THE encyclopedic guide to hepatology - for consultation by clinicians and basic scientists Previously the Oxford Textbook of Clinical Hepatology, this two-volume textbook is now with Blackwell Publishing. It covers basic, clinical and translational science (converting basic science discoveries into the practical applications to benefit people). Edited by ten leading experts in the liver and biliary tract and their diseases, along with outstanding contributions from over 200 international clinicians, this text has global references, evidence and extensive subject matter - giving you the best science and clinical practice discussed by the best authors. It includes unique sections on: * Symptoms and signs in liver disease * Industrial diseases affecting the liver * The effects of diseases of other systems on the liver * The effects of liver diseases on other systems It's bigger and more extensive than other books and discusses new areas in more depth such as stem cells, genetics, genomics, proteomics, transplantation, mathematics and much more. Plus, it comes with a fully searchable CD ROM of the entire content. Click here to view a sample chapter on the liver and coagulation
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Section 1 Architecture of the liver. 1.1 Macroscopic anatomy of the liver. Jean H.D. Fasel, Holger Bourquain, Heinz-Otto Peitgen and Pietro E. Majno. 1.2 Liver and biliary tract histology. Paulette Bioulac-Sage, Brigitte Le Bail and Charles Balabaud. 1.3 Ultrastructure of the hepatocyte. Zahida Khan, James M. Crawford and Donna B. Stolz. 1.4 Liver sinusoidal endothelial cells. David Semela and Vijay H. Shah. 1.5 Kupffer cells. Hartmut Jaeschke. 1.6 The hepatic stellate cell. Massimo Pinzani. 1.7 Biliary epithelial cells. Jean-Francois Dufour. 1.8 Hepatic stem cells. Tania Roskams. 1.9 Embryology of the liver and intrahepatic biliary tract. Frederic P. Lemaigre. Section 2 Functions of the liver. 2.1 Hepatic circulation. 2.1.1 Regulation of hepatic blood flow. Christophe Bureau, Jean-Marie Peron and Jean-Pierre Vinel. 2.1.2 Hepatic microcirculation. Yoshiya Ito and Robert S. McCuskey. 2.1.3 Hepatic lymph and lymphatics. Glen A. Laine and Charles S. Cox Jr. 2.2 Functions of the liver. 2.2.1 Functional organization of the liver. Paulo Renato A.V. Correa and Michael H. Nathanson. 2.2.2 Cell biology of the hepatocyte. Allan W. Wolkoff and Phyllis M. Novikoff. 2.2.3 Molecular biology of the liver cell. Sundararajah Thevananther and Saul J. Karpen. 2.2.4 Hepatic transport processes. Ronald P.J. Oude Elferink. 2.2.5 Modulation of liver function by hepatic nerves. Gerhard P. Puschel. 2.2.6 In vitro techniques: isolated organ perfusion, slices, cells and subcellular elements. Bruno Stieger. 2.3 Metabolism. Intermediate metabolism. 2.3.1 Carbohydrates and the liver. Guenther Boden. 2.3.2 Lipoprotein metabolism. Erez F. Scapa, Keishi Kanno and David E. Cohen. 2.3.3 Protein and amino acid metabolism. Margaret E. Brosnan and John T. Brosnan. 2.3.4 Mitochondria and energy formation. Dominique Pessayre. Liver-specific functions. 2.3.5 Bilirubin metabolism. Namita Roy-Chowdhury, Yang Lu and Jayanta Roy-Chowdhury. 2.3.6 Metabolism of bile acids. Peter L.M. Jansen and Klaas N. Faber. 2.3.7 Ammonia, urea production and pH regulation. Dieter Haussinger. 2.3.8 Protein synthesis and degradation in the liver. Armin Akhavan and Vishwanath R. Lingappa. 