Overview and introduction. Genetic epidemiology of hypertension and its complications. Meta-analyses in genetics: examples from the renin-angiotensin system. Gene-gene and gene-environment interactions in normotensive and hypertensive populations. Genetic studies of inherited hypertension in the rat. Genetic studies of inherited hypertension in the mouse. Transgenic rats and hypertension. Gene targeting in mice to study blood pressure regulation. Monogenic syndromes leading to hypertension and hypotension. Candidate genes within the renin-angiotensin system in essential hypertension. Genetics of pre-eclamsia. Genetics of stroke. Adducin gene as a paradigm for functional studies. Genome scans in hypertension. Comparative genome analysis. Attaching physiology to the genome. Pharmacogenetics and pharmacogenomics in cardiovascular medicine. Gene therapy for hypertension: fact or fiction?.