BASIC PATHOLOGY The nature of pathology. Cell injury and its manifestations. Cell and tissue death. Acute inflammation I: Introduction. Acute inflammation II: Cellular events. Factors which modify the inflammatory reaction. The natural history of acute inflammation I: Healing. The natural history of acute inflammation II: Wound healing. The natural history of acute inflammation III: Chronicity. The immune system. Disorders related to the immune system. Autoimmune disease. Transplantation and the major histocompatibility complex. Granulomatous inflammation. Some specific granulomatous disorders. Amyloid and the amyloidoses. General pathology of viral infections. Disorders of blood flow. Ischaemia and infarction. Abnormal accumulations of fluid and disturbances of blood distribution. Pigmentation and heterotropic calcification. Neoplasia: disorders of cell proliferation and differentiation. Non-neoplastic disturbances in cell growth and proliferation. Cell proliferation and differentiation in relation to neoplasia. Relationship of neoplastic cells with their environment: Tumour spread. Effects of neoplasms on the host. Effect of the host on neoplasms. Oncogenesis and the molecular biology of cancer. Oncogenesis. Genetic disorders. Single gene defects. SYSTEMIC PATHOLOGY The cardiovascular system. The respiratory system. The gastrointestinal system. The liver, biliary system and exocrine pancreas. The kidney. The lower urinary tract. The male reproductive system. The female reproductive system. The endocrine system. The haemopoietic system. The lymphoreticular system. The skin. The skeletal system. The nervous system. Special senses.