Neurologia

Invaluable for all members of the stroke team, this expertly written book compiles the full range of diagnostic and interventional therapeutic techniques for acute stroke now in use in modern clinical settings throughout the world. From advanced neuroimaging studies to state-of-the art endovascular therapies, it covers the materials, instruments, devices, procedures, and strategies that lead to optimal results, and most benefit the patient, during this time-critical event. Special Features: * An interdisciplinary approach* Provides detailed how-to descriptions of all endovascular stroke treatment techniques, periprocedural monitoring, and instrumentation, with a focus on implementing these methods in everyday practice* Logically organized in didactically structured chapters on diagnosis and treatment, with sections on acute ischemic stroke, acute venous occlusions, and supra-aortic extra- and intracranial stenoses, including their etiology, pathogenesis, symptoms, imaging studies, and recommended therapies for each condition* Written by a team of renowned international specialists, who provide advice, recommendations, and practical guidelines in every chapter* Discusses the stents, retrievers, filters, and balloon systems in use today * Includes nearly 300 key images taken with the latest generation of imaging equipment * Shares helpful clinical insights in sidebar notes, cautions, tips and advice, possible complications, sources of error, and useful chapter summaries/conclusions For all neuroradiologists, radiologists, neurosurgeons, and neurologists who need concise, clinically relevant information on front-line interventional techniques for stroke treatment and prevention, this book is essential. It reviews all current methods, rates their efficacies, and makes progress toward a uniformity of protocols that can be applied in all practices managing stroke patients.

Accurate interpretation of indications for treatment is the cornerstone of success in medicine. This book carefully examines the relation between clinical features, diagnosis, and choice of minimally invasive technique for a range of spine pathologies. It explains how selection of technique is intimately related to clinical and diagnostic aspects and how recognition of this relation forms the foundation for an optimal outcome. In addition to examining the various minimally invasive options, including the latest techniques, careful attention is paid to the role of medical treatment in avoiding recurrence after initial therapy. Nerve blocks, epidural injections, and intradiscal procedures are among the many options available in the armamentarium of the interventionalist, and advice is given on their use in different contexts. This volume will be of great value for neuroradiologists and others responsible for treating patients with spine disorders.

Pain is one of the most common symptoms of neurological disease and its appropriate management is essential to the effective care of patients. Neurological disorders differ in their specific pain phenotype, mechanisms and therapy. Case Studies in Neurological Pain addresses the specific pain issues, treatment and pathophysiology in patients with a wide spectrum of neurological disease. Clinical case studies have long been recognized as a useful adjunct to problem-based learning and continuing professional development. They emphasize the need for clinical reasoning, integrative thinking, problem-solving, communication, teamwork and self-directed learning - all desirable generic skills for health care professionals. Presenting real-life cases - covering conditions including diabetic and idiopathic polyneuropathies, focal neuropathies, multiple sclerosis and headache disorders - this book provides neurologists, neurosurgeons, pain clinic specialists and primary care physicians with an understanding of problems encountered in neurological practice. There are also chapters on mechanisms of neurological pain and new treatment guidelines.

Peripheral Nerve Injuries: A Clinical Guide is a fully illustrated and informative reference on injuries within the peripheral nervous system. It incorporates new knowledge in molecular and cellular events which underlie the response of nerves to injury, regeneration and neuropathic pain. Written by a leading expert in the field, Peripheral Nerve Injuries: A Clinical Guide, is a valuable resource for surgeons in residence and training.

