Preface; Part I. Basic Mechanisms: 1. Conduction studies in multiple sclerosis Kai M. Rosler and Christian W. Hess; 2. The physiopathology of multiple sclerosis Giancarlo Comi; 3. Synaptic changes in multiple sclerosis. Do they occur? How effectively can they be analyzed? Vincenzo Zimarino, Maddalena Ripamonti, Marcello Belfiore, Mattia Ferro and Antonio Malgaroli; 4. Sodium channel expression and function in multiple sclerosis Lakshmi Bangalore, Joel A. Black, Michael D. Carrithers and Stephen G. Waxman; 5. Basic mechanisms of functional recovery Bjorn Zorner and Martin E. Schwab; 6. The adult human oligodendrocyte precursor cell: a key player in myelin repair Julia M. Rist and Robin J. M. Franklin; 7. Tissue regeneration and repair in multiple sclerosis: the role of neural stem cells Stefano Pluchino, Roberto Furlan, Luca Muzio and Gianvito Martino; 8. Schwann cells as a potential cell-based therapy for multiple sclerosis Violetta Zujovic and Anne Baron-Van Evercooren; Part II. Assessment of Mechanisms and Disease Status: 9. MRI to study white matter damage in multiple sclerosis Marco Rovaris, Annalisa Pulizzi and Massimo Filippi; 10. MRI to assess gray matter damage in multiple sclerosis Massimo Filippi, Federica Agosta and Maria A. Rocca; 11. Application of fMRI in multiple sclerosis Massimo Filippi and Maria A. Rocca; 12. fMRI in focal CNS damage Patrizia Pantano and Eytan Raz; 13. Electrophysiological assessment in multiple sclerosis Letizia Leocani and Giancarlo Comi; 14. fMRI monitoring of therapeutic interventions in multiple sclerosis Massimo Filippi and Maria A. Rocca; Part III. Rehabilitation - General Aspects: 15. How to measure the effects of rehabilitation Stefan J. Cano and Alan J. Thompson; 16. Value and limits of rehabilitation in multiple sclerosis Serafin Beer; 17. Prognosis in neurorehabilitation Angelo Ghezzi and Annalisa Rizzo; 18. Clinical trials to test rehabilitation Alessandra Solari; Part IV. Rehabilitation - Sectorial Interventions: 19. Spasticity in multiple sclerosis Mauro Zaffaroni; 20. Cognitive rehabilitation in multiple sclerosis Dawn W. Langdon; 21. Disorders of mood and affect in multiple sclerosis Anthony Feinstein and Omar Ghaffar; 22. Bladder dysfunction in multiple sclerosis Clare J. Fowler and Gustav Kiss; 23. Ataxia and imbalance in multiple sclerosis Luigi Tesio; 24. Sexual problems in multiple sclerosis Per Olov Lundberg; 25. Bulbar problems in multiple sclerosis Susan L. McGowan, Lucy Rodriguez and Clare Laing; 26. Back home Carlo Pozzilli and Emanuela Onesti; Index.