Written by leading international physicians and investigators, this innovative multi-disciplinary book presents the most up-to-date research and clinical approaches to squamous cell carcinomas of the head and neck. In recent years, great advances in translational research have lead to new treatment paradigms. This book covers such progress in a number of clinical settings including programs of organ and function preservation, curative treatments of unresectable disease, adjuvant treatments in high-risk patients, and palliative approaches for recurrent/metastatic disease. Complementary to the techniques of surgery, radiotherapy and chemotherapy, the authors present data on epidemiology, molecular pathology, normal tissue complications, rehabilitation, palliative care, treatment in the elderly, and socio-economic aspects. State-of-the-art functional imaging techniques are covered. The latest developments in high precision techniques in irradiation, sequencing treatments of chemo- and radiotherapy, as wells as the integration of biomolecular therapies into cytotoxic treatments are also explored.
Preface Chapter 1 Epidemiology and Aetiology of Head and Neck Cancers Newell W. Johnson and Hemantha K. Amarasinghe Chapter 2 Head and Neck Cancer Prevention Fausto Chiesa, Angelo Ostuni, Roberto Grigolato, Luca Calabrese Chapter 3 Cellular and Molecular Pathology of Head and Neck Tumors Adel K. El-Naggar Chapter 4 Oncogenomics/Proteomics of Head and Neck Cancers Howard S. Moskowitz and Jennifer R. Grandis Chapter 5 Genetics and Epigenetics of Head and Neck Cancer Richard J. Shaw and Jagtar Dhanda Chapter 6 Immunology of Head and Neck Cancer Steve C. Lee and Robert L. Ferris Chapter 7 HPV and EBV in Head and Neck Cancer Jeffery Brumbaugh, Robert L. Ferris, Shen Hu Chapter 8 Head and Neck Cancer Staging and Prognosis: Perspectives of the UICC and the AJCC Brian O'Sullivan and Jatin P. Shah Chapter 9 Biomarkers in Head and Neck Cancer John Wrangle, Shanthi Marur, Arlene A. Forastiere Chapter 10 Hypoxia in Head and Neck cancers: Clinical Relevance and Treatment Yungan Tao and Jean Bourhis Chapter 11 Translational Research in Head and Neck Oncology David Sung-Hyun Yoo and David M. Brizel Chapter 12 Preclinical Models of Head and Neck Squamous Cell Carcinoma Michiel W.M. van den Brekel, Ms CL Zuur, Stephen P. Malkoski, and Xiao Jing Wang Chapter 13 Morphologic Investigations in Head and Neck Cancer Suyash Mohan and Gaurang V. Shah Chapter 14 Ultrasound Investigations in Head and Neck Cancer Patients Yolanda Y.P. Lee, K.T. Wong, Ann D. King, Anil T. Ahuja Chapter 15 Functional Imaging Ludwig G. Strauss and Antonia Dimitrakopoulou-Strauss Chapter 16 Sentinel Node Biopsy for Head and Neck Cancer Lee Alkureishi and Gary L. Ross Chapter 17 Approaches to Supportive Care Barbara A. Murphy Chapter 18 Intensity-Modulated Radiation Therapy for Head and Neck Cancer Nancy Lee, Daniel Gomez, Edward J. Shin, K.S. Clifford Chao Chapter 19 Principles of Systemic Chemotherapy for Squamous Cell Head and Neck Cancer Cristina P. Rodriguez and David J. Adelstein Chapter 20 Molecular Targeted Therapies in Head and Neck Cancer Vinai Gondi, Anne M. Traynor, Paul M. Harari Chapter 21 Phase I Study Methodology in Head and Neck Oncology Christophe Le Tourneau and Lillian L. Siu Chapter 22 Evidence-Based Head and Neck Oncology: Principles and Pitfalls Soren