2.3.9 Glutathione. Jose C. Fernandez-Checa and Carmen Garcia-Ruiz. 2.3.10 Haem biosynthesis and excretion of porphyrins. Herve Puy and Jean-Charles Deybach. Metabolism of endo/xenobiotics. 2.3.11 Vitamins and the liver (A and D). Masataka Okuno, Rie Matsushima-Nishiwaki and Soichi Kojima. 2.3.12 Normal iron metabolism. Kyle E. Brown. 2.3.13 Normal copper metabolism and reducing copper to subnormal levels for therapeutic purposes. George J. Brewer, Edward D. Harris and Fred K. Askari. 2.3.14 Trace elements and the liver. Brent A. Neuschwander-Tetri. 2.3.15 Hepatic metabolism of drugs. Chris Liddle and Catherine A.M. Stedman. 2.4 Synthetic function. 2.4.1 Albumin and other carrier proteins. Richard A. Weisiger. 2.4.2 The liver and coagulation. Maria T. DeSancho and Stephen M. Pastores. 2.4.3 Function and metabolism of collagen and other extracellular matrix proteins. Rebecca G. Wells. 2.5 Regulation of the liver cell mass. 2.5.1 Control of liver cell proliferation. Nisar P. Malek and K. Lenhard Rudolph. 2.5.2 Regeneration of chronically injured liver. Anna Mae Diehl. 2.6 Excretion. 2.6.1 Physiology of bile formation. Martin Wagner and Michael Trauner. 2.6.2 Motility of the biliary tree. Mayank Bhandari and James Toouli. 2.7 Immunology of the liver. 2.7.1 Cytokines in liver physiology and liver pathology. Tom Luedde and Christian Trautwein. 2.7.2 Intrahepatic lymphocytes. Wajahat Z. Mehal. 2.7.3 Antibody production and transport in the liver. Alvin B. Imaeda and Wajahat Z. Mehal. Section 3 Basic concepts in pathobiology. 3.1 Hepatocyte apoptosis and necrosis. Henning Schulze-Bergkamen, Marcus Schuchmann and Peter R. Galle. 3.2 Ischaemia-reperfusion injury to the liver. Nazia Selzner and Pierre A. Clavien. 3.3 Genetics and liver diseases. 3.3.1 Genetic polymorphisms in liver disease. Hongjin Huang and Ramsey Cheung. 3.3.2 Immunogenetics of liver disease. Peter T. Donaldson. 3.3.3 Genetic determinants of complex liver diseases: mouse models and quantitative trait locus analysis. Frank Lammert. 3.4 Cellular cholestasis. Stefano Fiorucci. 3.5 Oncogenes and tumour suppressor genes. Dipankar Chattopadhyay and Helen Reeves. 3.6 Genomics, gene arrays and proteomics in the study of liver disease. Geoffrey W. McCaughan, Nicholas A. Shackel, Rohan Williams, Devanshi Seth, Paul S. Haber and Mark D. Gorrell. Section 4 Pathology. 4.1 Histological features. Valeer J. Desmet, Tania Roskams and Miguel Bruguera. 4.2 Classifications, scoring systems and morphometry in liver pathology. Pierre Bedossa and Valerie Paradis. Section 5 Investigation of hepatobiliary disease. 5.1 Signs and symptoms of liver disease. Jurg Reichen. 5.2 Biochemical investigations in the management of liver disease. Igino Rigato, J. Donald Ostrow and Claudio Tiribelli. 5.3 Hepatic removal kinetics: importance for quantitative measurements of liver function. Susanne Keiding and Michael Sorensen. 5.4 Immunological investigations in liver diseases. Elmar Jaeckel and Michael P. Manns. 5.5 Biopsy and laparoscopy. Arthur Zimmermann. 5.6 Imaging of the liver. 5.6.1 Ultrasonography. Luigi Bolondi, Valeria Camaggi and Fabio Piscaglia. 5.6.2 Computerized tomography imaging of the liver. Daniel T. Cohen and Dushyant V. Sahani. 5.6.3 Magnetic resonance imaging. Christoforos Stoupis. 5.6.4 Angiography. Sanjeeva P. Kalva and Dushyant V. Sahani. 5.6.5 Endoscopic retrograde cholangiopancreatography. Alan J. Wigg and James Toouli. 