It is now almost a decade since the identification of the Huntington's Disease gene and its mutation, during which time, major advances in our understanding of this disorder have been achieved. Since publication of the first two editions of this book, there have been considerable insights into how the mutation leads to the molecular pathology, neuropathology and clinical symptoms of Huntington's Disease, and experimental tools are now in place to take this research further towards new therapeutic approaches. As a result of these major advances, this well-established series of books has required radical updating. An international group of researchers and clinicians with specialist interests in HD has been commissioned to document the recent advances in our understanding of this disease. Developments in the fields of structural biology, cell biology, neurochemistry and neuropathology, with full coverage of transgenic animal models, are discussed in detail. The clinical sections cover genetic, neurological and psychiatric aspects as well as new developments in therapy.
This book will continue to provide an invaluable source of information for clinicians and scientists involved with Huntington's Disease, including geneticists, psychiatrists and neurologists, and basic science research workers in genetics and neurobiology.
Indice testuale
SECTION 1 - CLINICAL ASPECTS OF HUNTINGTON'S DISEASE ; 1. Huntington's disease: a historical background ; 2. Clinical neurology of Huntington's disease ; 3. Neuropsychological and neuropsychiatric aspects of Huntington's disease ; 4. Imaging Huntington's disease ; SECTION 2 - THE GENETICS OF HUNTINGTON'S DISEASE ; 5. Huntington's disease: genetic and molecular studies ; 6. The epidemiology of Huntington's disease ; 7. Genetic counselling and presymptomatic testing ; SECTION 3 - NEUROBIOLOGY ; 8. The neuropathology of Huntington's disease ; 9. Neurochemistry of Huntington's disease ; 10. Energy metabolism and Huntington's disease ; SECTION 4 - MOLECULAR BIOLOGY AND HUNTINGTON'S DISEASE ; 11. Structural biology of Huntington's disease ; 12. The cell biology of Huntington's disease ; 13. Mouse models of Huntington's disease ; SECTION 5 - OTHER POLYGLUTAMINE DISEASES ; 14. The polyglutamine disease ; SECTION 6 - THERAPEUTIC INTERVENTIONS ; 15. Comprehensive care in Huntington's disease ; 16. Therapeutic trials in Huntington's disease ; 17. Cell and tissue transplantation
