. It will be a valuable tool in the every day practice of pathologists, pediatric pathologists, and hematopathologists, and a ready educational resource for fellows, pathology residents, medical students, clinical scientists in the field, and pediatric hematologists/oncologists.
Introduction Maria A. Proytcheva; Part I. General and Non-Neoplastic Hematopathology: 1. Hematologic values in the healthy fetus, neonate, and child Maria A. Proytcheva; 2. Normal bone marrow Maria A. Proytcheva; 3. Disorders of erythrocyte production: nutritional deficiencies, iron deficient, and sideroblastic anemia Angela E. Thomas and Barbara J. Bain; 4. Disorders of hemoglobin synthesis: thalassemias and structural hemoglobinopathies Alexander Kratz and Jeffrey Jhang; 5. Hemolytic anemias: immune- and non-immune-mediated hemolytic anemias, RBC membrane defects, and hereditary disorders due to RBC enzyme defects Suresh G. Shelat; 6. Inherited and acquired bone marrow failure syndromes associated with multiple cytopenias Sa A. Wang and Victor Zota; 7. Inherited bone marrow failure syndromes and acquired disorders associated with single peripheral blood cytopenia: pure red cell aplasia, agranulocytosis, and thrombocytopenias Maria A. Proytcheva; 8. Peripheral blood and bone marrow manifestations of metabolite storage diseases Andrea M. Sheehan; 9. Reactive lymphadenopathies Maria A. Proytcheva; Part II. Neoplastic Hematopathology: 10. Chromosome abnormalities of hematologic malignancies: a practical guide to cytogenetic analysis Katrin Carlson Leuer; 11. Expression profiling in pediatric acute leukemias Lawrence Jennings and Chiang-Ching Huang; 12. Myeloproliferative neoplasms Robert B. Lorsbach; 13. Myelodysplastic/myeloproliferative neoplasms John Kim Choi; 14. Myelodysplastic syndromes and therapy-related myeloid neoplasms Sa A. Wang; 15. Acute myeloid leukemia and related precursor neoplasms Robert B. Lorsbach; 16. Hematologic abnormalities in individuals with Down syndrome John Kim Choi; 17. Precursor lymphoid neoplasms Mihaela Onciu; 18. Advances in prognostication and treatment of pediatric acute leukemia Stanley Chaleff; 19. The effect of chemotherapy, detection of minimal residual disease, and hematopoietic stem cell transplantation Maria A. Proytcheva; 20. Pediatric small blue cell tumors metastatic to the bone marrow Maria A. Proytcheva; 21. Pediatric mature B-cell non-Hodgkin lymphomas Sherrie L. Perkins; 22. Pediatric mature T-cell and NK-cell non-Hodgkin lymphomas Sherrie L. Perkins; 23. Hodgkin lymphoma Mihaela Onciu; 24. Immunodeficiency-associated lymphoproliferative disorders: congenital immune deficiencies, acquired immune deficiencies, and post-transplant lymphoproliferative disorders Mihaela Onciu and J. Han van Krieken; 25. Histiocytic proliferations in childhood Ronald Jaffe; 26. Cutaneous and subcutaneous lymphomas in children Kenneth Chang, Elena Pope and Glen Taylor.