5.7 Interventional radiology in hepatobiliary diseases. Jose Ignacio Bilbao Jaureguizar, Concepcio Bru, Joan Falco Fages and Lluis Donoso. 5.8 Positron emission tomography of the liver. Susanne Keiding and Michael Sorensen. 5.9 Splanchnic haemodynamic investigations. Didier Lebrec and Richard Moreau. 5.10 The Cochrane Hepatobiliary Group. Christian Gluud, on behalf of the Cochrane Hepatobiliary Group. Section 6 Cirrhosis. 6.1 The evolution of cirrhosis. John P. Iredale and I. Neil Guha. 6.2 Cellular and molecular pathobiology of liver fibrosis and its pharmacological intervention. Scott L. Friedman. 6.3 Clinical and diagnostic aspects of cirrhosis. I. Neil Guha and John P. Iredale. Section 7 Portal hypertension and its complications. 7.1 Anatomy of the portal venous system in portal hypertension. J. Michael Henderson. 7.2 Pathogenesis of portal hypertension. Roberto J. Groszmann and Juan G. Abraldes. 7.3 Clinical manifestions and management of bleeding episodes in cirrhotics. Jaime Bosch, Juan G. Abraldes and Juan Carlos Garcia-Pagan. 7.4 Haemodynamic assessment of portal hypertension. Juan Carlos Garcia-Pagan, Juan Turnes and Jaime Bosch. 7.5 Pathogenesis, diagnosis and treatment of ascites in cirrhosis. Vicente Arroyo, Carlos Terra and Luis Ruiz-del-Arbol. 7.6 Hepatorenal syndrome. Pere Gines and Monica Guevara. 7.7 Pulmonary complications of portal hypertension. Michael J. Krowka. 7.8 Hepatic encephalopathy. Dieter Haussinger and Andres T. Blei. 7.9 Bacterial infections in portal hypertension. Javier Fernandez and Miguel Navasa. 7.10 Hypersplenism. P. Aiden McCormick. Section 8 Congenital hepatic fibrosis and non-parasitic cystic lesions of the liver and bile ducts. 8.1 Congenital conditions. 8.1.1 Congenital hepatic fibrosis. Jean-Pierre Benhamou. 8.1.2 Simple cyst of the liver. Valerie Vilgrain. 8.1.3 Polycystic kidney disease. Valerie Vilgrain. 8.1.4 Polycystic liver disease. Valerie Vilgrain. 8.1.5 Biliary hamartomas. Valerie Vilgrain. 8.1.6 Peribiliary cysts. Valerie Vilgrain. 8.1.7 Caroli syndrome. Jean-Pierre Benhamou. 8.1.8 Choledochal cyst. Jean-Pierre Benhamou. 8.1.9 Ciliated hepatic foregut cyst. Jean-Francois Cadranel. 8.2 Acquired conditions. 8.2.1 Inflammatory cystic diseases. Jean-Francois Cadranel. 8.2.2 Neoplasms including cystadenoma. P. Starkel and Andre P. Geubel. 8.2.3 Post-traumatic cystic diseases. Jean-Francois Cadranel. Section 9 Viral infections of the liver. 9.1 Viral hepatitis. 9.1.1 Viral hepatitis. Mario Rizzetto and Fabien Zoulim. 9.1.2 The viruses of hepatitis. i) Structure, replication and laboratory diagnosis of hepatitis B virus and hepatitis D virus. Stephan Schaefer and Wolfram H. Gerlich. ii) Structure, replication and laboratory diagnosis of hepatitis C virus. Ralf Bartenschlager. iii) Hepatitis A. Loriana Di Giammarino and Jules L. Dienstag. iv) Hepatitis B. Geoffrey M. Dusheiko. v) Hepatitis D. Antonella Smedile and Mario Rizzetto. vi) Hepatitis C. Alfredo Alberti and Luisa Benvegnu. vii) Hepatitis E. Rakesh Aggarwal and Krzysztof Krawczynski. 9.1.3 Prevention and treatment of viral hepatitis. i) Vaccines against hepatitis A. Pierre Van Damme, Koen Van Herck and Philippe Beutels. ii) Hepatitis B vaccines and immunization. Daniel Lavanchy. iii) Therapy of acute viral hepatitis. Markus Cornberg, Heiner Wedemeyer and Michael P. Manns. iv) Antiviral therapy of chronic hepatitis B. Fabien Zoulim and Mario Ri
