SECTION I. Specific malformations using the new integrative classification Revised classification Axes and gradients of the neural tube and gradients for a morphological and molecular genetic classification of nervous system malformations. Midline hypoplasias Holoprosencephaly. Septo-optic-pituitary dysplasia. Rhombencephalosynapsis. Embryology and malformations of the forebrain commissures. Disorders of segmentation of the neural tube Disorders of segmentation of the neural tube: Chiari malformations. Segmentation of the neural tube: agenesis of selective neuromeres. Cerebellar hypoplasias. Hamartomatous disorders of cellular lineage Tuberous sclerosis. Hemimegalencephaly syndrome. Disorders of radial neuroblast migration and cerebral cortical architecture. Periventricular nodular heterotopia. Gio12. Subcortical laminar (band) heterotopia. Lissencephaly type I Lissencephaly type II. Schizencephaly. Disorders of neural crest induction of non-neural tissues Neural tube programming and the pathogenesis of craniofacial clefts: the neuromeric. organization of the head and neck: Part I. Neural tube programming and the pathogenesis of craniofacial clefts: the neuromeric organization of the head and neck: Part II. The oral-facial-digital syndromes. Other dysgeneses Congential vascular malformations in childhood. Acquired, induced and secondary malformations of the developing central nervous system. SECTION II. Comparative manifestations of central nervous system malformations Epilepsy in patients with cerebral malformations. Neuromuscular disorders associated with cerebral malformations. Neuroendocrine complications of central nervous system malformations. Cerebral dysgeneses associated with chromosomal disorders. Cerebral dysgeneses secondary to metabolic diseases in fetal life. SECTION III. Diagnostic methods Imaging malformations of cortical development. Clinical neurophysiology of cortical malformations: magnetoencephalography and electroencephalography. Molecular genetic testing and genetic counselling. Embryology and neuropathological examination of central nervous system malformations. SECTION IV. Management of central nervous system malformations Medical treatment in children with central nervous system malformations. Surgical treatment of central nervous system malformations. Neurorehabilitation of children with cerebral palsy. Educational, cognitive, behavioral and language development issues.