Despite significant progress in the treatment of head and neck cancer using new techniques, including organ preservation strategies, recurrence still occurs in up to 50% of patients with locally advanced disease. Head and Neck Cancer Recurrence is the first comprehensive, evidence-based reference on this complex condition, providing state-of-the-art strategies for treating and managing recurrence at each site within the head and neck. With this book at hand, specialists will have guidelines for detecting the presence of a tumor, evaluating the extent and likelihood of successful salvage, determining the most effective treatment modalities, and assessing the potential impact on outcome and function. Special features:* Brings together all the current evidence and expertise on the epidemiology, risk factors, clinical and imaging evaluation, and management of recurrent head and neck cancer tumors* Includes both curative and palliative approaches, and discusses surgical, radiotherapeutic, and chemotherapeutic strategic options* Contains substantial contributions by specialists in speech and language therapy, palliative care, psychology, epidemiology, and clinical cancer nursing to provide a holistic, multidisciplinary approach to the management of recurrence of head and neck cancers* Brings the decision-making process to life with illustrative case studies that contain patient histories, clinical findings, treatment planning, and documented results The combination of the most recent clinical advances with the latest thinking in the field makes this book an essential resource for all head and neck surgeons, clinical oncologists, radiation oncologists, nurse practitioners, allied health professionals and senior trainees working to improve patient management and outcomes in this challenging arena.

"Operative Techniques in Spine Surgery" provides full-color, step-by-step explanations of all operative procedures in spine surgery. It contains 19 chapters from the spine section and 10 chapters from the pediatric section of Dr. Sam W. Wiesel's "Operative Techniques in Orthopaedic Surgery", as well as 18 new chapters covering advanced procedures. Written by experts from leading institutions around the world, this superbly illustrated volume focuses on mastery of operative techniques and also provides a thorough understanding of how to select the best procedure, how to avoid complications, and what outcomes to expect. The user-friendly format is ideal for quick preoperative review of the steps of a procedure. Each procedure is broken down step by step, with full-color intraoperative photographs and drawings that demonstrate how to perform each technique. Extensive use of bulleted points and tables allows quick and easy reference. Each clinical problem is discussed in the same format: definition, anatomy, physical exams, pathogenesis, natural history, physical findings, imaging and diagnostic studies, differential diagnosis, non-operative management, surgical management, pearls and pitfalls, postoperative care, outcomes, and complications.

"Dynamic Structure of NREM Sleep" is a concise guide to Cyclic Alternating Pattern (CAP) phenomenology and slow wave homeostasis. It presents an original approach to a specialized aspect of sleep neuroscience in a concise and easy-to-read format. The authors are specialists in the field of sleep neuroscience and lend a new perspective to the benefits of slow wave activity during sleep. The main feature of this discussion is that slow wave activity increases as a function of previous wakefulness and it gradually decreases in the course of sleep. Alongside developing this idea, this book covers the entire range of sleep issues from basic structure to function in comprehensive detail. "Dynamic Structure of NREM Sleep" is valuable reading for neurologists, sleep neuroscientists and those with an interest in the field.

Over the past ten years, there has been an increasing recognition that syndromes of frontotemporal dysfunction (FTD) are a common occurrence in patients with amyotrophic lateral sclerosis (ALS). Such syndromes may be present in as many as 60% of patients with ALS. Conversely, the occurrence of motor neuron dysfunction in patients with clinically pure frontotemporal dementia is increasingly recognized. This suggests that to some extent there are overlapping syndromes in which both ALS and FTD occur within the same individual. This volume summarizes the advances in our understanding of these two disorders, as well as the potential relationship between the two. Key topics include advances in our ability to clinically describe the frontotemporal syndromes, preclinical detection, neuroimaging, and genetics. The exploding field of new markers in neuropathology is examined, as is the role of new genetic mutations in DNA/RNA transport systems. This book is the essential reference text for this topic, and will be of interest to neurologists and neurological trainees with a clinical or research interest in the FTDs or ALS, neuropsychologists, neuropathologists, and researchers.

