Nuclear Medicine techniques have advanced to such a degree that biochemical transparency of the human body has reached the doorstep of medical application. The book gives background, techniques and examples in an interdisciplinary approach to quantify biochemical reactions in vivo by regional imaging and in vitro analyses. The goal is to assess in vivo biochemical homeostatic circuits under control by genes and protein interactions. It becomes apparent how nuclear medicine can aid clinical researchers and practitioners, human geneticists and pharmacologists in understanding (and affecting) gene-phenotype relationships operating in vivo and thus can help eventually to bring functional genomics and proteomics to clinical medicine.
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From the contents: Feinendegen et al.: Measurements of Biochemical Reactions in Vivo; Passarge: The Human Genome and Disease; Kley et al: Functional Genomics and Proteomics; Fischer: How Proteins Speak with one Another in Cell Signaling; Eckelman: Labeled Agents as Tracers and Carriers: Theory and Practice; Sharp et al: Instrumentation for Measuring Metabolism; Gjedde: Modelling Metabolite and Tracer Kinetics; Bassingthwaighte: Compound Delivery and Local Blood Flows; Dawson et al: Endothelium and Compound Transfer; Rosenthall: Coagulation and Peripheral Vascular Disease; Rennen et al: Molecular Imaging of Infection and Inflammation; Shreeve et al: Element of Metabolism and Body Composition; Pierson/Shreeve: The Biology of Aging and Related Nuclear Medicine Studies; Shreeve: In Vitro Indicators of Metabolism of Natural Compounds; Konishi et al: Endocrinology; Epstein/Bergmann: Non-invasive Assessment of Inherited Cardiac Disease; Egert/Schwaiger: Molecular Background of FDG Uptake in the Ischemic Heart; Volkow et al: Imaging Studies in Substance Abuse; Kuwert: Imaging of Cerebral Metabolism in Huntington's Disease; Fowler et al: Monoamine Oxidase: Radiotracer Development and Human Studies.