M. Bentzen Chapter 23 Programs of Organ and Function Preservation Jean-Louis Lefebvre Chapter 24 Multidisciplinary Approach of Unresectable Disease Ricardo Hitt, Blanca Homet, Robert I. Haddad Chapter 25 Laser Endoscopic Treatment Pierre R. Moreau and Pierre H. Demez Chapter 26 Multidisciplinary Management of Skull Base and Superstructure Tumors Giulio Cantu, Carlo L. Solero, Stefano Riccio, Sarah Colombo, Madia Pompilio Chapter 27 Multidisciplinary Management of Oral Cavity and Maxillary Sinus Cancers Alexander D. Rapidis Chapter 28 Management of Nasopharyngeal Carcinoma Anne W.M. Lee, Wai Tong Ng, Tsz Kok Yau, Stephen C.K. Law, William I. Wei Chapter 29 Multidisciplinary Management of Oropharynx Carcinomas Beth M. Beadle and David I. Rosenthal Chapter 30 Multidisciplinary Management of Hypopharyngeal Carcinoma Marc Hamoir, Jean-Pascal Machiels, Sandra Schmitz, Vincente Gregoire Chapter 31 Cancers of the Larynx: Tis, T1, T2: Evaluation and Management Carol M. Lewis, Ollivier Laccourreye, Randal S. Weber, F. Christopher Holsinger Chapter 32 Diagnosis and Multidisciplinary Treatment of Laryngeal Cancers Nabil F. Saba, J. Trad Wadsworth, Jonathan J. Beitler, Fadlo R. Khuri Chapter 33 Principles and New Approaches in Surgical Reconstruction Christina Kenney Magill and Bruce H. Haughey Chapter 34 Multidisciplinary Treatment of the Neck Remco de Bree, Johannes A. Langendijk, C. Rene Leemans Chapter 35 Postoperative Management of High-Risk Resectable Head & Neck Cancer Jay S. Cooper Chapter 36 Management of Salivary Gland Cancer Laura D. Locati, Marco Guzzo, Patrizia Olmi, Lisa Licitra Chapter 37 Head and Neck Melanoma Genevieve A. Andrews and Jeffery N. Myers Chapter 38 Cervical Lymph Node Metastases of Squamous Cell Carcinoma from an Unknown Primary Site Nicholas Pavlidis and George Plataniotis Chapter 39 The Management of Thyroid and Parathyroid Cancers Ranee Mehra, Charu Aggarwal, Roger B. Cohen Chapter 40 Head and Neck Paragangliomas Matthew O. Old and James L. Netterville Chapter 41 Treatment of the Elderly Head and Neck Cancer Patient Jean-Claude Horiot and Matti S. Aapro Chapter 42 Interstitial Radiation Therapy in Cancer of the Oropharynx and Oral Cavity Peter C. Levendag, David N. Teguh, Paul I.M. Schmitz Chapter 43 Proton Beam Therapy for Head and Neck Cancer Danielle N. Margalit, Judy A. Adams, Annie W. Chan Chapter 44 Normal Tissue Complications and Protection in Head and Neck Cancer Patients Andy Trotti, Nikhil Rao, Avraham Eisbruch, David I. Rosenthal Chapter 45 Rehabilitation of Heavily Treated Head and Neck Cancer Patients Rachael E. Kammer and JoAnne Robbins Chapter 46 Salvage Therapy in Head and Neck Cancer Patients Saba Aftab, Rod Rezaee, Pierre Lavertu Chapter 47 Systemic Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck Jan B. Vermorken Chapter 48 Best Supportive Care for Palliative Treatment Michaela Salzwimmer Chapter 49 Quality of Life in Head and Neck Cancer Patients Jolie Ringash Chapter 50 Quality Assurance of Clinical Trials in the Management of Cancer in the Head and Neck Thomas J. FitzGerald, Maryann Bishop-Jodoin, Marcia M. Urie, Kenneth Ulin, Geoffrey S. Ibbott, James A. Purdy, Joel H. Saltz, Lester J. Peters, M. Giulia Cicchetti, Mitchell Schnall, Joseph Deasy, Walter R. Bosch, Michael V. Knopp, Lawrence H. Schwartz, Keith S. White, Richard Hanusik, Sandra K. Kessel, Karen Morano, Fran Laurie