Presented in a highly efficient question-and-answer format, The Essential Neurosurgery Companion is a portable handbook for quick referencing of key concepts encountered in neurosurgical practice. With a strong focus on the realities residents face each day, the book covers practical issues such as how to apply to residency programs, what to do during rounds, and how to examine patients, as well as more advanced issues in all areas of neurosurgical management. Key Features: * More than 5,000 individual questions with corresponding answers in tabular format distill large amounts of information * Detailed color illustrations create visual summaries of complex content * A logical progression of difficulty, from basic concepts to high-level surgical topics * Reviews both key fundamentals and more advanced clinical concepts in neurosurgery * Includes a helpful appendix highlighting surgical anatomy pearls Residents involved in the practice of neurosurgery around the globe will want this compelling guide in their armamentarium whether for daily rounds or preparing for boards. Clinicians will find it a valuable resource to consult in everyday practice.

The Primer on the Autonomic Nervous System presents, in a readable and accessible format, key information about how the autonomic nervous system controls the body, particularly in response to stress. It represents the largest collection of world-wide autonomic nervous system authorities ever assembled in one book. It is especially suitable for students, scientists and physicians seeking key information about all aspects of autonomic physiology and pathology in one convenient source. Providing up-to-date knowledge about basic and clinical autonomic neuroscience in a format designed to make learning easy and fun, this book is a must-have for any neuroscientist's bookshelf!

Fully revised and updated, the Handbook serves as a practical guide to endovascular methods and as a concise reference for neurovascular anatomy and published data about cerebrovascular disease from a neurointerventionalist's perspective. Divided into three parts, the book covers: Fundamentals of neurovascular anatomy and basic angiographic techniques; Interventional Techniques and endovascular methods, along with useful device information and tips and tricks for daily practice; Specific Disease States, with essential clinical information about commonly encountered conditions. New features in the 2nd Edition include: Global Gems that illuminate aspects of the field outside the United States; Angio-anatomic and angio-pathologic image correlates; Newly released clinical study results influencing neurointerventional practice; Information on emerging technologies in this rapidly advancing field. The Handbook is a vital resource for all clinicians involved in neurointerventional practice, including radiologists, neurosurgeons, neurologists, cardiologists, and vascular surgeons.

Excel in your neurology clerkship and on the USMLE Step 2 CK Sixty high-yield cases! You need exposure to cases to pass the USMLE and shelf exams and that's exactly what this innovative resource offers. Written by experienced educators, "Case Files: Neurology, 2e" helps you think through diagnosis and management when confronting neurological clinical problems. Sixty high-yield clinical cases focus on the core competencies for the neurology clerkship. Each case includes an extended discussion, definitions of key terms, clinical pearls, and USMLE-format review questions. It's an interactive learning system that helps you learn instead of just memorize. Featuring: 60 neurology cases with complete discussions and review Q&A Clinical pearls highlight key points; primer on how to approach the patient; helps you learn in the context of real patients; and updated to reflect the most recent clerkship guidelines and changes to the core curriculum.

"Neuroradiology: Key Differential Diagnoses and Clinical Questions" equips you to make efficient, accurate diagnoses and prepare for imaging exams with hundreds of high-quality, unknown cases in neuroradiology. Drs. Juan Small and Pamela Schaefer draw upon Massachusetts General Hospital's vast case collection to help you master the skills you need for interpreting imaging of the head, neck, brain, and spine.

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Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex up to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness and damping are all factors influencing features of tremor. This book discusses the pathophysiology of tremor including membrane mechanisms and rodent models, the advances in genetics and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment, and provides practical informations for the daily management. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced. Future challenges are also presented.

Progressive multiple sclerosis places huge burdens on individuals, carers and society and treatment options are currently limited. However, there have been significant recent advances in understanding progressive disease and this book draws together the field into a single accessible, clinically focused text. Progressive Multiple Sclerosis sets out the basic science, pathology, epidemiology and treatment possibilities in progressive multiple sclerosis. The biological processes underlying disease progression are elucidated and specific pathophysiological mechanisms. The basic science of axonal degeneration and clinical understanding of progressive multiple sclerosis is discussed in the context of emerging and future therapies for disease progression as well as discussion of how trials might be conducted for progressive multiple sclerosis and an overview of biomarkers for the disease. Existing symptomatic therapies for progressive multiple sclerosis are discussed in detail.

Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.