This book represents the final work of the late Professor C. David Marsden, who was the most influential figure in the field of movement disorders, in terms of his contributions to both research and clinical practice, in the modern era. It was conceived and written by David Marsden and his colleague at the Institute of Neurology, Prof. Ivan Donaldson. It was their intention that this would be the most comprehensive book on movement disorders and also that it would serve as the 'clinical Bible' for the management of these conditions. It provides a masterly survey of the entire topic, which has been made possible only by vast laboratory and bedside experience. Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to rare, and very rare conditions such as Niemann-Pick disease. Chapters follow a structured format with historical overviews, definitions, clinical features, differential diagnosis, investigations and treatment covered in a structured way. It is extensively illustrated with many original photographs and diagrams of historical significance. Among these illustrations are still images of some original film clips of some of Dr. Marsden's patients published here for the first time. Comprehensively referenced and updated by experts from the Institute of Neurology at Queen Square, this book is a valuable reference for, not just movement disorder specialists and researchers, but also for clinicians who care for patients with movement disorders.
SECTION 1 - INTRODUCTION ; 1. Anatomy ; 2. Functions of the basal ganglia ; SECTION 2 - THE CLINICAL APPROACH TO MOVEMENT DISORDERS ; 3. Clinical assessment ; 4. Investigation ; SECTION 3 - AKINETIC-RIGID SYNDROMES ; SECTION 3A - IDIOPATHIC/PRIMARY SYNDROMES ; 5. Parkinson's disease ; 6. Multiple system atrophy ; 7. Progressive supranuclear palsy (or Steele-Richardson-Olszewski disease) ; 8. Corticobasal degeneration ; 9. Parkinsonian-dementia syndromes ; SECTION 3B - SYMPTOMATIC PARKINSONIAN SYNDROMES INHERITED ; 10. Wilson's disease ; 11. Pantothenate kinase-associated neurodegeneration (PKAN), previously also known as Hallervorden-Spatz disease ; SECTION 3C - SYMPTOMATIC PARKINSONIAN SYNDROMES AQUIRED ; 12. Postencephalic parkinsonism ; 13. Drug-induced parkinsonism and the neuroleptic malignant syndrome ; 14. Basal ganglia calcification ; 15. Other acquired symptomatic parkinsonian syndromes ; SECTION 4 - TREMOR ; 16. Physiological and exaggerated or enhanced physiological tremor ; 17. Classical essential tremor ; 18. Isolated site-specific or task-specific tremors ; 19. Symptomatic tremors ; SECTION 5 - CHOREA ; 20. Huntington's disease ; 21. Other idiopathic choreic syndromes ; 22. Sydenham's chorea ; 23. Spontaneous oro-facial chorea and tardive dyskinesia ; 24. Other symptomatic (secondary) choreic syndromes ; 25. Ballism ; SECTION 6 - TICS ; 26. Simple tics ; 27. Gilles de la Tourette's syndrome ; 28. Symptomatic (secondary) tic syndromes ; SECTION 7 - MYOCLONUS ; 29. Focal myoclonus ; 30. Epileptic myoclonus ; 31. Brainstem myoclonus and startle syndromes ; 32. Specific myoclonic syndromes ; 33. Other, specific causes of symptomatic generalised myoclonus ; 34. Essential myoclonus ; SECTION 8 - PRIMARY IDIOPATHIC DYSTONIC SYNDROME ; SECTION 8A - PRIMARY IDIOPATHIC DYSTONIC SYNDROME ; 35. Generalised primary dystonia ; 36. Other primary dystonias (dystonia-plus syndromes) ; 37. Idiopathic (primary) cranial dystonias ; 38. Spasmodic torticollis ; 39. Writer's and craft cramps ; SECTION 8B - SECONDARY (SYMPTOMATIC) DYSTONIC SYNDROMES ; 40. Lesch-Nyhan syndrome ; 41. Other inherited secondary (symptomatic) dystonias ; 42. Cerebral palsy ; 43. Other acquired secondary (symptomatic) dystonic syndromes ; SECTION 9 - SYNDROMES OFCONTINUOUS MUSCLE FIBRE ACTIVITY ; 44. Stiff man syndromes ; 45. Neuromyotonic syndromes ; SECTION 10 - RESTLESSNESS ; 46. Akathisia ; 47. Restless legs syndrome ; 48. Painful legs and moving toes ; SECTION 11 - EPISODIC MOVEMENT DISORDERS ; 49. Paroxysmal choreic, athetotic or dystonic attacks ; 50. Tonic attacks ; 51. Intermittent ataxias ; 52. Miscellaneous movement disorders
