This text provides oncology professionals with a practical understanding of the basic science, technical aspects, and clinical indications of stereotactic body radiation therapy, including radiosurgery, radiotherapy, and radioablation. The coverage includes discussions of relevant classical and molecular radiobiological principles, critical evaluations of currently used techniques, and background clinical oncology information plus summaries of reported outcomes for patients treated in the lung, liver, and spine.
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Introduction (Kavanagh, UC; Timmerman, IU) 3 pp Prologue: The Clinical Transition from Cranial to Extracranial Stereotactic Radiation Therapy (Lax & Blomgren)-3 pp I. The Radiobiology of Extracranial Stereotactic Radiation Therapy (SBRT) 36 pp Tumor Dose-Response Relationships in SBRT: Do traditional Models Apply? (Fowler & Welsh & Tome) 6 pp The intracellular signaling response to high dose radiation (Dent) 6 pp Normal tissue Dose-constraints in Lung SBRT (Timmerman) 6 pp Normal tissue Dose-constraints in Liver SBRT (Herfarth & Wulf) 6 pp Radiation-induced cytokine production: mechanisms and potential clinical implications (Okunieff) 6 pp Special topics: the dose rate effect, margin selection, and resistant subpopulations (Kavanagh, Cardinale) 6 pp II. The Physics and Dosimetry of SBRT 24-28 pp Immobilization, Localization, and Repositioning Methods in SBRT (Benedict)- 10 pp Treatment Planning (Papiez & Moskvin) 8-10 pp Quality Assurance in SBRT (Haedinger) 6-8 pp III. Initiating an SBRT Program 9-12 pp Equipment and physical layout (Steiber & Hinson) 3-4 pp Commissioning and accreditation (Galvin, Ibbot) 3-4 pp Personnel Training (Nedzi) 3-4 pp IV. Clinical Applications of SBRT approx. 50 pp SBRT for lung tumors (Song & Blomgren) 6-8 p Case Studies in Lung SBRT: 9pp Uematsu 3 pp McGarry 3 pp Nagata 3 pp SBRT for Liver Tumors (Cardenes & Schefter) 6-8 pp Case Studies in Liver SBRT: 9pp Lohr, Manheim 3 pp Schefter, UC Cardenes IU 3 pp Fuss & Salter 3 pp SBRT for renal cell carcinoma (Wersall & Kavanagh) 4-5 pp SBRT in retroperitoneal and pelvic tumors (Buatti & Meeks) 4-5 pp Case Study in Pelvic SBRT 3pp Madsen, Virginia Mason Spinal Radiosurgery (Lovelock) 4-5 pp Case studies in spine Radiosurgery 6 pp Ryu 3 pp Crownover 3 pp Epilogue: Group Protocols and Future Directions in SBRT (Kavanagh, Timmerman) 3-4 pp
