Established as the 'Bible of Rheumatology', this definitive two-volume reference is now in its thoroughly updated Fifteenth Edition. More than 200 of the world's preeminent experts provide encyclopedic coverage of the entire field of rheumatology, including relevant basic science, diagnostic and therapeutic modalities, and pathophysiology, diagnosis, and medical and surgical management of all rheumatic diseases and syndromes. Chapters include extensive references and more than 1,200 illustrations complement the text. A new co-editor, Dr. Larry Moreland, joins Dr. Koopman for this edition. Coverage includes numerous new treatment modalities, a new chapter on anti-TNF drugs, and cutting-edge molecular and genetic research.
Section I: Introduction to the Study of the Rheumatic Diseases 1. Epidemiology of the Rheumatic Diseases, D.T. Felson 2. Differential Diagnosis of the Rheumatic Diseases: Analysis of Signs and Symptoms, D.J. McCarty 3. Clinical Evaluation in the Rheumatic Diseases, N. Bellamy 4. Analysis of Synovial Fluid, Ted Mikuls 5. Arthroscopy, K.C. Kalunian 6. Magnetic Resonance Imaging of the Joints, H.K. Genant Section II: Scientific Basis for the Study of the Rheumatic Diseases 7. Structure and Function of Joints, Paul Wooley 8. Synovial Physiology, P. A. Simkin 9. Collagen Structure & Function, Richard Mayne 10. Structure, Function and Metabolism of Cartilage Proteoglycans, Anne Woods 11. Cartilage Structure and Function, A.Robin Poole 12. Structure and Function of Synoviocytes, Steffen Gay 13. Immunoglobulins & Their Genes, H.W. Schroeder 14. Structure and Function of Monocytes/Macrophages and Other Antigen Presenting Cells, Mary K. Crow 15. Structure & Function of Lymphocytes, Robert H. Carter 16. Structure & Function of Neutrophils, Bruce N. Cronstein 17. Mast Cells and Eosinophils in the Rheumatic Diseases, Allen P. Kaplan 18. Platelets in the Rheumatic Diseases, M.N. Saleh 19. Cytokines and their Receptors, Cem Gabay 20. Cell Adhesion Molecules in the Rheumatic Diseases, D.C. Bullard 21. Molecular Biology of the Complement System, J.E. Volanakis 22. Acute-Phase Proteins in the Rheumatic Diseases, J.E. Volanakis 23. Eicosanoids and Related Compounds, C.N. Serhan 24. Nitric Oxide and Related Compounds, G. S. Gilkeson 25. Characteristics of Immune Complexes and the Principles of Immune Complex Diseases, R.P. Kimberly 26. Apoptosis and Autoimmune Disease, J. D. Mountz 27. Structure, Function, and Genetics of the HLA Complex in Rheumatic Disease, Jane Buckner, Gerry Nepom 28. Genetic Basis of the Rheumatic Diseases, John B. Harley 29. Arthritis and Autoimmunity in Animals, Phil Cohen 30. Infectious Agents in Chronic Rheumatic Diseases, R. D. Inman Section III: Therapeutic Approaches in the Rheumatic Diseases 31. Nonsteroidal Anti-Inflammatory Drugs, John Sundy 32. Methotrexate & Lefunomide: Use in the Treatment of Rheumatoid Arthritis and Other Rheumatic Diseases, Graciela Alarcon 33. Combination Drug Therapy, H. J. Williams 34. Glucocorticoids, Dimitrios Boumpas 35. Arthrocentesis: Technique and Therapeutic Options, Gerald Moore 36. Bone Marrow and Stem Cell Transplantation, Lynell W. Klassen 37. Gene Therapy: Potential Applications in Arthritis, Ulf Muller-Ladner 38. Rehabilitation in the Rheumatic Diseases, Rowland W. Chang 39. Cytokine Inhibitors: Tumor Necrosis Factor and Interleukin-1, Joan Bathon 40. Potential Biological Therapies, Joseph Shanahan and Larry Moreland 41. Immunomodulatory Agents (cyclosporine, FK506, mycophenolate, azathioprine, cyclophosphamide), Grant Cannon 42. Traditional DMARDs (Gold, Sulfasalazine, D-penicillamine, Antimalarials), W. Winn Chatham 43. Alternative Therapies, Daniel Clegg