Until recently, a modest knowledge of genetics was more than adequate for the daily practice of clinical cardiology, but advances in genetics and genomics are changing cardiovascular medicine in fundamental ways. The identification of the genetic basis of several forms of dyslipidemia, hypertension, diabetes, cardiomyopathies, and vascular diseases signalled the new importance of genetics in clinical medicine. In this timely volume, Drs. Dzau and Liew - both pioneers in the area - help cardiologists understand: * how cardiovascular genetics may remodel the way cardiovascular medicine is practiced * what material has immediate relevance to the practicing clinician * how to incorporate genetics and genomics in your practice to ensure up-to-date patient care The book opens with introductory chapters, then discusses: * cardiovascular single gene disorders * cardiovascular polygenic disorders * therapies and applications Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive.
If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.
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Contributors. Foreword. Introduction. 1 The gene in the twenty-first century. Choong-Chin Liew, Victor J. Dzau. Part I: Cardiovascular single gene disorders. 2 Monogenic hypercholesterolemia. Ruth McPherson. 3 Hypertrophic cardiomyopathy. Ali J. Marian. 4 Dilated cardiomyopathy and other cardiomyopathies. Mitra Esfandiarei, Robert Yanagawa, Bruce M. McManus. 5 The long QT syndrome. Sabina Kupershmidt, Kamilla Kelemen, Tadashi Nakajima. Part II: Cardiovascular polygenic disorders. 6 Atherosclerosis. Paivi Pajukanta, Kiat Tsong Tan, Choong-Chin Liew. 7 Heart failure. Markus Meyer, Peter VanBuren. 8 The implications of genes on the pathogenesis, diagnosis and therapeutics of hypertension. Kiat Tsong Tan, Choong-Chin Liew. Part III: Therapies and applications. 9 Gene therapy for cardiovascular disease: inserting new genes, regulating the expression of native genes, and correcting genetic defects. Ion S. Jovin, Frank J. Giordano. 10 Stem cell therapy for cardiovascular disease. Emerson C. Perin, Guilherme V. Silva. 11 Pharmacogenetics and personalized medicine. Julie A. Johnson, Issam Zineh. 12 The potential of blood-based gene profiling for disease assessment. Steve Mohr, Choong-Chin Liew. Index. Colour plates
